Báo cáo y học: " Ultrafast and memory-efficient alignment of short DNA sequences to the human genome" pdf

... Genome Biology 2009, 10:R25 Open Access 2009Langmeadet al.Volume 10, Issue 3, Article R25 Software Ultrafast and memory-efficient alignment of short DNA sequences to the human genome Ben ... properly cited. Bowtie: short- read alignment& lt;p>Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes....

Ngày tải lên: 14/08/2014, 21:20

... of human CENP-A was used as the template for the commercial synthesis of synthetic peptides (Peptides & Elephants, Berlin, Germany). The quality and purity of the peptide were assessed by ... of SSc patients. Therefore, no infor- mation was obtained for the clinical sensitivity of the peptide based assays. Another limitation of the study was the lack of d...

Ngày tải lên: 12/08/2014, 14:21

... antiinflammatory properties [36] and, therefore, ED7 + AM seem to play a role in the control of the inflam- matory reaction. On the other hand these ED7 + AM also produce higher amounts of IL-12, a cytokine ... clearly suggest that the newly recruited ED7 + AM are involved in the regulation of the ongoing inflamma- tory process. Whether the antiinflammatory effects...

Ngày tải lên: 12/08/2014, 16:20

... IF IF LY LY P Y E L Y G L DP DP RPL PL D K F F LY LY P Y E L Y G L DP DP RPL PL D F IF IF LY LY P L Y G L DP DP RPL PL D K F IF IF LY LY P Y E L Y G L DP DP RPL PL D K F IF IF LY LY P Y E L Y G ... L FYNVTYT A YRLS FGF EYSNL TEIG KKLT RF RY G TDRT GYFTN STRF LLHKQWT L YSLT YKF SYSN- KEYSR L NA FIVAE KQ K LAVE V LLHKQWT I YSLT YKF SYSN- KDYSR L SA FIVAE KQ K VAVE V LLSKQWT L...

Ngày tải lên: 14/08/2014, 16:21

... signals in the genome and to uncover underlying gene-regulatory mechanisms. Sequence analysis to identify conserved cis-regulatory signals is typically aug- mented by at least one of two types of information: ... motifs within the upstream and the coding regions of the genome, respectively, as computed by MAST (Motif Analysis and Search Tool) [15]. In order to normal...

Ngày tải lên: 14/08/2014, 21:20

... <0.01) measured by: (1) the physical distance (in kilobases) from the SNP to the center of the hotspo t; and (2) the number of SNPs between the candidate SNP and the proximal boundary (also a SNP) of the ... in Additional file 3), the vast majority of random P-values are uniformly distributed, indicating that they correspond to the truly null hypothesis....

Ngày tải lên: 09/08/2014, 22:23

... transcription factors and their target DNAs. The enhancer or cis-regulatory module is the focal point of integration for many of these regulatory events. Enhancers, which usually span 0.5 to 1.0 kb, ... information Genome Biology 2007, 8:R75 into the function of these 'evolutionarily hardened' sequences and ultimately produce a better understanding of the reg...

Ngày tải lên: 14/08/2014, 07:21

... of the manuscript. MC contributed to analyze and interpret the data and to write the manuscript. LK participated to the study design, analysis and results interpretation and writing-up of the manuscript. ... and because of the inability to admit the casualties, they were referred to yet a second city“ according to another interviewee. The lack of...

Ngày tải lên: 25/10/2012, 09:56

... substantial contributions to conception and design, and to the analysis and interpretation of the data. TRM and GWC handled acquisition of data. All authors contributed to the manuscript revision ... on the prevalence in the population, and more reflective of the test itself, lessening the impact of any unique features of the VA population. Moreover...

Ngày tải lên: 25/10/2012, 10:45

... only to the extent that they are limited to the peribronchial and perivascular spaces. There is recruitment of T and B lymphocytes as well as dendritic cells, but there does not appear to ... found to be suffi- cient to drive autoimmune diabetes [26]. Most of the inflammatory responses described above arguably fall into the category of Th1-mediated effector me...

Ngày tải lên: 03/11/2012, 11:24