Báo cáo y học: "Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription" pot

... RefSeq genes and of partially (PIN) and totally (TIN) intronic noncoding transcriptsFigure 1 Length distribution of exons from RefSeq genes and of partially (PIN) and totally (TIN) intronic noncoding ... the contribution of RNAP II to the biosynthesis of intronic ncRNAs in human cells by blocking its activity with α-amanitin and measuring the levels of...

Ngày tải lên: 14/08/2014, 20:22

... genes in our study appeared in one or more of the lists of genes identified as being involved in immunity in the microbial pathogen studies in adults, and only 8-10% of the genes in our study were ... signaling pathway factors Phosphotidylinositol 3-kinase (PI3K) - GTP-binding proteins (Ras/Rho family members) - Protein kinase C (PKCs) or PKC regulators CG5958 (PKC t...

Ngày tải lên: 14/08/2014, 15:20

... cata- lyses the hydrolysis of agmatine to putrescine and urea [1]. Agmatine, which results from decarboxylation of arginine by arginine decarboxylase [2], is a metabolic intermediate in the biosynthesis ... biosynthesis of putrescine and higher polyamines [1] and may have important regulatory roles in mammals [3–5]. Agmatinases from Escherichia coli and human tissues, a...

Ngày tải lên: 21/02/2014, 01:21

... entry only into T cells Evaluation of C14 efficiency to inhibit limit the entry of HIV-1 into primary cellsFigure 4 Evaluation of C14 efficiency to inhibit limit the entry of HIV-1 into primary ... capacity to inhibit the entry of HIV-1 into T cells and may limit the reverse transcription step into macrophages and DC. These findings indicate that C14 harbours potent HIV-1...

Ngày tải lên: 10/08/2014, 05:21

... survival. The indications and dose remain the same as in women [2,6]. Ablative techniques aiming to control hormones, including orchidectomy, adrenalectomy and hypophysectomy, have been used in the ... margin and all other margins were more than 0.8 cm. The patient had four cycles of chemotherapy (Doxoru- bicin 100 mg and Cyclophosphamide 1000 mg) and adjuvant chest wall rad...

Ngày tải lên: 11/08/2014, 23:21

... pro-inflammatory cytokines, chemokines and adhesion molecules [21]. These pro- inflammatory mediators are essential in the recruitment of airway inflammatory cells, including EOS and CD4 + T lymphocytes, ... broader anti-inflammatory activity of As 2 O 3 lies in the inhibition of NF-κB activation through induction of IκBα expression in the airways. Clinically, low dosage...

Ngày tải lên: 12/08/2014, 16:20

... defining regulatory motifs in the cisRED database [http://www.cisred.org/]. MicroRNAs (miRNAs) are a class of RNA genes that can now be detected thanks largely to the availability of a number of ... (SNPs) and proteomics are being generated in high-throughput mode. To make sense of this flood of heterogeneous data and make it useful to scientists, powerful informatic...

Ngày tải lên: 14/08/2014, 14:21

... components of susceptibility to elevated IOP to this population. cAMP signaling in glaucomatous ONH astrocytes Earlier work in our laboratory indicated upregulation of two adenylyl cyclases (ADYC3 and ... receptor signaling to the regulatory machinery of the cytoskeleton [42]. The enigma family member PDLIM1 was upregulated in AAG astrocytes (Table 3) and functions by al...

Ngày tải lên: 14/08/2014, 20:22

... clearly visible in the wild-type enzyme, in the A32 8Y mutant and in the ÔcompensatoryÕ mutant (Y3 32D/D7 0Y) . It can only be perceived in Y3 32A/D70G mutant but is absent in the W82A and in horse enzyme. ... Two amino-acid residues (D70 and Y3 32) in the PAS and two (W82 and A328) in the CS, known to play a role in the binding of positively charged ligand...

Ngày tải lên: 24/03/2014, 03:21

... variable ITRs in the diversification of potentially important genes in human evo- lution, we manually analyzed and reconstructed the structure of the ITR-containing exons in this family. Overall, ... long and variable ITRs are involved in the modification of 7% of human genes hosted in primate-specific SDs. These genes are very recent and therefore likely to...

Ngày tải lên: 09/08/2014, 20:21