... 4589MINIREVIEWPoly(ADP-ribose) The most elaborate metabolite of NAD+Alexander Bu¨rkleDepartment of Biology, University of Konstanz, GermanyIntroduction The life cycle of poly(ADP-ribose)NAD+⁄ NADH is among the most ... developed over the last couple of years are (a) the localized relaxation of chromatin at the site of DNA damage, mediated either by direct modifi-cation of histones or noncovalent interaction of histoneswith ... within the known members of the PARP family. Adjacent to the ANK domain isanother protein interaction motif, the sterile alpha-module. The C-terminus of tankyrase displays homo-logy to the PARP-1...