... 2007 FEBS 1233 The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F 5Flavia C. G. Reis1, Tatiana ... prodo-main of cruzipain, the similarity of the mature domain of cathepsin F to that of cruzipain is higher (48 %) than that between the mature domains of cruzipain and cathepsin W (32 %). In order ... inhibitor of cathepsin F To evaluate the selectivity of PCZ as an inhibitor of papain-like enzymes, the propeptide was incubated for30 min with papain or human cathepsins B, L, S, K, V and F...