Báo cáo sinh học: " Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats" ppt

... Access Research Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats Tracey Graham, Jenny McIntosh 2 , Lorraine M Work 1 , Amit ... intravascular injection, particularly in relation to haemophilia gene therapy. AAV8 has also been proposed for gene therapy targeted at skeletal and c...

Ngày tải lên: 14/08/2014, 19:22

... scale of 0-18 (normal score 0, maximal deficit score 18) Statistical analysis Data were presented as mean values and standard devia- tion. A method of ANOVA (analysis of variance) with Scheffe’s ... Principles of Laboratory Animal Care formulated by the National Society for Medical Research and the Guide for the Care and Use of Laboratory Animals published by the U.S. National Ins...

Ngày tải lên: 18/06/2014, 19:20

... instead of viral RNA (Fig. 8A, compare lane 1 with lane 3). In contrast, the yield of virus from reactions templated by ribozyme-treated transcript RNAs was essentially the same as what was obtained ... filter-binding assay. As shown in Fig. 2A, RNA synthesis is maximal 8 hrs after the start of transla- tion and by 16 hr the total amount of RNA present in the reaction decreases. At...

Ngày tải lên: 19/06/2014, 08:20

... genetics (Falconer, 1981; Larzul et al, 1997). When considering a low initial A allele frequency, the fixation of the A allele was easier for an additive allele than a dominant ... phenomenon was observed in the case of a large major gene, where the mean A allele frequency reached a plateau at 0.91: 9% of the runs showed a loss...

Ngày tải lên: 09/08/2014, 18:22

... Guay, 1979; Hanada and Muramatsu, 1980; Uchida et al, 1986). In humans, on the other hand, an important fragile X site (Fra Xq 27.3) has been related to a particular ... de Citogenética de Animales Domésticos, Area Genética, Departamento de Biolog a Molecular y Celular, Facultad de Veterinaria, Lasplaces 1560, Montevideo, Uruguay (Received 17...

Ngày tải lên: 09/08/2014, 18:22

... observed outcome. To take this aspect of a model's performance into account, we have to look at the calibration and accuracy of the prognostic models. 'Calibration' refers to the agreement ... Glassman J, Nierman DM, Wallace SK, Price K, Horak D, Landsberg D: Probability of mortality of critically ill cancer patients at 72 h of intensive care unit (ICU) manageme...

Ngày tải lên: 12/08/2014, 22:22

... effect a ects a quantitative trait. 430 A. Narita, Y. Sasaki which may have some epistatic effects on one another. To ascertain the com- plicated mechanism of quantitative traits, conventional methods ... overestimated, it is clear that the overall mean, the positions and effects of QTL, and polygenic variance were also accurately estimated. For compar- ison, one of the simulated data...

Ngày tải lên: 14/08/2014, 13:22

... used as control. The total tumor area of each bladder was determined and the mean of the total areas was calculated for each group. The Mean and SD of bladder tumor area (A) and weight (B) are ... sequences Doron Amit * , Abraham Hochberg Abstract Background: The human IGF2-P4 and H19 promoters are highly active in a variety of human cancers (including bladder cancer), while exi...

Ngày tải lên: 18/06/2014, 16:20

... data was of high quality, the hospital emergency data was inadequate to allow analysis with regard to either DSH or mental health presentations. Additionally, records of treatmen t by gen- eral ... sharply with decreasing maternal age in the teenage years, both with maternal age a s an unadjusted variable and also when adjusted for c onfounding by the other variables from the proporti...

Ngày tải lên: 11/08/2014, 16:22

... Access Review Impact of an in-built monitoring system on family planning performance in rural Bangladesh Humayun Kabir*, Rukhsana Gazi, Ali Ashraf and Nirod Chandra Saha Address: Health Systems and Infectious ... Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh Email: Humayun Kabir* - humayun@icddrb.org; Rukhsana Gazi - rukhsana@icddrb...

Ngày tải lên: 18/06/2014, 17:20