Báo cáo y học: " Identification of transcripts with enriched expression in the developing and adult'''''''' pptx

... libraries, multiplied by the log of its count in the library of interest, by the number of libraries the tag was found in. Tags were then ranked on their maximum specificity in any one of the pancreas ... calculated the specificities (S values) of each of these tags to each of the 205 libraries by dividing the ratio of the tag count in the library o...

Ngày tải lên: 14/08/2014, 20:22

... by sensitivity analyses. Competing interests The studies included in this analysis were sponsored by Eli Lilly and Company, the manufacturer of olanzapine. VS, HAS, LL, and RC are all employees ... understanding of efficacy in the treatment of schizophrenia. The source studies for these analyses were double-blind, randomized trials of signifi- cant duration, and incl...

Ngày tải lên: 11/08/2014, 16:23

... (including Syncytin-1 and -2) have unambiguous EST matches. By far, Syncytin-1, dominates with 100 EST matches, fol- lowed by Syncytin-2 and HERV-R. Syncytin-1 and Syncy- tin-2 were predominantly found in ... like the syncytin genes [26- 28] and iii) a hypothesized role in preventing the immune response against the developing embryo by means of the immunosuppressive...

Ngày tải lên: 13/08/2014, 13:20

... than in euchromatin and they contain longer introns. These differences are likely due to an abundance of TEs and repetitive DNA not only in intergenic regions, but also in the introns of genes in ... organizational structure of these chromosomes, or they may merely reflect the still-incomplete state of the assembly and map of the genome sequence. A very high de...

Ngày tải lên: 14/08/2014, 08:21

... isobutyl-methylxanthine and indomethacin. About 10–30% of the OC cells were reproducibly induced toward the adipogenic lineage as early as 2 weeks after induction (Fig. 5g,5h). Using PCR, the expression of peroxisome ... staining. The distribution of OC cells in forward/side scatter exhib- ited no difference between isotype and antibody staining. A maximum of 2% positi...

Ngày tải lên: 09/08/2014, 01:23

... whereas the b strands lining the inner c oncavity contain s everal charged residues exposed to the solvent. The glycosaminoglycan chain and the N-linked oligosaccharides are on the same side of the molecul ... unable to bind decorin, interrupts the periodicity. On the other side, the relevance of Lys/Hyl residues both in collagens and peptides for interaction wi...

Ngày tải lên: 21/02/2014, 15:20

... is inline with the assumption that plasma and memory B cells accumu- late in the parotid gland but cannot clarify the origin of these cells. Whatever the primary aberration in the induc- tion of ... that inflamed ductal epithelial cells represent the focus of the inflammatory response in the salivary glands of patients with SS. There is clear evi- dence of...

Ngày tải lên: 09/08/2014, 03:24

... details, reviewing the literature and drafting the manuscript. AC was involved in reviewing the literature and proofreading the manuscript. VA approved the final manuscript. Consent Written informed ... have no competing inter- ests. Authors' contributions EP is the senior author and was involved in collecting patient details, reviewing the literature and final...

Ngày tải lên: 11/08/2014, 23:21

... pathway is activated by lymphotoxin β, BAFF, and CD40 ligand, thus playing roles in the development and organogenesis of the lym- phoid system. Moreover, both pathways are aberrantly activated in ... [21]. The canonical NF-κB pathway is typically activated by inflam- matory cytokines such as TNFα and IL-1, thus playing roles in inflammation as well as in apoptosis. In...

Ngày tải lên: 12/08/2014, 23:22

... grey) and the binding wild-type receptor (solid black line). It is clear that the QLH(108–110)KPY mutation completely abolished PERV-A SU binding. The lack of both binding and infection of the ... N-terminal region of HuPAR2 for binding and infectionFigure 4 Single residue and mini-region mapping of the eighteen amino acid differences in the critical N-terminal...

Ngày tải lên: 13/08/2014, 05:21