Báo cáo y học: " Gene expression variation in Down''''''''s syndrome mice allows prioritization of candidate genes" potx

... we investigated the variation of expression levels for the mmu21 genes in the eight trisomic and control mice. Variation of gene expression in the brains of Ts65Dn and control mice Analysis of ... properly cited. Variation in Down syndrome genes<p>RNA from eight Ts65Dn mice (a model of Down syndrome) and eight euploid mice were analysed by real-tim...

Ngày tải lên: 14/08/2014, 07:21

... by two probes, showing 1.24-fold and 1.18-fold over -expression in European flies), indicating that not only DNA polymorphism, but also variation in expression plays a role in the interaction of ... within each hybridization (that is, rand- omizing within a column), thereby maintaining the underly- ing data structure (for example, missing data) within each hybridization. Random s...

Ngày tải lên: 14/08/2014, 08:20

... pathway analyses indicated that these genes were characterized by a distinct signature made of genes involved in the regulation of the cell cycle (28% of the GO annotated genes) and genes involved in ... expression of 1,058 genes in a subset of four patients with positive syno- vial immunostaining for TNF-α. These genes were enriched in families of genes involved in in...

Ngày tải lên: 09/08/2014, 14:20

... [6,21]. Gene expression profiling of arthritic rat joints revealed a spectrum of genes exhibiting extensive inflammatory activ- ity, infiltration of activated cells, angiogenesis, regulation of apoptosis ... shown in previous studies [10,11], analysis of gene expression profiles by processing whole homogenized joints can provide useful information about dysregulated genes,...

Ngày tải lên: 09/08/2014, 06:22

... represented by genes encoding interleukins, chemokine receptors and ligands, and by those involved in antigen recognition and processing. Keywords: DNA expression array, differential gene expression, inflammation, ... the relatively late diagnosis of RA, the large variety of cell types (cells of the immune system and of synovial joints) involved in autoimmune arthritic proces...

Ngày tải lên: 09/08/2014, 06:22

... upstream of BCL-2 (Figure 2), may enhance their binding to BCL-2, thereby inhibiting the anti-apop- totic function. Thus, we analyzed the BCL-2 protein expression level by flow cytometry in Molt-4 ... × difference lines, indicated by black arrows, represent differentially expressed genes. The farther from the line, the greater the difference in gene expression are. (D) Analysis o...

Ngày tải lên: 10/08/2014, 21:23

... in systemic sclerosis are only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression in patients ... cells. The gene array data concerning the drug modulation of genes involved in the control of apoptosis, in cell adhe- sion and in vasculogenesis were validated by...

Ngày tải lên: 12/08/2014, 14:22

... anchoring of the gene expression data and confirm that the goal of the study to evoke different types of liver injury was achieved. Gene expression levels in whole blood were also assayed to evaluate whether ... discriminated or classified in rodent model systems by microarray profiling of gene expression alterations in the target tissues, that is, tis- sues that dis...

Ngày tải lên: 14/08/2014, 20:22

... scrutiny, or their hybrids. Clearly, expression in hybrids is made very complex, for instance, by the generation of a large quantity of abnormal heteromeric proteins [13]. Therefore, analyzing expression ... the interval defined by the two lines. The expression of these genes was presumably driven to a SEG expression level by their cis-elements of SEG origin. Only six gen...

Ngày tải lên: 14/08/2014, 20:22

... central hypothesis in Down -syndrome research is that gene dosage results in a 50% increase in expression of genes on chromosome 21q, and that this directly or indirectly alters the timing, pattern ... similar increases. Indeed, of the 37 genes, only 24 showed increases in 18 or more of the 36 possible pairs. Because these mice are maintained on an inbred background (C57B...

Ngày tải lên: 14/08/2014, 14:21