protein kinases as potential targets for the treatment of pathological pain
Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx
... OA as there are currently no approved disease modifying drugs for the treatment of OA A number of protein kinases including the MAPKs have been implicated in the induction and maintenance of pain ... synoviocytes as well as prostaglandin E2 and proteinases such as the matrix metalloproteinases (MMPs) and aggrecanases [3-5] The aggrecanses and the matrix metalloproteinases are thought to mediate the ... above before the stimulation of cytokine release by the addition of LPS (1 μg/ml) The amount of TNF-α and IL-1β released was measured 18 h later by ELISA (R&D Systems, Minneapolis, MN) The viability...
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báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx
... activation of caspase-3, and in p53null myeloblastic leukemia HL-60 cells [119] It was observed that caspase-8 activity was highest after h following the treatment of TQ, while caspase-3 activity was ... p53 However, one of the enantiomers of this racemic mixture of compounds was found to possess higher affinity for the binding site as compared to others The active enantiomers of the cis-imidazoline ... inhibition of CDK It is now known that the SCF family of ubiquitinprotein ligases is responsible for protein ubiquitinylation in the G1/S phase and the related APC/cyclosome complexes perform the same...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... increasing/decreasing the replication of cells of the osteoblastic lineage or modifying the differentiated function of the osteoblast It would, therefore, be beneficial to stimulate the osteoblastic activity at ... responsible for the control of normal bone remodeling The bone morphogenetic proteins (BMPs) have bone-forming activity and account for the major proportion of the osteoinductive potential of bone ... Perhaps the most important consequence of these findings is not that the statins themselves may be effective drugs for diseases of bone loss, but rather that these results focus attention on the...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... oxidase (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the ... With the loss of biometal homeostasis placed central to all of these AD-related neurodegenerative mechanisms, the modulation of metal bio-availability has strong potential in the therapeutic treatment ... because of an imbalance in the activity of tau kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently...
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Báo cáo khoa học: Distribution of the extrinsic proteins as a potential marker for the evolution of photosynthetic oxygen-evolving photosystem II ppt
... sequencing of whole plastids and genomes of a number of photosynthetic organisms Recently, De Las Rivas et al [15] summarized the nature and composition of the extrinsic proteins of different ... PsbU proteins were detected in its nuclear genome [39] and the gene encoding the PsbV protein was found in its chloroplast genome [33] The psbV gene was also found in the chloroplast genome of other ... with the result of Shibata et al [21] The presence of PsbV in C paradoxa is consistent with the presence of the psbV gene in the complete sequences of the cyanelle genome [24], in which the psbU...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... study, the mutation of the HAS2 lysine residue 190, which is one major acceptor site for ubiquitin, led to total inactivation of its enzymatic activity The different roles of the three HAS isoforms ... breast carcinomas expressed high levels of CD44s and CD44v, as well as increased synthesis of HA [77,78] More recent studies have highlighted the importance of CD44 molecules in the onset of ... responsible for maintaining the tumor and, possibly, for the formation of new tumors at metastatic loci CD44 has been identified as an important marker of such a population of cancer stem cells in breast,...
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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf
... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic ... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... Tie2+ monocytes Therefore, Alemtuzumab is capable of killing at least a subset of Tie2+ monocytes Furthermore, CD52 expression was identified on the vast majority of ovarian tumor-associated Tie2+...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
... exhibit the feasibility of targeting host cell factors involved in infection, as they are not prone to mutations, as potential targets for siRNA therapy Henry and colleagues [85], targeted the IRES, ... protein expression due to the low expression of HCV envelops protein as well as LDLR receptor protein The siRNA combinations of siCD81 + siLDLR and siLDLR+ siSR-BI showed maximum inhibition of ... Furthermore, HCV viral load was significantly decreased up to 84% with combinations of siRNAs due to the silencing of siCD81+siLDLR gene and siLDLR+SRBI as compared to other combinations of siRNA...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... should be incapable of re-innervating the joint In this study we investigate the long-term efficacy of facet debridement for the treatment of chronic back pain originating in the facet joint MATERIALS...
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Báo cáo y học: "Endoscopic thoracic laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 case"
... internal organs as well as prominent vascular and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal ... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... (VAS) pain scores Scores were assessed at baseline and again at follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results of the...
