Textbook of Interventional Cardiovascular Pharmacology - part 3 docx

... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure...

Ngày tải lên: 06/07/2014, 08:20

... which advocated timing the opening and closing of the Gates to flush the lagoon by rectifying the lagoon circulation H. von Storch, K. Hasselmann, Seventy Years of Exploration in Oceanography 11 DOI ... job of predicting Hawaii waves a few days later, and for a moment might have entertained the idea of going into the wave forecasting business. However at that time the economi...

Ngày tải lên: 05/08/2014, 21:21

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Ngày tải lên: 10/08/2014, 12:21

... sense” with re- 202 TEXTBOOK OF TRAUMATIC BRAIN INJURY lower socioeconomic classes in their 30 s. The principal cause of brain injury was motor vehicle accidents. The majority of patients (68%) ... neuropsychia- tric evaluation and treatment of the patient with trau- matic brain injury (TBI). Role of the Neuropsychologist In the traumatically brain- injured popula...

Ngày tải lên: 10/08/2014, 18:20

... systems (9 ,10 ). Removal of fibrinopeptide A leads to end-to-end fibrin poly- merization whereas loss of fibrinopeptide B allows side-to-side polymerization of the end-to-end linked monomers (11 ). It ... levels of endothelin -1 (ET -1 ) , an extremely potent 14 An overview of hemostasis and thrombosis 11 80 Chap 01 3 /14 /07 6:34 PM Page 14 Alexandre C. Abizaid MD PhD Insti...

Ngày tải lên: 11/08/2014, 11:22

... the presence of a radical H instead of CO 2 CH 3 in the molecule. 2. Clopidogrel (SR 25 990) (Plavix đ Sanofi-Aventis) is the hydrogen sulfate salt of the S enanthiomer of methyl 2- ( 2- chlorophenyl ) -2 -[ 4,5,6,7-tetrahydrothieno(3,4-c)pyridine- 5-yl] ... product of the lipoxyge- nase pathway, 5-oxo-6,8,11,14-eicosatetraenoic acid (5-Oxo-ETE), induces leukocyte chemotax...

Ngày tải lên: 11/08/2014, 11:22

... 8.2 Ϯ 0.32 9.1 Ϯ 0 .41 7.6 Ϯ 0. 24 ␤ -carotene (RE) b 377 Ϯ 36 .4 537 Ϯ 51 .4 559 Ϯ 47 .3 522 Ϯ 69.0 5 54 Ϯ 47 .3 507 Ϯ 34. 2 A (RE) b 878 Ϯ 40 .6 1115 Ϯ 80.2 1117 Ϯ 61.5 961 Ϯ 74. 4 945 Ϯ 52.8 997 Ϯ 58.5 Note: ... absorbance capacity 4 (118) DMPD N,N-dimethyl-p-phenylenediamine 4 (119) DPPH 1,1-diphenyl-2-picrylhydrazyl 4 (119) TRX Thioredoxine and glutaredoxine 4 (120,121) Ta...

Ngày tải lên: 11/08/2014, 11:22

... proMMP-2 MT2-MMP MMP-15 Activates proMMP-2 MT3-MMP MMP- 16 Activates proMMP-2 MT4-MMP MMP-17 Not known MT5-MMP MMP-24 Activates proMMP-2 MT6-MMP MMP-25 Not known Nonclassified MMPs Matrilysins MMP-7 ... family of peptides (VEGF-A to -E) of which VEGF-A is the most thoroughly stud- ied. VEGF-A (more often called just VEGF) occurs in five isoforms of 121, 145, 165 , 189, and 2 06 amino...

Ngày tải lên: 11/08/2014, 11:22

... and low levels of transgene expression limit this approach. Phospholipid formulae such as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dode- canoyl/1,2-dioleoyl-sn- glycero-3-phosphocholine ... intramuscular injec- tion of recombinant adeno-associated virus-erythropoietin in monkeys. J Surg Res 2000; 90(2):102–108. 57 Hirata RK, Russell DW. Design and packaging of adeno-associ- ate...

Ngày tải lên: 11/08/2014, 11:22

... failure: analysis of the experience in the MERIT-HF study. J Am Coll Cardiol 2001; 38: 932–9 38. 29 The-Beta-Blocker-Evaluation -of- Survival-Trial-Investigators. A Trial of the beta-blocker bucindolol ... 332 :80 85 . 90 CIBIS-II-Investigators-and-Committees. The Cardiac Insuffi- ciency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 1999; 353:9–13. 91 Beta-Blocker-Evaluatio...

Ngày tải lên: 11/08/2014, 11:22

... Lancet 199 7; 3 49( 9063):14 29 1435. 29 The EPISTENT Investigators. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet ... Thromb Haemost 199 9; 82:507. 34 Afshar-Kharghan V, Khoshnevis-Als M, Lopez J. A Kozac sequence polymorphism is a major determinant of the surface levels of a platelet adhesion recep...

Ngày tải lên: 11/08/2014, 11:22

... (2,12) of 40 hrs (1); min (7) dose-dependent, 47 hr for 5 mg dose (15) For vitamin K dependent clotting factors: II-60 hr, VII-4–6 hr, IX-24 hr, X-4 8-7 2 hr (1) Return to 4–5 days for INR 10 ... to half-life of anti-Xa activity following SC injection. b The platelet-inhibitory effects of aspirin last the lifetime of the platelet, due to irreversible inactivation of platele...

Ngày tải lên: 11/08/2014, 11:22

... J Thromb Haemost 2005; 3: 130 9– 131 1. 38 Vane Jr. Inhibition of prostaglandin syntheses as a mechanism of action for aspirin-like drugs. Nat New Biol 1971; 231 : 232 – 235 . 39 Roth GJ, Stanford N, ... NSAIDs Saratin Clopidogrel Ticlopidine Prasugrel AR-C6 933 1MX Collagen ADP Serotonin IVIg R-96544 Sarpogrelate AT-1015 Phosphodiesterase Cyclooxygenase-1 Dipyridamole, cilostazol BM-...

Ngày tải lên: 14/08/2014, 01:20

... Med 19 83; 30 9: 39 6–4 03. 33 Cairns JA, Gent M, Singer J, et al. Aspirin, sulfinpyrazone or both in unstable angina: results of a Canadian multicenter trial. N Engl J Med 1985; 31 3: 136 9– 137 5. 34 Theroux ... 110:1916–1919. References 1 53 1180 Chap 13. qxd 3/ 14/07 11:26 AM Page 1 53 of activated clotting time (ACT) Ͻ170 seconds. INRs were 1.9, 2.6, 3. 2, and 3. 8 in the f...

Ngày tải lên: 14/08/2014, 05:21

... Scheerder (18) 2000 Self-designed PFM-P 75 Pig coronary Ibuprofen 10 15 àg PFM-P 75 No art in 5% (g/g) Valsartan 20 25 àg PFM-P 75 No in 10% (g/g) De Scheerder (18) 2000 Self-designed PFM-P 75 Pig coronary ... Self-designed PFM-P 75 Pig coronary MP Dipcoating: PFM-P 75 Yes art 10 15 àg in 5% (g/g) 20 25 àg in 10% (g/g) Spraycoating PFM-P 75 Yes 100 150 àg in 9% (g/g) 400 450 àg...

Ngày tải lên: 14/08/2014, 05:21