Báo cáo y học: "High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae" pptx

... example of how CRM finding can precede motif-finding in cis -regulatory analysis, rather than rely on prior knowledge or discovery of the motifs. A thorough inves- tigation of this claim, using many ... pattern of the adjacent gene. Discovery and analysis of CRMs is, therefore, a crucial step in understanding gene regulatory networks in the fruitfly and, more generally,...

Ngày tải lên: 14/08/2014, 08:20

... and Back Pain Survey - The prevalence of low back pain and related disability in Saskatchewan adults. Spine 1998, 23(17):1860-1867. 5. Volinn E: The epidemiology of low back pain in the rest of the world. ... Canberra , University of Sydney and the Australian Institute of Health and Welfare; 1999. 14. Frymoyer J, Cats-Baril W: An over-view of the incidences and costs of low...

Ngày tải lên: 13/08/2014, 13:22

... to find intein insertions by the TIGRFAM profiles TIGR01445 (intein amino terminus) and TIGR01443 (intein carboxyl terminus) [65], but none of these fragments had a detectable intein domain. In ... studies are increasingly revealing the huge genetic diversity of marine viruses. In this study, we used a new approach - 'phylogenetic mapping' - to obtain a comprehensive picture...

Ngày tải lên: 14/08/2014, 20:22

... to identify key molecules in the course of hy- poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into the mechanisms of preeclampsia ... regulation of the JNK gene, but by modulating phos- phorylation of JNKs. Thus, Bag-1 may inhibit apop- tosis by suppressing the expression of Bid and Bad. Bag-1 may also e...

Ngày tải lên: 31/10/2012, 15:12

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 he...

Ngày tải lên: 31/10/2012, 16:49

... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... in thymocytes with age. As shown in Table 4, real time RT-PCR confirmed the increased levels of many of these genes identified in the array analysis. Moreover, Western bl...

Ngày tải lên: 03/11/2012, 11:35

... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain. Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64. Groups of four mice were injected intramuscularly ... DM64 binds to the myotoxins through a myotoxic/ cytolytic site distinct from the catalytic site, as already described for the inhibition of myotoxicity by heparin [44]. At...

Ngày tải lên: 21/02/2014, 01:21

... [66], and disassembly of active units from an oligomeric (storage) state of a-crystallin was proposed, upon structural analysis of aA-crystallin by site- directed spin labelling, as a model for ... Mchaourab, H.S. (1999) Folding pattern of the a-crystallin domain in aA-crystallin determined by site-directed spin labelling. J. Mol. B iol. 294, 561–577. 68. To ¨ ro ¨ k, Z., Goloubin...

Ngày tải lên: 22/02/2014, 04:20

... encoding amino acidic sequences at the ends of each of the putative four main tTG domains, as outlined by [9] and substantially confirmed by [10], were used to amplify these domains. The scheme of ... belongs to a family of enzymes that catalyze protein cross-linking reac- tions and is constitutively expressed in many tissues as well as being activated during apoptosis. In a recent...

Ngày tải lên: 08/03/2014, 09:20

... carrying four acyl residues. GlcN residue A had unsubstituted hydroxyl group at C-1, and was mostly present in an a-pyranose form. Acyl 1 ,acyl 2 and acyl 3 residues had hydroxy or acyloxy groups ... 2-N-(3-O- acyl 4 -acyl 2 )-b-GlcN-(1–6)-2-N-acyl 1 )3-O-acyl 3 -GlcN where acyl 1 ,acyl 2 and acyl 3 are 3-hydroxyhexadecanoic or 3-hy- droxyoctadecanoic acids, acyl 4 is tetradecanoic or (mino...

Ngày tải lên: 08/03/2014, 09:20