Báo cáo y học: "Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury" docx

... 1667. doi:10.1186/cc8977 Cite this article as: Abraham E: Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Critical Care 2010, 14:144. Abraham Critical Care 2010, 14:144 ... 204:2439-2448. 6. Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and activated protein C signaling pathways are colocali...

Ngày tải lên: 13/08/2014, 20:21

... demonstrate for the first time that APC administered by the inhaled route may have benefit in ALI by improving gas exchange. Given the increase Commentary Inhaled activated protein C: a novel therapy ... injury (ALI). The benefits of APC therapy in sepsis are likely due to its anti-coagulant and anti-inflammatory properties, along with its roles as an anti-apoptotic fa...

Ngày tải lên: 13/08/2014, 16:20

... or too early or late in the course of their disease to have any advantageofAPC.Comparedtoarecentstudyof55 patients with acute pancreatitis (with a 30-day morta lity of 27%) [37], the patients ... Organ-failure-free days alive (ventilator-free days [22], renal replacement ther- apy-free days, va sopressor-free days), days alive outside hospital in 60 days, and changes in other labora...

Ngày tải lên: 13/08/2014, 21:21

... hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action Larry W Moreland University of Alabama at Birmingham, Birmingham, AL, USA Corresponding author: Larry W ... sources. Pathophysiology of osteoarthritis OA is characterized by a slow degradation of cartilage over several years. In normal cartilage, a delicate balance exists betwee...

Ngày tải lên: 09/08/2014, 01:21

... Care 2007, 13:126-128. 42. Saisana M, Saltelli A, Tarantola S: Uncertainty and sensitivity analysis techniques as tools for the quality assessment of composite indicators. Journal of the Royal ... missing value imputation must pro ceed via a carefully selected strategy appropriate for the data- set under analysi s. An inappropriate imputati on strategy may itself introduce bi...

Ngày tải lên: 11/08/2014, 05:21

... study. Statistical analysis The change of paw withdrawal latency (PWL) for vehicle and drug treatment groups in the Hargraeve's assay was calculated. Statistical comparisons between treatment groups ... in a kinase assay by measuring the amount of phosphorylated substrate ATF2 using a phosphoATF2 (Thr 71 ) specific primary antibody and an alkaline phosphate coupled second...

Ngày tải lên: 11/08/2014, 08:22

... guided by the clinical response, especially haemodynamic parameters: the goal should be haemodynamic stability after the withdrawal of vasoactive agents. Such rational recommen- dations have already ... not accompanied by an increase in myocardial oxygen consumption. Myocardial uptake of glucose increased significantly, whereas uptake of lactate and free fatty acids was unchanged....

Ngày tải lên: 12/08/2014, 23:23

... effector functions Clarify the importance of ADCVI activity as a means of antibody-mediated control of HIV infection; and Define the key characteristics of antibodies that induce strong ADCVI activity (e.g. isotype, ... strategy to complement traditional approaches to HIV prophylaxis and therapy. Importantly, there is increasing evidence to suggest that many arms of the inn...

Ngày tải lên: 13/08/2014, 01:20

... primer for the APOPEC3G-UBA2 fusion was 5'-ATCGTACTCGAAGCTTCTAACTCAGGAG- GAAGTTGGCAG-3'; and the 3' primer for the APOPEC3G-UBA2* fusion was 5'-ATCGTACTCGAAGCT- TCTAACTCAGagcGAAGTTGGCAG-3'. ... 5'-ATCCAAGACG- GAATTCGTTTTCCTGATTCTGGAG-3'. The UBA2 gene fragment was amplified from plasmid pcDNA3.1- HHR2 3A by PCR. The 5' primer used was 5&a...

Ngày tải lên: 13/08/2014, 05:21

... indicate that axial wall stress may considerably augment in the segment immediately proximal to the bridge entrance in the course of each cardiac cycle. Due to the variability of the many parameters ... attached to the myocardium, axial forces of hemodynamic origin cannot induce appreciable cyclic variations of its length. If the axial forces generated by the deformati...

Ngày tải lên: 13/08/2014, 16:21