Textbook of Interventional Cardiovascular Pharmacology - part 3 docx
Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... intravenous infusion, plasma concentrations at steady
Chapter 005. Principles of Clinical
Pharmacology
(Part 3)
Clinical Implications of Altered Bioavailability
Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared
to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can
result in exposure...
Seventy Years of Exploration in Oceanography Part 3 docx
... which advocated timing the opening and closing of the Gates to flush the
lagoon by rectifying the lagoon circulation
H. von Storch, K. Hasselmann, Seventy Years of Exploration in Oceanography 11
DOI ... job of predicting Hawaii waves a few days later, and for a moment might have
entertained the idea of going into the wave forecasting business. However at that
time the economi...
The Welding of Aluminum & Its Alloys Part 3 docx
... 535 6
6082 40 43 51 83
5454 535 6 535 6 535 6
5251 535 6 535 6 5056
50 83 535 6 535 6
5005 535 6
31 03 535 6 231 9 535 6 535 6 535 6 5556 5556
31 05 NS 40 43 5056 535 6
40 43 40 43
2219 231 9 231 9
40 43
1050 40 43 231 9
1080 ... 231 9 231 9 231 9 231 9
31 03 40 43 1050 1050 40 43 1050
5052 535 6 535 6 5554 535 6 535 6
50 83 51 83 535 6 51 83 535 6 535 6
5086 535 6 535 6 51...
Textbook of Traumatic Brain Injury - part 3 pot
... sense” with re-
202 TEXTBOOK OF TRAUMATIC BRAIN INJURY
lower socioeconomic classes in their 30 s. The principal
cause of brain injury was motor vehicle accidents. The
majority of patients (68%) ... neuropsychia-
tric evaluation and treatment of the patient with trau-
matic brain injury (TBI).
Role of the Neuropsychologist
In the traumatically brain- injured popula...
Textbook of Interventional Cardiovascular Pharmacology - part 1 doc
... systems (9 ,10 ).
Removal of fibrinopeptide A leads to end-to-end fibrin poly-
merization whereas loss of fibrinopeptide B allows
side-to-side polymerization of the end-to-end linked
monomers (11 ). It ... levels of endothelin -1 (ET -1 ) , an extremely potent
14 An overview of hemostasis and thrombosis
11 80 Chap 01 3 /14 /07 6:34 PM Page 14
Alexandre C. Abizaid MD PhD
Insti...
Textbook of Interventional Cardiovascular Pharmacology - part 2 docx
... the
presence of a radical H instead of CO
2
CH
3
in the molecule.
2. Clopidogrel (SR 25 990) (Plavix
đ
Sanofi-Aventis) is the
hydrogen sulfate salt of the S enanthiomer of methyl 2- ( 2-
chlorophenyl ) -2 -[ 4,5,6,7-tetrahydrothieno(3,4-c)pyridine-
5-yl] ... product of the lipoxyge-
nase pathway, 5-oxo-6,8,11,14-eicosatetraenoic acid
(5-Oxo-ETE), induces leukocyte chemotax...
Textbook of Interventional Cardiovascular Pharmacology - part 4 pot
... 8.2 Ϯ 0.32 9.1 Ϯ 0 .41 7.6 Ϯ 0. 24

-carotene (RE)
b
377 Ϯ 36 .4 537 Ϯ 51 .4 559 Ϯ 47 .3 522 Ϯ 69.0 5 54 Ϯ 47 .3 507 Ϯ 34. 2
A (RE)
b
878 Ϯ 40 .6 1115 Ϯ 80.2 1117 Ϯ 61.5 961 Ϯ 74. 4 945 Ϯ 52.8 997 Ϯ 58.5
Note: ... absorbance capacity 4 (118)
DMPD N,N-dimethyl-p-phenylenediamine 4 (119)
DPPH 1,1-diphenyl-2-picrylhydrazyl 4 (119)
TRX Thioredoxine and glutaredoxine 4 (120,121)
Ta...
Textbook of Interventional Cardiovascular Pharmacology - part 6 pdf
... proMMP-2
MT2-MMP MMP-15 Activates proMMP-2
MT3-MMP MMP- 16 Activates proMMP-2
MT4-MMP MMP-17 Not known
MT5-MMP MMP-24 Activates proMMP-2
MT6-MMP MMP-25 Not known
Nonclassified MMPs
Matrilysins MMP-7 ... family of peptides
(VEGF-A to -E) of which VEGF-A is the most thoroughly stud-
ied. VEGF-A (more often called just VEGF) occurs in five
isoforms of 121, 145, 165 , 189, and 2 06 amino...
