Báo cáo y học: "Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data" ppt

... 2002 Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase Konstantinos Mavromatis 1, *, Iason Tsigos 2, *, Maria Tzanodaskalaki 2 , Michael Kokkinidis 1,3 and Vassilis ... the active site of the psychrophilic alkaline phosphatase from the Antarctic Table 1. Enzymatic and thermodynamic parameters of the psychrophilic...

Ngày tải lên: 22/02/2014, 04:20

... Chlamydomonas (Eur. J. Biochem. 269) 275 Isolation and characterization of a thioredoxin-dependent peroxidase from Chlamydomonas reinhardtii Aymeric Goyer 1 , Camilla Hasleka Ê s 2 , Myroslawa ... bridge. Structural and functional characteristics of Ch-PRX1 The amino-acid sequence of Ch-Prx1 shares highest identity with the BAS1 protein of Brassica, spinach, bar...

Ngày tải lên: 08/03/2014, 16:20

... m M cAMP 6202 T. Shalaby et al. (Eur. J. Biochem. 268) q FEBS 2001 The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei Tarek Shalaby, Matthias Liniger and Thomas ... Many of the structural features are well conserved between TbRSU and its mammalian counterparts. Despite this overall similarity between mammalian and trypanosomal regul...

Ngày tải lên: 31/03/2014, 23:20

... this article as: Ameratunga et al., The clinical utility of molecular diag- nostic testing for primary immune deficiency disorders: a case based review Allergy, Asthma & Clinical Immunology ... immunology@xtra.co.nz 1 Department of Clinical Immunology Auckland City Hospital, Park Rd, Grafton, Auckland New Zealand Full list of author information is avai...

Ngày tải lên: 08/08/2014, 21:20

... pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study Harald E Vonkeman 1 , Louise MA Braakman-Jansen 2 , ... using the software package S-plus (TIBCO Software Inc., Palo Alto, California, USA) professional version 6.0. Cost effectiveness To calculate the increme...

Ngày tải lên: 09/08/2014, 01:22

... [14]. Engagement of TACI on B cells results in a decreased Commentary The current status of targeting BAFF/BLyS for autoimmune diseases Meera Ramanujam and Anne Davidson Departments of Medicine and ... indicates stages of differentiation that can occur independently of BAFF. The necessity of BAFF for the survival of established memory cells or of long-lived plasm...

Ngày tải lên: 09/08/2014, 01:24

... licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases Jean-Pierre ... extent. Cathepsin K gene expression and protein synthesis The levels of both the gene expression and...

Ngày tải lên: 09/08/2014, 06:23

... in IFN- γR KO mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4 + cells to the inflamed joints. Here, we investigated whether AMD3100 ... group only a single mouse out of 8 developed symptoms 13 days after initiation of the treatment. Correspondingly, the mean arthritic group score gradually increased in controls, bu...

Ngày tải lên: 09/08/2014, 07:20

... presence of inflammatory lesions in the vicinity of apoptotic cells, as observed both in UVB-induced and in LE skin lesions in SLE patients, suggests that these lesions result from an inflammatory clearance ... cells at any Figure 3 Co-localisation of apoptotic keratinocytes and infiltrate in lupus erythematosus (LE) skin lesionsCo-localisation of...

Ngày tải lên: 09/08/2014, 08:22

... apoptosis of synoviocytes, intra-articular gene transfer could decrease the hyperplasia of the synovial intimal lining. Although not feasible for systemic administration, local therapy could debulk ... especially interesting target because it rapidly induces apoptosis in cultured synoviocytes [5]. PUMA is a Bcl-2 homology 3 (BH3)-only pro -apoptotic Bcl-2 family member recently ide...

Ngày tải lên: 09/08/2014, 08:22

... individ- uals with early radiographic changes had a greater prevalence of medial meniscal extrusion than did those with no radio- graphic changes. Any factors that affect meniscal stability and structure ... that increasing body mass index and bone size, past knee injury, and osteophytes may be causally related to meniscal extrusion. Most importantly, meniscal extrusion...

Ngày tải lên: 09/08/2014, 10:20

... properly cited. Abstract The objective of this study was to analyse levels of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) in patients with primary Sjögren's syndrome ... with increased γ-globu- Figure 1 Serum levels of macrophage migration inhibitory factor (MIF )Serum levels of macrophage migration inhibitory...

Ngày tải lên: 09/08/2014, 10:20

... standard care in the Netherlands and ANZ is substantially less than in the EGDT study. This raises serious concerns. Were the EGDT study findings the result of re-alignment of limited quality ... to address the same issue. Until the results of such trials are available, the intensivist, emergency physician and hospital administrator would do well to remain cautious abo...

Ngày tải lên: 13/08/2014, 08:21

... Post-translational modifica- tions, such as myristylation or palmitoylation, may also play critical roles in regulating membrane association. Many cytoskeleton-associated proteins interact, at least transiently, ... interface sites in this study are either intrinsically electrostatically positive (Table 3) or are located in regions that are relatively basic. Many critical biological pathway...

Ngày tải lên: 13/08/2014, 23:20

... Randomised Assessment of a Mechanical Compression Device In Cardiac Arrest (PARAMEDIC) trial is a cluster randomised pragmatic trial of the clinical and cost effectiveness of the LUCAS- 2 device ... potential participant harm as a result of delaying treatment. Conducting research in emergency situations where a patient lacks capacity is regulated...

Ngày tải lên: 13/08/2014, 23:20