Handbook of Pediatric Cardiovascular Drugs - part 4 ppsx
Handbook of Pediatric Cardiovascular Drugs - part 4 ppsx
... 24 hours
Hypertension: 2.5 to 5 mg/dose every 24 hours
Pharmacokinetics
Metolazone has an onset of action of approximately 1 hour and a duration of
action of 12 to 24 hours. Oral absorption of ... to 4 days
Metabolism: hepatic
Half-life: the half-life of oral phenoxybenzamine is not well known; intra-
venously, the half-life is approximately 24 hours, and effects may persis...
Handbook of Pediatric Cardiovascular Drugs - part 1 docx
... incidence of serious drug-drug interac-
tions in pediatric patients receiving chronic antiepilepsy drugs.
12
Implications of CYP -4 5 0 Drug-Drug Interactions of Cardiovascular Drugs
The CYP -4 5 0 system ... inhibition of intestinal CYP3A4 within 24 hours of ingestion
of 200 to 300 ml juice; ingestion of fresh grapefruit may decrease CYP3A4
activity by 47 % within se...
Handbook of Pediatric Cardiovascular Drugs - part 2 ppt
... Vasoconstricted
- Warm
- Vasoplegic
- Fever
Normal
CVP
- Dobutamine
- Calcium chloride
- Phenylephrine
- Vasopressin
- Dopamine
- Dobutamine
Low
CVP
Filling
Myocardial dysfunction
Norepinephrine
Figure 3-3 . ... albumin
- Rule out hemorrhage
- Arrhythmia?
- Pacemaker
- Atropine
- Isoprenaline
Optimal
Normal
for the age
HR
- Fluid r...
Handbook of Pediatric Cardiovascular Drugs - part 5 pdf
... concentrations four- to seven-fold higher than healthy patients after
a single dose
Pharmacokinetics
Carvedilol has an onset of action of α-blockade within 30 minutes and of
β-blockade of within 1 ... effectiveness of meto-
prolol in adolescent hypertension. Pediatr Pharmacol (New York) 2(1): 49 –55.
4. Torp-Pedersen C, Poole-Wilson P, et al. (2005). Effects of metoprolol and...
Handbook of Pediatric Cardiovascular Drugs - part 6 docx
... to long-term
maintenance doses of 0.05 to 0.15 mg/kg/day. Some centers continue low-dose
Table 8-1 . Potential combinations of immunosuppressive drugs used in pediatric thoracic transplan-
tation
a
Number ... first-pass effect.
Verapamil has a half-life in infants of 4 to 7 hours, and, in adults, of 4
to 12 hours. Verapamil is eliminated in the urine.
7. Antiarrhythmic...
Handbook of Pediatric Cardiovascular Drugs - part 7 pot
... circuit (Mulla, 2003a
44
; Mulla, 2003b
45
).
Propofol
Propofol is highly lipophilic and protein bound. Propofol levels can fall to 45 %
of their expected level after the initiation of cardiopulmonary ... 1996;
270:H9 74 H980.
40 . Rimar S, Gillis CN. Site of pulmonary vasodilation by inhaled nitric oxide in the per-
fused lung. Journal of Applied Physiology 1995; 78(5):1 745 –...
Handbook of Pediatric Cardiovascular Drugs - part 8 pdf
... Chan AK, Massicotte MP. The use of low-molecular-weight heparin in
pediatric patients: A prospective cohort study. J Pediatr 2000; 136: 43 9 44 5.
18. Schmidt B, Ofosu FA, Mitchell L, Brooker LA, ... decrease of the
induction dose as a result of a smaller central distribution and
decreased clearance rate.
1
The short context-sensitive half-time of
propofol, even with prolonged...
Handbook of Pediatric Cardiovascular Drugs - part 9 pps
... Diluents
Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and
is chemically described as (+ ) -4 -( S )-[ 1-( 2, 3-dimethylphenyl) ethyl ]-1 H-
imidazole monohydrochloride. The active ingredient ... depres-
sion because of its nonopioid mechanism of analgesia. Dexmedetomidine has
a 1600-fold greater affinity for the α2-receptor compared with α1-receptors.
33...
Handbook of Pediatric Cardiovascular Drugs - part 10 pps
... 230
advantages/disadvantages of, 228
dosage of, 232–233
mechanism of action and, 231–232
toxicity of, 233–2 34
vasodilators compared with, 235–237
Inotropic drugs
digoxin, 35–39
dobutamine, 40 41
dopamine, 41 44
dopexamine, ... drug
Adrenaline. See Epinephrine
α-adrenergic agonists/blocking
agents, 43
Adrenergic agonist agents
dobutamine, 40 41
dopamine, 41 44
norepinephrin...
Handbook of Lubrication Episode 1 Part 4 ppsx
... x′and y′satisfies the right-hand sides of Equations
47 and 48 :
(49 )
(50)
where:
Equations 49 and 50 give the forced vibration response solution to Equations 47 and 48
as distinct from the natural ... equation for s is
(43 )
where solutions are
(44 )
Referring to Equation 42 we see that our two natural frequencies are
(45 )
which are the natural frequencies of two simple, unco...