Báo cáo y học: "Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution" pdf

... 80- 110 million years ago [35]. The redundancy between these 14 gene pairs has therefore been maintained for more than 80 million years of evolution. We believe that it is extremely unlikely that ... common ancestor 80- 110 million years ago [35]. It is extremely unlikely that the redundancy between these 14 genes has been maintained for more t...

Ngày tải lên: 14/08/2014, 17:22

... clusters maintained only by chance (genes not yet separated by recombination) disappear, on average, more rapidly in the course of evolution than those maintained by selection pressure. In that case, clusters ... oligonucleotide/oligosaccharide-binding (OB)-fold containing protein, a recently described new GTPase, DnaG) are encoded by genes that co-localize with DNA replicat...

Ngày tải lên: 14/08/2014, 08:21

... responsible for dietary-restriction-induced longevity in C. elegans. e most likely pathway exploited by dietary restriction in C. elegans is the TOR pathway. e physiological role of TOR kinase ... with phenylalanine and tyrosine. A similar increase in branched-chain amino acids has been found in animals carrying mutations in components of Abstract The nematode Caeno...

Ngày tải lên: 06/08/2014, 19:21

... have overlapping function during morphogenesis (Table 2), indicating that the functional relationship between this pair of genes has been selectively maintained for over 100 million years. This ... means of synthetic genetic analysisDouble RNAi by soaking worms in dsRNA for two genes at once is an inefficient means of synthetic genetic analysis. Percent embry-onic lethali...

Ngày tải lên: 14/08/2014, 14:21

... the four isoforms, with exons zoomed in. The tail of exon 1 of the first isoform is 6 bp less than that of the other three isoforms. The second isoform has 7 exons, while the third isoform misses ... Statistical inferences for isoform expression in RNA- Seq. Bioinformatics 2009, 25:1026-1032. 14. Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ: Deep surveying of alternative s...

Ngày tải lên: 09/08/2014, 20:22

... shows decay rates determined for all expressed ncRNAs and asRNAs during the time course (excluding tRNAs and rRNAs). Interestingly, many of these RNAs displayed short decay rates of less than a minute ... fitting method for determining RNA decay rates, we found a median half-life of 2.4 minutes and a median decay rate of 2.6 minutes for expressed genes - twofold faster th...

Ngày tải lên: 09/08/2014, 20:22

... replication kinetics in CEMx174 lines or in rhesus PBMC. Yet, the pU∆14 mutant was found to reduce vRNA packaging by approximately 40% perhaps indicating that the secondary structure of this element may be ... demonstrated that HIV-2, employs a co-translational mechanism of RNA packaging whereby newly translated Gag polyprotein interacts with vRNA while in a ribosomal transl...

Ngày tải lên: 13/08/2014, 09:20

... came in large numbers in response to the Pakistan earthquake [28]. In spite of the long delay, the role of international volunteer teams is important in helping the affected community. International ... military air force within a few hours of locating the earthquake. Some of them were medical doctors, including surgeons and emergency medicine physicians. The airport was full...

Ngày tải lên: 25/10/2012, 09:56

... week to 78 years old. Nearly one third of all insertions (n = 22) were made in patients younger than two years. Intraosseous use by age is presented in Table 1. Presenting diagnosis Intraosseous ... number of patients treated IO insertion rate % 0-2 years 18 453 3.97% 3-6 years 0 198 0.00% 7-17 years 5 486 1.03% 18-78 years 47 4979 0.94% IO - Intraosseous. Sunde et al. Sc...

Ngày tải lên: 25/10/2012, 10:02

... [http://www.who.int/healthsystems/ EN_HSSkeycomponents .pdf] . 16. Ministry of Health: Proceedings of the conference on reform of Iraq national health system: Baghdad Baghdad: Ministry of Health; 2008. 17. Albert ... health system. Even though the role of private sector in delivering health services in Iraqi Kurdistan is increasingly growing, it was not included in this study....

Ngày tải lên: 25/10/2012, 10:06