Báo cáo y học: "The regulation of endocytosis by kinases: cell biology meets genomic" pps

... research Minireview The regulation of endocytosis by kinases: cell biology meets genomics Zita Balklava and Barth D Grant Address: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, ... eukaryotic cells. Endocytosis mediates a plethora of biological processes including nutrient uptake, regulation of growth factor recep- tors, synapti...

Ngày tải lên: 14/08/2014, 16:20

... I collagen is induced by Ets-1 but repressed by Fli-1 [30,34,42]. In the current study, the induction of the CCN2 promoter in response to TGFβ is reduced by Fli-1, and dimin- ished by dominant negative ... properly cited. Abstract CCN2 is encoded by an immediate-early gene induced in mesenchymal cells during the formation of blood vessels, bone and connective tissue. It plays ke...

Ngày tải lên: 09/08/2014, 07:20

... details 1 Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan. 2 Department of Cardiovascular, Thoracic, and Pediatric Surgery, Yamagata University School of ... 1771:793-806. 12. Takeishi Y, Goto K, Kubota I: Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy. Phar...

Ngày tải lên: 10/08/2014, 09:21

... 0), because many members of this cohort in the United States never did. Disease history was obtained by asking each respondent whether they had ever been told by a physician that they had arthritis ... if they were often bothered by pain. Each of these was reflected in a binary marker coded 1 for yes and 0 for no. In addition, we included a set of dummy varia- bles to capture the...

Ngày tải lên: 13/08/2014, 14:20

... School of Medicine, Pittsburgh, Pennsylvania, USA 2 Assistant Professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 3 Professor, ... G: Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema. Crit Ca...

Ngày tải lên: 13/08/2014, 20:21

... Hung YC, Yeh KT, Yan PS, Lai YY, Sun HS, Lu YJ, Chang YS, Tsai SJ, Huang TH, Leu YW: DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochem Biophys ... [1,2]. However, in muscle cells, Trip10 inhibits glucose uptake by increasing Glut4 endocytosis [3,4]. In natural killer cells, Trip10 regulates actin cytoskeleton dynamics by interact...

Ngày tải lên: 10/08/2014, 05:21

... stress by redirect- ing t he synthetic machinery towards the synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA ... Fe-hydrogenases HydA of C. reinhardtii, the first isolated gene encoding a hydrogenase of a photosynthetic eukaryotic cell, repre- sents a novel type of Fe-hydrogenases. Parts of...

Ngày tải lên: 08/03/2014, 22:20

... mediated primar- ily by chondrocytes, by synovial fibroblasts and on occa- sion, by osteoclasts [7,10–12]. The interstitial collagens (types I, II and III), are the princi- ple targets of destruction, ... usually produced only by cartilage and bone during development, and by chondro- cytes in osteoarthritis (OA) [6–8]. Expression of MMPs is low in normal cells, and these low lev...

Ngày tải lên: 09/08/2014, 03:24

... divided by the total time of translation of the mRNA, or 1/tAI of the entire gene). We first analyzed 154 synthetic GFP genes in a library constructed by K udla et al. [13]. All the synthetic ... Pilpel Genome Biology 2011, 12:R12 http://genomebiology.com/2011/12/2/R12 Page 4 of 10 location divided by the length of the gene, and the rela- tive strength is the strength divide...

Ngày tải lên: 09/08/2014, 22:23

... pres- ence of PI (Figure 4a). It is thus highly unlikely that MMP- 1 mRNA stability is significantly affected by PI. Proteasome inhibition activates the MMP-1 promoter by inducing binding of c-Jun ... maintains cell homeostasis by promoting clearance of damaged or improperly folded proteins and degrades key components involved in the cell cycle and cell signaling [20]. We r...

Ngày tải lên: 12/08/2014, 12:20