THE INFLUENCE OF THE KU80 CARBOXY-TERMINUS ON ACTIVATION OF THE DNA-DEPENDENT PROTEIN KINASE AND DNA REPAIR IS DEPENDENT ON THE STRUCTURE OF DNA COFACTORS Derek S
Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf
... this is the first report in which glycosylation of a TGF-b superfamily ligand is essential for the versatility in receptor binding. Results and Discussion Structure of human BMP-6 Structures of ... building using quanta2006 software (Accelrys Inc., Table 3. Processing and refinement statistics. Statistical analyses for the highest-resolution shell are shown in parentheses....
Ngày tải lên: 23/03/2014, 07:20
Báo cáo sinh học: " Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein" pot
... levels of all other viral proteins. This suggests a role for VP30 in replication or transcription. The self-interaction of NP is the basis for the formation of the helical nucleocapsid of MARV. ... function of NP in RNA synthesis. Discussion Coiled coil motifs are versatile domains that mediate the interaction of proteins [16]. The central feature of coiled coil mo...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo hóa học: " Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein" pdf
... function of NP in RNA synthesis. Discussion Coiled coil motifs are versatile domains that mediate the interaction of proteins [16]. The central feature of coiled coil motifs is the presence of repeats ... intra- and intermolecular binding, is a prerequisite for NP to perform its multiple tasks in RNA synthesis and nucleocapsid morphogenesis. This concept is supported b...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo y học: " The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose" ppt
... response was confined to the tissues is of interest as the aim of these models is to mimic the human asthmatic condition, in which a significant portion of reactivity of the lungs is localised ... Further investigation is needed in order to understand the mech- anisms that are influencing the site of responsiveness. Typically, most human studies measure MCh respo...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo sinh học: "Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery" docx
... as multinucleated cells. It is pos- sible that these tissue characteristics are responsible for the prolonged presence of the message to Hsp65 in the muscle tissue. However, there is no satisfactory ... suggesting the absence of inflammatory response in these tissues (manuscript in preparation, Deison Soares personal communication). To assure that the plasmid rescued from di...
Ngày tải lên: 14/08/2014, 19:22
Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... of the peptide. The origin of this structural orientation in Me 2 SO is also the strong electrostatic interactions of the side c hain of Arg78 with the side chains of Asp81 and G lu82 [this is consistent ... Me 2 SO, are possibly due to electrostatic interactions promoted in this solvent ( see discussion below). A comparison of the chemical-shift data of the...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities pdf
... puta- tive Pro-Glu-Ser-Thr site of proteolysis and several putative phosphoryla- tion sites. In this study, we analysed CNBP phosphorylation by embryonic kinases and its consequences on CNBP biochemical ... phosphorylated on Ser ⁄ Thr residues In silico analysis showed that CNBP amino acid sequences possess putative phosphorylation sites mainly on Ser ⁄ Thr residues (Fig. 1). To c...
Ngày tải lên: 16/03/2014, 12:20
Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling ppt
... France). Statistical analysis Using the nonparametric Kolmogorov–Smirnov test and the Levene test, it was established that the distribution of data obtained with different clones was normal. Student s t-test ... he QuickChange Site-directed Mutagenesis Kit (Stratagene) was used to switch serines 73 and 138 and threonine 153 of the HIP/PAP protein for alanines. Oligonucleo...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... expression of HSP90 in the two rat tissues are similar to those present in these cell models [27], we propose that the occurrence of conditions which favour the formation and stabilization of proteolytically ... 4B,D). The involve- ment of calpain in these digestion processes was dem- onstrated by the protective effect on both HSP90 and NOS degradation of the admin...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo y học: " The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion" potx
... citation purposes) compensated for by one or more of the acquired substitu- tions. We also did not observe restoration of the disulfide bond by means of a first site reversion at position 418. This ... and the CXCR4 coreceptor for HIV-1 LAI in relation to the positions of the mutations and reversions in our viruses is given in fig. 4A. Soluble CD4 (sCD4) was used to a...
Ngày tải lên: 13/08/2014, 06:20