Báo cáo y học: "Phosphoproteomics: new insights into cellular signaling" pptx
Báo cáo y học: "Phosphoproteomics: new insights into cellular signaling" pptx
... and the discovery of new phos-
phorylation sites in known signaling proteins. As enzymatic
catalysis by protein kinases is the only known physiological
mechanism for phosphorylation of serine, ... The availabil-
ity of genome databases and advancements in analytical
technology, especially mass spectrometry, has made it
possible to study many phosphoproteins and phosphorylation
sites at ......
Báo cáo y học: " Mathematical model insights into arsenic detoxification" pptx
... metabolism t hat affect methylation, such as the inhibition of the
methylation reactions by S-adenosylhomocysteine and the inhibition of glycine methyl-
tranferase by 5-methyltetrahydrofolate. The fact ... University, 722 West 168th Street, New York, NY 10032, USA.
4
Department of Environmental Health
Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street, Ne...
Báo cáo y học: "Genome-wide insights into eukaryotic transcriptional control" doc
... complete redundancy, quantitative redun-
dancy, and incongruent redundancy. e latter category
was unexpected yet is relatively common and can arise
from partial redundancy between two factors ... treatment. e sensi-
tivity of this approach meant that they could identify
about tenfold more protein-coding genes rapidly
regu lated by estrogen than did microarrays. Moreover,
the data revea...
Báo cáo y học: "A new journal... on spindle cells" pptx
... a
trusted quality and may also summarise the evidence,
and/or host expert discussions about it. This journal
may well serve the new dissemination requirements of
innovative ways to develop new therapies ... Central and other full-text
repositories. A widely accessible journal of this type may
become a key resource for the worldwide sarcoma com-
munity, filling some of the gaps in medical...
Báo cáo y học: "A new era for proteomics research" pptx
... interaction analysis for proteome-wide efforts.
Tony Pawson (University of Toronto, Canada) is using a
combination of classical cell biology techniques with quanti-
tative mass spectrometry to study signaling ... the difficulty of a gene-centric
approach for mass spectrometry, whereas such an approach
is more feasible for antibody- and interaction-based analysis.
The shortcomings of previous...
Báo cáo y học: "Arrestins: ubiquitous regulators of cellular signaling pathways" pdf
... photoreceptor types in the retina, although both
are also present in pinealocytes. The intracellular concentra-
tion of rod arrestin in rod photoreceptors is enormous (over
100 M) [58]. Virtually every mammalian ... predomi-
nantly cytoplasmic, whereas the subcellular distribution of
arrestin2 varies: for example, it is more abundant in the
cytoplasm of striatal neural precursors and neurons...
Báo cáo y học: " Translating research evidence into clinical practice: new challenges for critical care" pdf
... respiratory distress
syndrome. New Horiz 1993, 1:593-602.
10. Hannan EL, Siu AL, Kumar D, Kilburn H Jr, Chassin MR: The
decline in coronary artery bypass graft surgery mortality in
New York State. ... administration or by key
members of the health care system. For example, although
the clinicians may wish to use a new and highly effective
therapy, the pharmacy may be reluctant to stock...
Báo cáo Y học: O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines Distinct specificity of GalNAc-transferase isoforms pot
... transferred N-acetylgalactosamine into
the second Thr residue only when N-acetylgalactosamine
was attached to the third one.
Keywords: O-glycosylation; mucin; polypeptide N-acetylga-
lactosaminyltransferase; ... UDP-GalNAc.
Biosynthesis of O-glycans is mediated by the step-wise
addition of monosaccharides by a variety of glycosyl-
transferases, where topology and kinetic properties of
Golgi...
Báo cáo Y học: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx
... SOCS-3.
Peptide K
d
(l
M
)
pY343 > 30
pY401 9.5 ± 0.12
pY429pY431 1.1 ± 0.03
F429pY431 4.6 ± 0.02
pY429F431 4.9 ± 0.02
Y4 2 9Y4 31 ND
pY443 ND
pY461pY464 ND
Y4 61pY464 ND
pY46 1Y4 64 ND
pY479 ND
Ó FEBS 2002 ... L93A and R94E with the peptide
pY429pY431 (pYpY). (B) Precipitation of SOCS-3 WT or SOCS-3
R94E with the peptides pY429pY431 (pYpY), pY429F431 (pYF) and
F429pY431 (FpY).
2522 M. H...
Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... mutation at
the 597 position), GST– cyto -Y6 41F (Y! F mutation at the
641 position), GST– cyto -Y6 67F (Y !F mutation at the 667
position), GST– cyto -Y6 91F (Y! F mutation at the 691
position), and ... fusion
constructs. Tyrosine phosphorylation (minus GST alone) of GST–
cyto-wt with individual tyrosine kinases in a cell-free format.Tyrosine
phosphorylation of GST–cyto-wt and GST–cytoY !F...
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