Báo cáo y học: " Gene expression variation in Down''''''''s syndrome mice allows prioritization of candidate genes" potx
Báo cáo y học: " Gene expression variation in Down''''s syndrome mice allows prioritization of candidate genes" potx
... we investigated the variation of expression levels for the mmu21 genes in the eight trisomicand control mice. Variation of gene expression in the brains of Ts65Dn and control mice Analysis of ... properly cited. Variation in Down syndrome genes<p>RNA from eight Ts65Dn mice (a model of Down syndrome) and eight euploid mice were analysed by real-time PCR to examine inter-individual gene ... stratification of populations by expression profiling provides an essential dimension in the molecularanalysis of aneuploidy syndromes. Identifying the pathwaysthat are perturbed by trisomy will require...
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Báo cáo y học: "Gene expression variation in African and European populations of Drosophila melanogaster" potx
... bytwo probes, showing 1.24-fold and 1.18-fold over -expression in European flies), indicating that not only DNApolymorphism, but also variation in expression plays a role in the interaction of ... within each hybridization (that is, rand-omizing within a column), thereby maintaining the underly-ing data structure (for example, missing data) within eachhybridization. Random sampling ... employed a two-node analysis (see Materials and methods), in which allstrains from each population were grouped into a single node.An interesting finding was that genes encoding proteinsinvolved...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... pathway analysesindicated that these genes were characterized by a distinctsignature made of genes involved in the regulation of the cellcycle (28% of the GO annotated genes) and genes involved in ... expression of 1,058 genes in a subset of four patients with positive syno-vial immunostaining for TNF-α. These genes were enriched in families of genes involved in inflammatory processes.Clinicians ... dif-ferentially expressed between T0 and T12. Interestingly, thelatter genes clustered in two distinct families: genes involved in the regulation of immune responses and genes involved in the regulation of...
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Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx
... [6,21]. Gene expression profiling of arthritic rat joints revealed aspectrum of genes exhibiting extensive inflammatory activ-ity, infiltration of activated cells, angiogenesis, regulation of apoptosis ... shown in previous studies[10,11], analysis of gene expression profiles by processingwhole homogenized joints can provide useful informationabout dysregulated genes, not only in synoviocytes ... coordinated gene expression in injured tissue.Further bioinformatic analysis of the data to examine cellmarkers, and genes whose expression may correlate withthem, in combination with analysis...
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Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... represented bygenes encoding interleukins, chemokine receptors and ligands,and by those involved in antigen recognition and processing.Keywords: DNA expression array, differential gene expression, inflammation, ... therelatively late diagnosis of RA, the large variety of cell types(cells of the immune system and of synovial joints) involved in autoimmune arthritic processes, and the extreme geneticheterogeneity of ... thesynovial/joint cells of recipient mice that lack an adaptiveimmune system. The list of genes we present in this studyis rather short; that is, it includes only genes profoundlyaffected during...
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Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt
... upstream of BCL-2 (Figure 2), may enhancetheir binding to BCL-2, thereby inhibiting the anti-apop-totic function. Thus, we analyzed the BCL-2 protein expression level by flow cytometry in Molt-4 ... ×difference lines, indicated by black arrows, represent differentially expressed genes. The farther from the line, the greater the difference in gene expression are. (D) Analysis of pathways closely related ... profile analysis using an Affymetrix HG U133 Plus2.0 gene chip (Shanghai Biochip Co., Ltd., Shanghai,China). The Affymetrix microarray analysis was per-formed using Gene Spring GX10.0 software...
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Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx
... in systemic sclerosis are only partiallyknown. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprostinfusion and gene expression in patients ... cells.The gene array data concerning the drug modulation of genes involved in the control of apoptosis, in cell adhe-sion and in vasculogenesis were validated by quantitativeRT-PCR of selected genes ... details1Section of Internal Medicine B, Department of Medicine, University of Verona, P.le LA Scuro, 10, 37134, Verona, Italy.2Immunology Unit, Institute G.Gaslini, Largo G. Gaslini, 16147, Genova, Italy.3Section...
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Báo cáo y học: "Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype" ppsx
... anchoring of the gene expression data and confirm that the goal of the study toevoke different types of liver injury was achieved. Gene expression levels in whole blood were also assayed to evaluatewhether ... discriminated orclassified in rodent model systems by microarray profiling of gene expression alterations in the target tissues, that is, tis-sues that display visible adverse effects in response ... site of the injury whereas the blood represents a readily available tis-sue source functioning as a surrogate (Table 3). Cumulatively,these findings reinforce the utility of performing gene...
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Báo cáo y học: " Gene expression regulation in the context of mouse interspecific mosaic genomes" pdf
... scrutiny, or their hybrids. Clearly, expression in hybrids is made very complex, for instance, bythe generation of a large quantity of abnormal heteromericproteins [13]. Therefore, analyzing expression ... the interval defined by the two lines. The expression of these genes was presumably driven to a SEG expression level by their cis-elements of SEG origin. Only six genes were really dysregulated ... mapping of fertility traits using interspecific recombinant congenic mice. Genetics 2007, 176:1907-1921.30. Good JM, Handel MA, Nachman MW: Asymmetry and polymor-phism of hybrid male sterility...
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Báo cáo y học: "Gene-dosage effects in Down syndrome and trisomic mouse models" pot
... central hypothesis in Down -syndrome research is that gene dosage results in a 50% increase in expression of genes on chromosome 21q, and that thisdirectly or indirectly alters the timing, pattern ... similar increases. Indeed, of the 37 genes, only24 showed increases in 18 or more of the 36 possible pairs.Because these mice are maintained on an inbred background(C57BL/6J), the only genetic ... expression. Because analyses of cases of Down syndrome that are due topartial trisomies of chromosome 21q have not eliminated anysignificant segment of 21q from containing genes potentiallyimpacting...
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