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Behavior of Nitrite Oxidizers in the Nitrification/Denitrification Process for the Treatment of Simulated Coke-Oven Wastewater
... final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed with TE buffer ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results...
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Contact-Adsorption-Regeneration-Stabilization Process for the Treatment of Municipal Wastewater
... results of the CARS process for the municipal wastewater treatment The technical feasibility of this process was demonstrated, and the process optimization was performed In addition, the adsorption ... shown in Fig 2, the PO43 P removal increased as the HRT of the regeneration tank increased The NH4+-N removal was not very sensitive to the HRT It slightly increased as the HRT increased from h to ... illustrates the effect of HRT of the regeneration tank on the CARS system performance The COD removal increased with an increase in HRT of the regeneration tank from h to h, but decreased from h to h As...
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Designing listening tasks using authentic materials on websites as supplementary materials for the teaching of listening skills
... ready-made tasks B: Using the recordings only and designing the tasks themselves C: Assigning the recordings to the students and asking them to design the tasks themselves to share with the classmates ... lessons They also use ready-made tasks if they are suitable to their sts as they said that sometimes they not have time to modify the tasks All of them confirm that they have never assigned the recordings ... listening materials They would rather their teachers give them opportunities to design the tasks themselves Whereas, 33.5% of them want their teachers to use ready-made tasks A portion of 41% fancies...
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Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... 2.5 The most frequent site of metastatic disease is the liver In up to 50% of patients with metastatic disease, the liver may be the only site of spread For these patients surgery provides the ... to the stage of disease at diagnosis 2.2 Metastatic colorectal cancer, where the tumour has spread beyond the confines of the lymph nodes to other parts of the body, is generally defined as stage...
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Hydroxyurea for the Treatment of Sickle Cell Disease docx
... generalizability, as well as questions to assess the potential for confounding, which could bias the estimates of the treatment effect 30-32 For our assessment of the quality of the qualitative ... use of this drug for sickle cell disease Therefore, we sought information on barriers to the use of other therapies for treatment of sickle cell disease, including the receipt of routine, scheduled ... hydroxyurea treatment of hematologic diseases, the toxicity of hydroxyurea in the treatment of any disease, and the barriers to the treatment of sickle cell disease with hydroxyurea or other agents...
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Báo cáo khoa học: A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer ppt
... Cancer therapy based on Pseudomonas exotoxin A 148 Nagata S & Pastan I (2009) Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein- based therapeutics ... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... was dependent on the degradation of Mcl-1 and release of Bak [123] The anti-apoptotic protein Mcl-1 is rapidly turned over in the cell, and inhibition of its synthesis may shift the balance of...
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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc
... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... is the evidence for the optimal period of treatment and number of treatments? Duration of treatment period Parkkinen (2004) reported a mean of (3–29) weekly treatments with subjects ceasing treatment ... or the actual exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy...
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Best Practice Policy Statement on Cryosurgery for the Treatment of Localized Prostate Cancer pptx
... document based upon the peer review comments, the best practice statement was submitted to and approved by the PGC and the Board of Directors of the AUA Funding of the Panel and of the PGC was provided ... potential of thermal injury to this muscle The thermosensor is introduced through the perineal skin and advanced until the impression of the tip of the thermocouple can be seen in the sphincter The placement ... cancer has confounded the development of a national consensus regarding the optimal treatment for this disease In the American Urological Association’s (AUA) 2007 Guideline for the Management of Clinically...
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SYNTHESIZE AND INVESTIGATE THE CATALYTIC ACTIVITY OF THREE-WAY CATALYSTS BASED ON MIXED METAL OXIDES FOR THE TREATMENT OF EXHAUST GASES FROM INTERNAL COMBUSTION ENGINE
... loading of the NM is a compromise between the required efficiency of the converter and the market price of the NM However, the application of noble metals for the treatment of exhaust gas in Vietnam ... suitable for treatment of exhaust gas of diesel engine Nguyen The Tien 22 Synthesize and investigate the catalytic activity of three-way catalysts based on mixed metal oxides for the treatment of exhaust ... diameter of mm in order to form SO2 from FeS at 100 oC The velocity of the gas was 20 ml/min Meanwhile, the other was plugged in water tank that was heated up by heater with gas velocity of 440 l/h The...
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