Báo cáo y học: " Ultrafast and memory-efficient alignment of short DNA sequences to the human genome" pdf
Báo cáo y học: " Ultrafast and memory-efficient alignment of short DNA sequences to the human genome" pdf
... Genome Biology 2009, 10:R25Open Access2009Langmeadet al.Volume 10, Issue 3, Article R25Software Ultrafast and memory-efficient alignment of short DNA sequences to the human genomeBen ... properly cited.Bowtie: short- read alignment& lt;p>Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes.</p>AbstractBowtie is an ultrafast, ... exactoccurrences of the query in the text. If the range is empty, the text does not contain the query. UNPERMUTE is attributable to Burrows and Wheeler [17] and EXACTMATCH to Ferra-gina and Manzini...
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Báo cáo y học: "Clinical and serological evaluation of a novel CENP-A peptide based ELISA" pdf
... of human CENP-A was used as the template for the commercial synthesis of syntheticpeptides (Peptides & Elephants, Berlin, Germany). The quality and purity of the peptide were assessed by ... of SSc patients. Therefore, no infor-mation was obtained for the clinical sensitivity of the peptide based assays. Another limitation of the study was the lack of disease controls to prove the ... shown that some of the identified mimo-topes cross-react with each other [28]. The observationthat these mimotopes are cryptic epitopes may explain inpart the obvious challenge of why CENP-A aabs...
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Báo cáo y học: "Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats" pot
... antiinflammatory properties [36] and, therefore,ED7+ AM seem to play a role in the control of the inflam-matory reaction. On the other hand these ED7+ AM alsoproduce higher amounts of IL-12, a cytokine ... clearly suggest that the newly recruited ED7+ AMare involved in the regulation of the ongoing inflamma-tory process. Whether the antiinflammatory effects of IL-10 or the proinflammatory role of ... macrophages[4,8]. On the one hand they are characterized by a highercapacity to phagocytose foreign material, increased pro-duction of reactive oxygen and nitrogen species and of the pleiotropic cytokine...
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Báo cáo y học: "Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins" doc
... IFIFLYLYP Y E L Y G LDPDPRPLPLD K F F LYLYP Y E L Y G LDPDPRPLPLD F IFIFLYLYP L Y G LDPDPRPLPLD K F IFIFLYLYP Y E L Y G LDPDPRPLPLD K F IFIFLYLYP Y E L Y G ... LFYNVTYT A YRLS FGF EYSNL TEIG KKLT RF RY G TDRT GYFTN STRFLLHKQWT L YSLT YKF SYSN- KEYSR L NA FIVAE KQ K LAVE VLLHKQWT I YSLT YKF SYSN- KDYSR L SA FIVAE KQ K VAVE VLLSKQWT L YSVT MH KF SYTN- ... Symptomatic of the simplicity of the E. cuniculikinetochore is the absence of the vast majority of potentialMAPs. Nonetheless, it is significant that the E. cuniculi kine-tochore contains three of the...
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Báo cáo y học: "Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gond" pptx
... signals in the genome and to uncoverunderlying gene-regulatory mechanisms. Sequence analysis to identify conserved cis-regulatory signals is typically aug-mented by at least one of two types of information: ... motifs within the upstream and the coding regions of the genome, respectively,as computed by MAST (Motif Analysis and Search Tool) [15].In order to normalize for the different sizes of the two datasets, ... regulatory questions in the actively multiply-ing tachyzoite, as any given population of cells in culture con-sists of parasites at different points of their cell cycle.Our study reports the...
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Báo cáo y học: " Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome" pptx
... <0.01)measured by: (1) the physical distance (in kilobases)from the SNP to the center of the hotspo t; and (2) the number of SNPs between the candidate SNP and the proximal boundary (also a SNP) of the ... inAdditional file 3), the vast majority of random P-valuesare uniformly distributed, indicating that they correspond to the truly null hypothesis. Compared with the real case, the set of artificial ... (that is, the region between two consecutiveSNPs), and the recombination activity of a segment ismeasured by the product of r and physical length of the segment. The recombination activity of a...
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Báo cáo y học: "cis-Decoder discovers constellations of conserved DNA sequences shared among tissue-specific enhancers" pptx
... transcription factors and their targetDNAs. The enhancer or cis-regulatory module is the focalpoint of integration for many of these regulatory events.Enhancers, which usually span 0.5 to 1.0 kb, ... informationGenome Biology 2007, 8:R75into the function of these 'evolutionarily hardened' sequences and ultimately produce a better understanding of the regula-tory code underlying coordinate ... upperwindow of cDT-scanner and then pasting the EvoPrint orCSBs to which they are to be aligned in the lower window. The output of cDT-scanner consists of perfect matches of cDTsaligned under the input...
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Báo cáo y học: " Facilitators and obstacles in pre-hospital medical response to earthquakes: a qualitative study"
... of the manuscript. MC contributed to analyze and interpret the data and to write the manuscript. LK participated to the study design, analysis and results interpretation and writing-up of the manuscript. ... and because of the inability to admit the casualties, they were referred to yet a second city“ according to another interviewee. The lack of a coordinated plan for transportation of the casualties ... in the conception and design of study and took an active part in the data analysis and results interpretation. GO participated to the study conception and design, writing-up and finalization of...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... substantial contributions to conception and design, and to the analysis and interpretation of the data. TRM and GWC handled acquisition of data. All authors contributed to the manuscript revision ... on the prevalence in the population, and more reflective of the test itself, lessening the impact of any unique features of the VA population. Moreover, we might expect that the PPV and NPV of ... frequency - 2 Data shown are n of treatment episodes in the off-diagonal cells of Table 4. Column totals may sum to > 100% since there may be multiple reasons why patients did not meet the...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... only to the extent that they are limited to the peribronchial and perivascular spaces. There is recruitment of T and B lymphocytes as well as dendritic cells, but there does not appear to ... found to be suffi-cient to drive autoimmune diabetes [26]. Most of the inflammatory responses described above arguably fall into the category of Th1-mediated effector mecha-nisms. Moreover, they ... accumulation of lymphocytic infiltrates and long term induction of tissue remodel-ing. Therefore, we wanted to determine whether there were elements of the lung allergic inflammatory response...
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