Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx

... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin ... asymmetric division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant Numb is critical in determining lineage commit...

Ngày tải lên: 14/08/2014, 20:22

... many of the specialists, mainly from Europe and the USA, working on cancer and signal transduction. It was the 20th meeting in this series, and celebrated 50 years since the discovery of protein ... described the families of human kinases and the domains that they contain. Interestingly, 40% of all kinases have multiple splice variants and 10% of the total encode...

Ngày tải lên: 09/08/2014, 20:20

... least- square linear fitting within a window sliding through the data. The size of the window (span) controls the degree of smooth- ing and the curves are made robust by iterating the fit within each window ... suggesting, given the partially independent origin of MIR sequences in eutheria and metatheria, the evolutionary conservation of a specific function for MIRs loca...

Ngày tải lên: 14/08/2014, 17:22

... engage and stimu- late monocytic cells, resulting in the synthesis of TNF. This finding opens the possibility of exploring new therapeutic tar- gets for RA and probably other chronic inflammatory ... supporting the importance of intercellular contacts in the pathogenic mechanisms underlying RA. Indeed, the importance of these cell-cell interactions in the synthesis and...

Ngày tải lên: 09/08/2014, 08:22

... of illness/injury they will suffer and what types of medical interventions they must consider [5]. Because medicine is not static, making a prospective determination regarding the types of treatment ... the issue. We ought not to be overly concerned with the execution and application of advanced directives but with the motivation behind them and the dialogue they engender over...

Ngày tải lên: 13/08/2014, 08:20

... transported into the blood by the vitamin D-binding protein (VDBP) is converted in the liver by 25-hydroxylases (CYP34A, CYP27A1, CYP2R1, ) into 25-hydroxyvitamin D (25- (OH)D). 25-(OH)D is considered the ... regulatory T-cells (Treg) which inhibit the activation of Th1 lymphocytes by antigen-presenting cells (APC) [36], (b) by directly inhibiting activation of Th1 lymphocytes...

Ngày tải lên: 10/08/2014, 05:21

... [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, produce a variety of cytokines, chemok- ines ... expression and by stimulating the synthesis of MMP-1 and IL-1 [50]. We hypothesize that the relatively stable expression and tight regulation control of synovial glycosidases...

Ngày tải lên: 09/08/2014, 14:20

... expertise. In addition, MU was involved in the cytochrome assays and led and guided the metabolite measurements. TD led and guided the study, supervised AC, and was involved in the data analysis of ... added. In vitro inhibitory activity of IQ-143 on CYP enzymes To test the inhibito ry activity of IQ-143 on the six main human drug-metabo lizing CYP enzymes, we appl...

Ngày tải lên: 09/08/2014, 22:24

... for early detection of inflammatory and infective lung dis- eases in childhood are of high interest. Lipopolysaccharide ( LPS) is recognized by the human immune system via binding to LPS binding ... severity, as defined by the activity and physical examination criteria of the scoring system of Shwachman and Kulczycki [13]. A ll CF pati ents were clinically stable at least 2 mo...

Ngày tải lên: 12/08/2014, 11:21

... design of the study. MAL-N and JLV carried out the HLA determination, analyzed and interpreted the data, and helped in the manuscript preparation. All authors read and approved the final manuscript. Acknowledgements We ... may be present in other diseases and in healthy older individuals [5]. In contrast, anti-citrulli- nated protein antibodies (ACPAs) seem to play...

Ngày tải lên: 12/08/2014, 12:20