... portion of the moleculeinvolving a-helix A, the nearby loop, the first and lastturns of helices E and F, and the C-terminus helices I and J. In addition, there is a lysine-rich N- and C-ter-minus, ... activation of nuclear transcriptionfactor-jB and the induction of pro -in ammatory pro-duction of cytokines, mainly interleukin (IL)-8 [12]. The activation of a pro -in ammatory signallingcascade ... presence of Cu(II), the protein shows the presence of the ion coordinated in a small cavity of the surface at the polar opposites of each monomer, close to another dimer present in the crystal packing...