Báo cáo y học: "Genomic analysis of heat-shock factor targets in Drosophila" doc

... vessels following lung injury by V 2 O 5 . Polypeptide growth factors have a variety of functions in airway remodeling that occurs after metal-induced lung injury. Our genomic analysis identified ... play important roles in various aspects of tissue injury, repair, and remod- eling. These categories included A) cytokines and chemok- ines, B) growth factors, C) STAT signaling, D) cel...

Ngày tải lên: 12/08/2014, 15:20

... possibility of using naturally occurring genetic variation as a means of generating perturbations, with the advantage of allowing identification of the individual genetic factors affecting the trait of ... We Significantly differentially regulated pathways identified by GSEA analysisFigure 1 Significantly differentially regulated pathways identified by GSEA analysis. The histogram...

Ngày tải lên: 14/08/2014, 14:21

... accurate measure of Hsf 'binding affinity' or that simple binding site prediction is not a reliable way of identifying genuine HSEs. Comparative analysis Two genome-wide studies in the budding yeast ... in yeast to determine what fraction of the 165 Hsf targets they identified by ChIP showed evidence of induction by heat shock. Only 7% of the putative Hsf targets...

Ngày tải lên: 14/08/2014, 14:21

... Both synonymous and nonsynonymous sites were examined for the coding regions of each gene. Additionally, because regulatory elements are often found in first introns, levels of polymorphism in the ... cut-offs are arbitrary and chosen because they resulted in about half of the genes falling into 'average' gene expres- sion and the remainder of the genes falling roughly...

Ngày tải lên: 14/08/2014, 20:22

... example of how CRM finding can precede motif-finding in cis-regulatory analysis, rather than rely on prior knowledge or discovery of the motifs. A thorough inves- tigation of this claim, using many ... level of similarity in terms of the collection of binding sites present within, and this similar- ity may be the basis for their computational discovery ab ini- tio. This gives...

Ngày tải lên: 14/08/2014, 08:20

... assembly Polar granule 152721 T, L, L × T, r Imaginal disc growth factor 1 36A1 Imaginal disc growth factor activity; NOT chitinase activity; hydrolase activity, hydrolyzing N-glycosyl compounds Cell-cell ... L, r Arrestin 1 36D3 Metarhodopsin binding G-protein coupled receptor protein signaling pathway; deactivation of rhodopsin mediated signaling; endocytosis; intracellular...

Ngày tải lên: 14/08/2014, 14:21

... least 64. In the combined analysis of the nine microarrays, P values were adjusted for multiple testing to control the false discovery rate [13] or the type I family wise error rate by applying the ... normalized by applying the Lowess intensity-dependent normalization method [46], and statisti- cally analyzed using the Almazen System software (Alma Bioinformatics SL, Madrid, Spain). Th...

Ngày tải lên: 14/08/2014, 08:20

... to identify key molecules in the course of hy- poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into the mechanisms of preeclampsia ... regulation of the JNK gene, but by modulating phos- phorylation of JNKs. Thus, Bag-1 may inhibit apop- tosis by suppressing the expression of Bid and Bad. Bag-1 may also e...

Ngày tải lên: 31/10/2012, 15:12

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 he...

Ngày tải lên: 31/10/2012, 16:49

... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... in thymocytes with age. As shown in Table 4, real time RT-PCR confirmed the increased levels of many of these genes identified in the array analysis. Moreover, Western bl...

Ngày tải lên: 03/11/2012, 11:35