Báo cáo y học: " Gene expression regulation in the context of mouse interspecific mosaic genomes" pdf

... scrutiny, or their hybrids. Clearly, expression in hybrids is made very complex, for instance, by the generation of a large quantity of abnormal heteromeric proteins [13]. Therefore, analyzing expression ... to the interval defined by the two lines. The expression of these genes was presumably driven to a SEG expression level by their cis-elements of SEG origin. On...

Ngày tải lên: 14/08/2014, 20:22

... sus- ceptibility and to the inflammatory processes that mediate the pathology of this model. Conclusion The present study identified the temporal gene expression profiles of hundreds of genes, including cytokines, ... of the joint cell composition in this model [6,21]. Gene expression profiling of arthritic rat joints revealed a spectrum of genes exhibiting ext...

Ngày tải lên: 09/08/2014, 06:22

... compared with the two other groups. GO pathway analyses indicated that these genes were characterized by a distinct signature made of genes involved in the regulation of the cell cycle (28% of the GO ... be representative of the globality of the slide. The surface staining (S) and the surface of the nuclei (N) were determined for each image, and the area o...

Ngày tải lên: 09/08/2014, 14:20

... arthritis (RA), the gene expression profile is extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune disease [1- 5]. The overall ... predicting the prognosis of the dis- ease. The major obstacles in the human studies are the relatively late diagnosis of RA, the large variety of c...

Ngày tải lên: 09/08/2014, 06:22

... death may involve BCL-2 family genes in the intrin- sicmitochondrialpathwayaswellastheTNFS F10 gene in the death receptor signaling pathway (Figure 2) [20]. Upregulation of the TNFSF10 gene activated ... downregulated by 3-4 fold. The expres- sion levels of SPP1andCREBBP genes involved in the transforming growth factor (TGF-b) pathway were down by 16 fold. The change...

Ngày tải lên: 10/08/2014, 21:23

... in systemic sclerosis are only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression in patients ... exclude cells not of interest for the analysis. Indeed, the interest of the me thod reported here lies in the high intra-assay reproducibility and the high...

Ngày tải lên: 12/08/2014, 14:22

... description of variable phenotypic outcomes in DS. Mapping the regulators of Hsa21 genes in man and in mouse is essential to elucidating the genetic basis of the variation of gene expression and ... expression, and the variation in basal gene expression levels in the population. An understanding of the pathogenesis that produces features of DS will...

Ngày tải lên: 14/08/2014, 07:21

... neighbor-joining trees of the 16 strains created using DNA polymorphism data and the gene expression distance matrixComparison of the neighbor-joining trees of the 16 strains created using DNA polymorphism ... within each hybridization (that is, rand- omizing within a column), thereby maintaining the underly- ing data structure (for example, missing data) within each hybri...

Ngày tải lên: 14/08/2014, 08:20

... differ- ing in the extent and/or severity of the injury and/or the co- occurrence of other noted histopathological observations, such as the type of inflammatory cell infiltrates, the presence of ... any injury at any of the time points. However, the galactosamine and thioaceta- mide samples grouped together. Interestingly, these are the only two compounds that evo...

Ngày tải lên: 14/08/2014, 20:22

... mechanism involved in the regulation of HLA-DR, as described in the study of Fumeaux et al. (2002), flow cytometry and immunoflourescence were used to determine intracellular HLA-DR expression in ... up-regulated. These results indicate that the mechanisms involved in the regulation of HLA-DR in sepsis include shedding of HLA-DR from the cell surface and...

Ngày tải lên: 03/11/2012, 09:57