Báo cáo y học: "ining the HapMap to dissect complex traits" docx

... regula- tory variation”, which simply maps to the affected gene. This local regulatory variation may be due either to cis vari- ation or to variation in components acting in trans in an autoregulatory ... mapping. Single-feature polymorphisms (SFP) can help to achieve this. These are polymorphisms that are defined by the use of high-density oligonucleotide tiling arrays for genoty...

Ngày tải lên: 14/08/2014, 16:21

... the slope of a pressure–volume curve reflects the compliance (or elastance) of the respiratory system, regard- less of the position of the curve [11]. That is, we have Commentary Is the way to ... differ. IAH may become an even greater issue in the medical intensive care unit with the obesity pandemic, since body mass index is the best independent predictor of IAP [2]. Fur...

Ngày tải lên: 13/08/2014, 19:20

... associated with a shorter ICU stay by 9.7 days and hospital stay by 24 days than the control group. Agitated delirium was more frequent in the intervention group than the control group (20% vs. ... proof of concept study. Larger, multicenter trials are necessary to determine the feasibility and safety of this approach. Competing interests The authors declare that they have no...

Ngày tải lên: 14/08/2014, 07:21

... study protocol, the results showed that polyurethane, followed by polypropylene and poly- amide, seems to be the first choice to suture a swollen surgical wound, where the swelling is either ... from 0 to 1 / 0, 2/ 0, 3/0, etc., and the smaller the size of the suture the milder would often be the inflammatory process due to reduced foreign body reaction [2, 5]. Acc...

Ngày tải lên: 03/11/2012, 11:52

... specialized in their efficiency to transport different nuclear proteins [59]. It will be interesting to analyze the binding specificity of the different types of importin a toNLD-INLSandtothe putative ... 3G,H,J). NLD-I domain binds to importin a The previous data suggest that the import of the PTB NLS might be mediated by cytosol receptor like the importin a/b complex. The...

Ngày tải lên: 18/03/2014, 01:20

... of the active site. In this hypothesis, the environment of the cofactor is more hydrated in the low- pH conformation. Thus, the increased polarity favors the 420 nm-ketoenamine tautomer in the ... but ultimately tight, binding of PLP to the apoenzyme in vitro and for the fact that preparations of the mutant enzymes are always largely as apoenzyme. Similarly, inflexibility...

Ngày tải lên: 31/03/2014, 08:20

... 11.0. Finally, confirmatory factor analysis (CFA, using the soft- ware program EQS) was used to calculate the parameters of the observation item and the scales constituted by the rest of the items in the ... between the memory effect and a true change in the severity of depressive symptoms (remission or regression). After all, the more days between the ratings, the m...

Ngày tải lên: 08/08/2014, 21:20

Ngày tải lên: 09/08/2014, 01:21

... adrenergic receptors, and are innervated by auto- nomic nerves, we hypothesized that the vascular responses to autonomic stimulation may be reduced in the NOD mice. To test this hypothesis, we measured ... [28]. In autoimmune diseases, vascular cells can actively contribute to the inflammatory cytokine-dependent network in the blood vessel wall. By interaction with invading cell...

Ngày tải lên: 09/08/2014, 01:22

... antibodies to SSB/La ribonucle- oproteins [3]. Disease in the fetus is entirely independent of whether the mother has systemic lupus erythematosus or Sjögren’s syndrome, or is totally asymptomatic ... and cytokine secretion may vary, these scavengers phagocytose both nonopsonized and opsonized apoptotic cells. Concomi- tantly or alternatively, macrophages may present antigen to lympho...

Ngày tải lên: 09/08/2014, 01:22