Textbook of Interventional Cardiovascular Pharmacology - part 7 docx
... and low levels of transgene
expression limit this approach. Phospholipid formulae such as
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dode-
canoyl/1,2-dioleoyl-sn- glycero-3-phosphocholine ... intramuscular injec-
tion of recombinant adeno-associated virus-erythropoietin in
monkeys. J Surg Res 2000; 90(2):102–108.
57 Hirata RK, Russell DW. Design and packaging of adeno-associ-
ate...
Textbook of Interventional Cardiovascular Pharmacology - part 8 doc
... failure: analysis of the experience in the MERIT-HF study.
J Am Coll Cardiol 2001; 38: 932–9 38.
29 The-Beta-Blocker-Evaluation -of- Survival-Trial-Investigators.
A Trial of the beta-blocker bucindolol ... 332 :80 85 .
90 CIBIS-II-Investigators-and-Committees. The Cardiac Insuffi-
ciency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet
1999; 353:9–13.
91 Beta-Blocker-Evaluatio...
Textbook of Interventional Cardiovascular Pharmacology - part 9 pot
... Lancet 199 7;
3 49( 9063):14 29 1435.
29 The EPISTENT Investigators. Randomised placebo-controlled
and balloon-angioplasty-controlled trial to assess safety of
coronary stenting with use of platelet ... Thromb
Haemost 199 9; 82:507.
34 Afshar-Kharghan V, Khoshnevis-Als M, Lopez J. A Kozac
sequence polymorphism is a major determinant of the surface
levels of a platelet adhesion recep...
Textbook of Interventional Cardiovascular Pharmacology - part 10 pps
... (2,12)
of 40 hrs (1); min (7)
dose-dependent,
47 hr for 5 mg
dose (15)
For vitamin K
dependent clotting
factors: II-60 hr,
VII-4–6 hr,
IX-24 hr,
X-4 8-7 2 hr (1)
Return to 4–5 days for INR 10 ... to half-life of anti-Xa activity following SC injection.
b
The platelet-inhibitory effects of aspirin last the lifetime of the platelet, due to irreversible inactivation of platele...
Textbook of Interventional Cardiovascular Pharmacology phần 3 potx
... J Thromb Haemost 2005; 3: 130 9– 131 1.
38 Vane Jr. Inhibition of prostaglandin syntheses as a mechanism
of action for aspirin-like drugs. Nat New Biol 1971;
231 : 232 – 235 .
39 Roth GJ, Stanford N, ... NSAIDs
Saratin
Clopidogrel
Ticlopidine
Prasugrel
AR-C6 933 1MX
Collagen
ADP
Serotonin
IVIg
R-96544
Sarpogrelate
AT-1015
Phosphodiesterase
Cyclooxygenase-1
Dipyridamole, cilostazol
BM-...
Textbook of Interventional Cardiovascular Pharmacology - part 3 docx
... Med 19 83; 30 9:
39 6–4 03.
33 Cairns JA, Gent M, Singer J, et al. Aspirin, sulfinpyrazone or both
in unstable angina: results of a Canadian multicenter trial. N Engl
J Med 1985; 31 3: 136 9– 137 5.
34 Theroux ... 110:1916–1919.
References 1 53
1180 Chap 13. qxd 3/ 14/07 11:26 AM Page 1 53
of activated clotting time (ACT) Ͻ170 seconds. INRs were
1.9, 2.6, 3. 2, and 3. 8 in the f...
Textbook of Interventional Cardiovascular Pharmacology - part 5 pps
... Scheerder (18) 2000 Self-designed PFM-P 75 Pig coronary Ibuprofen 10 15 àg PFM-P 75 No
art in 5% (g/g)
Valsartan 20 25 àg PFM-P 75 No
in 10% (g/g)
De Scheerder (18) 2000 Self-designed PFM-P 75 Pig coronary ... Self-designed PFM-P 75 Pig coronary MP Dipcoating: PFM-P 75 Yes
art 10 15 àg in
5% (g/g)
20 25 àg in
10% (g/g)
Spraycoating PFM-P 75 Yes
100 150 àg
in 9% (g/g)
400 450 àg...