Handbook of Pediatric Cardiovascular Drugs - part 10 pps

... storage of poten- tially lethal injectable drugs; 3) unit dose system of drug distribution; 4) simplifi- cation: limit the number of infusion pump types; 5) pharmacy-based admixture of all intravenous ... Gastrointestinal agents | 8. Corticosteroids | 9. Cardiovascular drugs ▼ 10. Immunoglobulins Less common Table 1 4-8 . “Top 10 types of pediatric ADRs reported Type...

Ngày tải lên: 13/08/2014, 17:22

... onset of action of approximately 1 hour and a duration of action of 12 to 24 hours. Oral absorption of the drug is dependent on the prepa- ration used, and protein binding is 95%. The half-life ... Vasodilators 109 Contraindications Phenoxybenzamine is contraindicated in patients with hy- persensitivity to the drug or any of its components. The induction of α-adren- ergic blo...

Ngày tải lên: 13/08/2014, 17:22

... Diluents Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+ )-4 -( S )-[ 1-( 2, 3-dimethylphenyl) ethyl ]-1 H- imidazole monohydrochloride. The active ingredient ... depres- sion because of its nonopioid mechanism of analgesia. Dexmedetomidine has a 1600-fold greater affinity for the α2-receptor compared with α1-receptors. 33...

Ngày tải lên: 13/08/2014, 17:22

... incidence of serious drug-drug interac- tions in pediatric patients receiving chronic antiepilepsy drugs. 12 Implications of CYP-450 Drug-Drug Interactions of Cardiovascular Drugs The CYP-450 system ... effects. 1 Protein-Binding Effects Drugs in plasma bind to proteins, including albumin, -1 -acid- glycoprotein ( -1 -AG), and lipoproteins. Albumin is the major serum prot...

Ngày tải lên: 13/08/2014, 17:22

... the age HR - Fluid restriction - Diuretics - Venous vasodilators - Arrhuthmia? - Rule out {{ JET }} - Anti-arrthythimic druge - Pacemaler - Cardioversion Preload Figure 3-4 . Treatment of acute ... duct-dependant circulation -{ { challenge }} 5-1 0 ml/kg - Repeat as needed (max 60 ml/kg) - Red Blood Cells, Fresh Frozen Plasma, albumin - R...

Ngày tải lên: 13/08/2014, 17:22

... concentrations four- to seven-fold higher than healthy patients after a single dose Pharmacokinetics Carvedilol has an onset of action of α-blockade within 30 minutes and of β-blockade of within 1 ... rates Tracheal tube: 2- to 1 0- fold times the I.V. bolus dose Adults: I.V.: loading dose of 1 to 1.5 mg/kg. May repeat doses of 0.5 to 0.75 mg/kg every 5 to 10 minutes, to...

Ngày tải lên: 13/08/2014, 17:22

... to long-term maintenance doses of 0.05 to 0.15 mg/kg/day. Some centers continue low-dose Table 8-1 . Potential combinations of immunosuppressive drugs used in pediatric thoracic transplan- tation a Number ... test of Atgam is recommended before administra- tion of the initial dose; use 0.1 mL of a 1 :100 0 dilution in NS; observe the skin test every 15 minutes for 1 hour; a...

Ngày tải lên: 13/08/2014, 17:22

... afterload. 12 Assessment and treatment of pulmonary hypertension among patients with heart disease can be life saving (Tables 1 0-1 and 1 0-2 ). Histori- cally, the incidence of true postoperative pulmonary ... the clearance of drugs in the pediatric population. Universally, the volume of distribution is increased. The magnitude of this effect depends on the size of t...

Ngày tải lên: 13/08/2014, 17:22

... packaging. Propofol is an isotonic emulsion with a pH of 7 to 8.5 and a pKa of 11. Propofol injectable emulsion is available in ready to use 20-mL, 50-mL, and 100 -mL infusion vials containing 10 mg/mL ... decrease of the induction dose as a result of a smaller central distribution and decreased clearance rate. 1 The short context-sensitive half-time of propofol, even with...

Ngày tải lên: 13/08/2014, 17:22

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Ngày tải lên: 11/08/2014, 04:21