Báo cáo y học: "A new integrative weaning index of discontinuation from mechanical ventilation" pot
Báo cáo y học: "A new integrative weaning index of discontinuation from mechanical ventilation" pot
... our study, the new integrative IWIpresented the area under the ROC curve of 0.96 and f/Vt of 0.85. Our hypothesis to justify the difference between theaccuracy of CROP index and that of IWI ... Meta-analysis under the spotlight: focusedon meta-analysis of ventilator weaning. Crit Care Med 2008,36:1-7.11. Yang KL, Tobin MJ: A prospective study of indexes predictingthe outcome of trials of ... respiratory rate; f/Vt ratio = frequency to tidal volume ratio; IWI = integrative weaning index; P 0.1 = airway occlusion pressure; PaO2/FiO2 ratio = ratio of arterial oxygen tension to fraction of...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... versions of synucleins, together w ith the A30P and A53T mutants of a-synuclein that cause f amilial c ases of Parkinson's disease.Unfortunately the quality of s ome of these syn uclein ... spectra of all theseproteins are very similar to those of disordered poly(L-glutamic acid) at high pH and poly(L-lysine) at low pH[18,19]. Accordingly, the ROA spectra of disordered poly(L-lysine) ... tructure-functionrelationships. J. Dairy Sci., in press.30. Tiany, M.L. & Krimm, S. (1968) New chain conformations of poly (glutamic acid) and polylysine. Bi opolymers 6, 1379±1382.31. Woody, R.W. (1992) Circular...
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Báo cáo Y học: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx
... SOCS-3.Peptide Kd(lM)pY343 > 30pY401 9.5 ± 0.12pY429pY431 1.1 ± 0.03F429pY431 4.6 ± 0.02pY429F431 4.9 ± 0.02 Y4 2 9Y4 31 NDpY443 NDpY461pY464 ND Y4 61pY464 NDpY46 1Y4 64 NDpY479 NDÓ FEBS 2002 ... specifically interactwith the tyrosine motifs pY401 and pY429pY431.pY429pY431 was more potently recruiting SOCS-3 thanpY401, reflecting the high affinity binding determined bySPR. The nonphosphorylated ... phosphorylatedpeptide pY429pY431 (pYpY). In comparison, the muta-tion only marginally reduces the interaction with thesingle phosphorylated peptides pY429F431 (pYF) andF429pY431 (FpY) suggesting...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... celllysates bind to a GST fusion of the cytoplasmicdomain of siglec-10. Ten micrograms of GSTalone, GST– cyto-wt and GST– cyto -Y6 67F weretyrosine phosphorylated (-P) with a mixture of Lck, ... asasthma may offer new and effective approaches toimmunomodulatory therapy. In an attempt to identify such new targets on inflammatory cells at sites of inflammation,we searched the Incyte EST database ... wild-type siglec tail by Lck and Jak3 kinases. Bycomparison, the mutation of the tyrosine at position 641 didnot significantly affect the degree of phosphorylation by any of the kinases that were...
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Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx
... Scrutton1Departments of 1Biochemistry and2Chemistry, University of Leicester, UKRecent years have witnessed high levels of activity in iden-tifying enzyme systems that catalyse H-transfer by quantumtunneling. ... increasing the catalytic efficiency of enzymes inthe biotechnology industry (by enhancing the coupling of dynamics to the reaction coordinate), and (b) producingmore effective enzyme inhibitors in ... nss4@le.ac.ukAbbreviations:TST,transitionstatetheory;TTQ,tryptophantrypto-phylquinone; MADH, methylamine dehydrogenase; AADH, aroma-tic amine dehydrogenase; TMADH, trimethylamine dehydrogenase;TSOX, heterotetrameric sarcosine dehydrogenase;...
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Báo cáo y học: : A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis" pptx
... the analysis of the S2 effect, for example, theassociation may be overestimated by the presence of S3Dcarriers in the control group (noncarrier of S2). The effect of S2 may similarly be underestimated ... effect of S2 and S3P in the analysis of S3D, the asso-ciation with negativity of anti-CCP2 remained significant.These results support the hypothesis of an associationbetween HLA-DRB1 gene polymorphisms ... study, we investigated the relevance of this new classification of HLA-DRB1 alleles in terms of RF and ACPAproduction in a cohort of French Caucasian patients with earlyRA. Interestingly, the new...
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Báo cáo y học: "A new approach to understanding the impact of circadian disruption on human health'''' pps
... phase of the light-dark cycle was reversedevery 48 hours (as if this group of rats instantly travelledback and forth from Asia to the Americas every other day).Animals were housed individually ... both nurses over the course of the seven-daymeasurement period, which indicate prolonged times of rest and, usually, darkness.Although many analyses of the activity and of the trans-formed CS ... patterns are the major synchronizer of circadian rhythms to the 24-hour solar day. Disruption of circadian rhythms has been associated with a variety of maladies.Ecological studies of human exposures...
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Báo cáo y học: " A new device to seal large coronary aneurysms: a case report" pptx
... Angiography of the right coronary artery with thepresence of a large saccular aneurysm involving the distal part of the artery to the crux cordis. (C) Partial opacification of the aneurysmal sacthrough ... 4).ConclusionsCoronary artery aneurysms may be complicated bythrombosis and rupture. The optimal treatmentoptions of coronary aneurysms are still largely debated.They include anticoagulation, ... coronary artery near the crux cordis; on the right ventricleside of the distal part of the stent, is clearly demonstrated the water density remnant of the treated aneurysm (arrows): low density fat...
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Báo cáo y học: " A new device to seal large coronary aneurysms: a case report." docx
... patient’s largest coronary vessel by1.5 to 2 times. Coronary artery aneurysms are typically diagnosed by coronary angiography. The prognosis of coronary artery aneurysm is not well known and ... 68-year-old Italian-Caucasian man presented to our hospital with angina. Coronaryangiography revealed a large coronary aneurysm of the right coronary artery, which was successfully treated bythe ... 4).ConclusionsCoronary artery aneurysms may be complicated bythrombosis and rupture. The optimal treatmentoptions of coronary aneurysms are still largely debated.They include anticoagulation,...
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Báo cáo y học: "A new approach for the large-scale generation of mature dendritic cells from adherent PBMC using roller bottle technology" ppt
... cells werematured over two days, harvested and analyzed for cell yield and mature DC phenotype by flowcytometry, and then functionally analyzed for their ability to activate allogeneic T-cell ... to adhere monocytes on toplastic in static flasks from PBMC followed by culture withGM-CSF and IL-4 and maturation using any one of anumber of cocktails of pro-inflammatory cytokines (IL-1β, ... phenotypically mature mDC from adherent monocytes using ITIP in roller bottle cultures in comparison to static flask culturesFigure 1Generation of phenotypically mature mDC from adherent monocytes...
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