Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx

... 5). Protein interaction analysis reveals a novel pathway involved in the response to cadmium In order to further define the molecular mechanisms of the cadmium defense response, the program Cytoscape ... when the expression of only one of the redundant genes is affected. By integrating the RNAi assay results into the protein interac- tion network, a...

Ngày tải lên: 14/08/2014, 07:21

... upon activation of the insulin and wingless pathways in S2 cells Binding of insulin-like peptides to the insulin receptor in Drosophila cells leads to the activation of dPI3 kinase, which http://genomebiology.com/2009/10/1/R11 ... crosstalk with other signaling pathways. For example, patterning of the wing imaginal disc is achieved mainly through the interplay...

Ngày tải lên: 14/08/2014, 21:20

... thymocytes when compared to the young by real-time RT-PCR (Figure 5). These genes thus may be a contrib- uting factor to the increase in B cells, both in total number and in maturity, within the ... group of genes warranting further scrutiny. In order to obtain an expression profile of the genes which changed the most with age, we uploaded all of our...

Ngày tải lên: 03/11/2012, 11:35

... is indicated by the four rows of segments at the top. The first row, continuing to the third row, represents the upper RP11 haplotigs in Figure 5 and the second row, continuing to the fourth row, ... results close gap 3 and clearly show that the beginning of NT_078094 is directly connected to the beginning of NT_026446 (Figure 4c). One of these contigs i...

Ngày tải lên: 14/08/2014, 07:21

... potentially contribute to proteome diversity? The majority of exonizations in our dataset inserted an in- frame stop codon within the CDS (in 61% to 84% of the cases); in 9% to 24% of the cases they ... new introns [20]. In only two cases is the origin of the intron known: a SINE insertion that gave rise to a new intron in the coding region of the...

Ngày tải lên: 14/08/2014, 07:21

... T-brachyury, MESP1). Further examination of the data set identified multiple genes involved in the BMP signaling pathway in the differentiation of blood and endothelial cells. These genes include ... 1). To summarize, comparing BCs to leukocytes identified genes involved in vas- culogenesis, to endothelial cells identified genes involved in hematopoiesi...

Ngày tải lên: 14/08/2014, 08:20

... types of components, or nodes: the genes involved in the system and the TFs that regulate their expression. Protein-protein interactions between TFs and protein-DNA interactions between TFs and their ... in DNA-binding, includ- ing SAND [28], and THAP zinc-finger [29] domains. For sev- eral of the domains unique to wTF2.0 (CP2, WH-DAC, IPT/ TIG, TEA/ATTS, WT1, Y...

Ngày tải lên: 14/08/2014, 16:20

... presence of citrullinated fibrin in the synovial membrane of RA patients [17] and the use of cit- rullinated fibrinogen to assay the serum antibodies to deimi- nated fibrinogen (anti-human citrullinated ... cyclic citrullinated peptide. Figure 3 Dendrogram of the cluster analysis of the different ACPA assays in population 2Dendrogram of the cluster analysi...

Ngày tải lên: 09/08/2014, 08:22

... participated in designing the study, collection and analysis of data, and helped to draft the manuscript. MK participated in designing the study, and collection and statistical analysis of data. ... arrest was induced by asphyxia. In this study the Pet CO 2 values during CPR were initially high, then decreasing to subnormal levels and then increasing again...

Ngày tải lên: 13/08/2014, 11:22

... promptly signals the return of spontaneous circulation [2]. PetCO 2 is likely to promptly identify asphyxia, in contrast to primary cardiac causes of arrest as previously reported by one of the ... doubling of the response time of professional rescuers, presumably in the absence of bystander utilization of automated external defibrillators, especially since a ma...

Ngày tải lên: 13/08/2014, 11:23