Báo cáo y học: "Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients" pps
Báo cáo y học: "Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients" pps
... triggers inflam-matory cascades involving as many as 14 distinct signalingpathways, including the NF-κB pathway. Interestingly, many of the genes in these pathways are regulated by the proteasome ... [8].ViewpointTargeting the ubiquitin proteasome pathway for the treatment of septic shock in patientsJan Brun1,2,3and Douglas A Gray1,21Ottawa Health Research Institute, Ottawa, ON, Canada K 1Y ... K48Rmutant ubiquitin interferes more strongly with NF-κBsignaling. Therefore, the proteasome is likely a better target for anti-NF-κB intervention than the IKK cascade for treatment of septic shock. ...
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Báo cáo y học: "A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder" pot
... ± 5.9, indicating amoderate severity of depression. The subjects missed anaverage of 10 hours of work in the past 2 weeks owing totheir symptoms, which represented 16% of the time theywere ... productivity subscalescores.Figure 1 shows the degree of clinical impairment (definedas percentage of the sample scoring 2 or higher on the item, indicating 50% or more of the time) in the individ-ual ... VariablesTable 1 shows the demographic and clinical information for the 234 subjects studied. The profile is typical of amood disorders cohort attending a specialty clinic. The mean score on the QIDS-SR...
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Báo cáo y học: " BODE index versus GOLD classification for explaining anxious and depressive symptoms in patients with COPD " pptx
... scoring.Variables and point values used for the computation of the BODE index are shown in table 1. Finally after obtain-ing the BODE index for all patients, quartiles of the BODEindex were used to ... classification for explaining these symptoms. Anxious symptoms wereexplained by dyspnoea. Depressive symptoms wereexplained by both dyspnoea and reduced exercise capac-ity.COPD is increasingly considered ... only of the lungs. It has been suggested as a part of the 'chronicsystemic inflammatory syndrome' together with the met-abolic syndrome, coronary artery disease and others [32].The...
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Báo cáo y học: "S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review" ppt
... analysis.Conclusions In such circumstances, the findings of the presentstudy should aid future investigators in examining the clinicalusefulness of these markers and determination of cut-off values.IntroductionIdentifying ... the process of aggravation of brain injury, while brain imaging, physical examination, andelectrophysiology all focus on the consequences of braininjury. NSE is a protein located in nerve cells ... verybeginning of brain injury the secretion and release of S100B(and hence elevation of serum S100B levels, if any) might notnecessarily be indicative of aggravation of brain injury; it maybe indicative...
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Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc
... 2002understanding of the function and organization of the enzyme complex, the analysis of mutant a lleles of the ge nesinvolved in the biosynthetic pathway c an certainly providevaluable information. In ... addition of Tween 40 [39], i t can be concluded that the 482 Gly residue is important for the activity of the enzyme, likely being one of the residues m ediating substratebinding. In strain C5, ... been described for bothZygomycetes. In Phycomyces they complement neither the carR nor the carA mutants, and i n Mucor they complementneither the carP nor the carR mutants. They are white, l...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... otypic analysis (at the p rotein level), the f ewanimals yielding in their milk the as1-CasM variant wereexclusively heterozygous M/F a t the as1-Cas locus. There-fore, analysis o f their ... secondly impairs the phosphorylation of Ser64 in the M variant. The sequence determined is consistent with the molecular massmeasured for the native protein. The phosphorylatedresidues a re therefore ... 3 in the 9thexon of the A alle le, which is deleted in the F allele, ismutatedtoTintheMallele, giving rise to a Ser fi Leusubstitution.Analysis of the intronic flanking sequences The flanking...
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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
... elusive.Relevance of the findings The question of whether our findings are of any significance for the understanding of CIJD is justified and needsanswering.1. Involving microbial infections as a leading ... cells in pathogen-induced chronic inflammatory joint diseases. Any inflammation will cause the induction of chemokine and cytokine production in several tissue-associated cells in the joint, including ... TLR-2engagement therefore influences the differentiation of Tcells not only by the activation of DCs (indirect pathway Figure 2Direct co-stimulation of cytotoxic T lymphocyte (CTL) lines via Toll-like...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf
... phase of inflammatory arthritis [27,28]. Since the pro-apoptotic pro-tein Bid links the extrinsic to the intrinsic pathway, we exam-ined the affect of inducing experimental inflammatory arthritis in ... & Therapy Vol 9 No 3 Scatizzi et al.Page 4 of 10(page number not for citation purposes)invasion of leukocytes, proliferation of synoviocytes resulting in the thickening of the synovial lining, ... Bid is a crucial interme-diary for the apoptotic pathways in the development of inflam-matory arthritis.Competing interests The authors declare that they have no competing interests.Authors'...
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Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps
... was involved in the analysis of data from this study and interpretation and presentation of results. RY was involved in the interpretation of the data, anddrafting of this article. IO was involved ... adherence to newly-initiated ULDswas common in gout patients, with only 44% of the study pop-ulation achieving an MPR > 0.80 in the first year of therapy.Predictors of non-adherence included age ... to ULD initiation, we looked separately at dis-pensings of NSAIDs, colchicine and glucocorticoids in the 30days prior to and including the date of the first ULD dispens-ing.Analyses The characteristics...
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Báo cáo y học: " Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder" pps
... Germany.2Interdisciplinary Centre for Clinical Trials (IZKS), UniversityMedical Centre, Mainz, Germany.3Clinic for Psychiatry and Psychotherapy,Katzenelnbogen, Germany.4Clinic for Psychiatry ... discussion of the results.Psychologists of the in the participating trial sites weretrained in the application of the neuropsychologicaltests. At the beginning, all raters had to execute the testby ... immuno-inflammatory system with the aetiology and the pathophysiology of MDD.Recently, a larger panel of pro- a nd anti-inflammatorycytokines was measured in a case/control population of MDD showing...
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