... and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivitySushma J Bhakta†, Liang Shang†, Jessica L Prince, Daniel T Claiborne and ... createmutant E. Introduction of the Y7 12C mutation to WT and the Env mutants A, B, C, D, and E resulted in the generation of the Y, YA, YB, YC, YD, and YE mutants. The role of individual motifs ... the plasma membrane occurred in the absence of all of the conserved Y and LL motifs in the CD, ar guing against a critical role for them in outward transport of the pro-tein. Plasma membrane location...