fc gamma receptor mediated modulation of osteoclastogenesis

Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidiﬁcation and cathepsin D in cholera toxin cytotoxicity pdf

... H + - ATPase inhibitor baﬁlomycin and the cathepsin D inhibitor pepstatin A partially inhibited, both in vivo and in vitro, the cAMP response to cholera toxin. This cathepsin D- dependent action of cholera ... action of cholera toxin in rat liver parenchyma. Following administration of a saturating dose of cholera toxin to rats, rapid endocytosis of bot...

Ngày tải lên : 19/02/2014, 02:20

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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc

... activation of the EGFR, where the C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe of the apposed monomer [19,47,84]. Of relevance ... that could account for the Ca 2+ ⁄ calmodulin-mediated regulation of epidermal growth factor receptor activity. The control exerted by calm...

Ngày tải lên : 06/03/2014, 09:22

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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx

... described 1 1 013 10 13 11 22 11 22 13 05 13 05 13 98 13 98 14 62 10 13 10 13 11 22 11 22 13 05 13 05 13 98 13 98 14 62 14 62 1 1305 13 05 13 98 14 62 14 62 11 22 10 13 11 22 11 22 13 05 13 05 13 98 13 98 14 62 14 62 11 22 11 22 13 05 13 98 41 6 2 41 6 2 11 22 11 22 13 05 13 05 13 98 16 2 4 1 6 24 10 13 10 13 11 22 11 22 13 05 13 05 1...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc

... mechanism of this coexpression of counteracting proteins, we investigated the role of the glutathione redox state in vitro because the oxi- dation state of thiols is involved in the metal binding in ... in modulating the metal release from metallothionein in the absence of nitric oxide by Vallee, Maret and coworkers [22,37,38]. These aut...

Ngày tải lên : 07/03/2014, 15:20

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Báo cáo khoa học: Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues docx

... ª 2008 The Authors Journal compilation ª 2008 FEBS Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues Jan T. Andersen 1 , ... the BIAevalution Wizard. The heterogeneous ligand- binding model assumes that two parallel and independent interactions (K D1 and K D2 ) take place betwee...

Ngày tải lên : 16/03/2014, 06:20

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Báo cáo khoa học: Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand pptx

... compilation ê 2007 FEBS 3329 Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand Susanna Boronat 1 , Susana Casado 2 , Jose ´ M. Navas 2 and Benjamin ... Casado S, Alonso M, Herrado ´ n B, Tarazona J & Navas J (2006) Activation of the aryl hydrocarbon receptor by carbaryl: computacional evidence of the ability o...

Ngày tải lên : 16/03/2014, 10:20

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Báo cáo Y học: Transglutaminase-mediated polyamination of vasoactive intestinal peptide (VIP) Gln16 residue modulates VIP/PACAP receptor activity pdf

... Properties of the pituitary adenylate cyclase-activating polypeptide I and II receptors, vasoactive intestinal peptide1 , and chimeric amino-terminal pituitary adenylate cyclase-activating polypeptide /vasoactive ... (Eur. J. Biochem. 269) Ó FEBS 2002 Transglutaminase-mediated polyamination of vasoactive intestinal peptide (VIP) Gln16 residue modulates VIP/PA...

Ngày tải lên : 18/03/2014, 01:20

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Báo cáo khoa học: Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2a receptor mediated activation of MEK⁄ ERK-CREB cascade doc

... mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F 2a receptor mediated activation of MEK ⁄ ERK-CREB cascade Toshiyuki ... mechanism operating in the early phase of adipogenesis through a positive feedback loop by enhancement...

Ngày tải lên : 28/03/2014, 22:20

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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot

... to the ﬁne-tuning of P2XR-mediated signalling by controlling the local kinetics of extracellular agonist degradation and the integration with different purinergic signal inputs (via other purinoceptors ... to speciﬁc signalling pathways. Given that both P2X and other purinergic receptors (i.e. P1 and P2Y) can localize differentially in microdomains of the pl...

Ngày tải lên : 30/03/2014, 02:20

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Báo cáo khoa học: Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane potx

... of the anesthetics benzyl alcohol, propofol, chlo- roform and diethyl ether reversed the resistance by acceleration of the passive transport of the drug or dye across the plasma membrane. At these ... the amount of drug incorporated in the plasma membranes [31], it seems that the anesthetics accelerate the permeation by enhancing the drug...

Ngày tải lên : 30/03/2014, 04:20

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Báo cáo y học: "Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen specie" pptx

... purposes) Vol 9 No 2 Research article Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species Anna-Marie Fairhurst 1 , Paul ... Efficacy of biotinylation was assessed with the 4- hydroxyazobenzene-2-carboxylic acid (HABA) assay. To ensure that the affinity of the antibodies for the...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: "Modulation of LPS stimulated NF-kappaB mediated Nitric" pptx

... induction of NOS2 activity upon activation of PKC by LPS stimulation has also been demonstrated previously using a non-selec- tive inhibitor of all PKC isoforms [16]. However, the role of specific ... representation of the conclusions from all experiments (? = areas of uncertainty). Effect of JAK2 inhibitor on LPS- stimulated NO production in RAW 264.7 cellsFigure 6 Effect...

Ngày tải lên : 11/08/2014, 08:21

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Báo cáo y học: "The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERα-signalling pathway" ppt

... phosphorus containing protein, and two lipid containing proteins, lipovitellins I and II [5-7]. These become the primary substances stored as yolk. In the female fish, the induction of VTG synthesis ... hepatocytes, showed that the potency of the different classes of the AHR-ligands to inhibit the VTG synthesis was directly related to their capability to induc...

Ngày tải lên : 13/08/2014, 13:20

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Báo cáo sinh học: "∆RR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis" docx

... contributes to the neuroprotective activity of the CM from ∆ RR-infected EOC2 and E0C20 cells To examine the effect of IL-10 on the neuroprotective capacity of the CM from ∆RR-infected EOC2 and EOC20 cells, ... lossFigure 9 ∆RR vaccination protects from KA-induced seizures and neuronal loss. (A) Sprague Dawley rats were given 3 intra- nasal doses of R...

Ngày tải lên : 14/08/2014, 19:22

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fc gamma receptor mediated modulation of osteoclastogenesis

... dendritic cells. One class of receptors present on the surface of these cells, which are capable of dictating a cells function, are Fc receptors and modulation of Fc receptors has been shown ... Fc receptor interactions inhibit osteoclastogenesis 69 3.1 Introduction 69 3.2 Results 71 3.2.1 Optimisation of in vitro osteoclastogenesis 71 3.2.2 Fc receptor mediated...

Ngày tải lên : 22/12/2014, 20:59

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