Báo cáo y học: " In silico analysis of chimeric espA, eae and tir fragments of Escherichia coli O157:H7 for oral immunogenic applications" doc

... tertiary structure of the chimeric protein, EspA-Intimin -Tir. The result was viewed by Rasmol soft- ware. Analysis of chimeric EspA-Intimin -Tir protein secondary structureFigure 3 Analysis of chimeric ... secre- tion proteins) for vaccination of healthy cattle as an aid in reducing shedding of Escherichia coli O157: H [44]. Both of these vaccines are high ris...

Ngày tải lên: 13/08/2014, 16:20

... the C-terminal part contains a redox cofactor binding site for either pyrroloquinoline quinone (PQQ) or NADPH. In particular, AASDH, containing a PQQ binding domain, is supposed to be involved in lysine degradation ... following abbreviations. Aa: L-a-aminoadipate; Orn: L-ornithine; DHPG: 3,5-hydroxy-L-phenylglycine; PGly: L-phenylglycine; b-A: b-alanine; Aas: L-a-aminoadipate semialdeh...

Ngày tải lên: 23/03/2014, 13:20

... frequency events could be mea ning- fully quantified, including the evolution of randomly mutated strains occurring in the absence of gene ther- apy and ii) consistency of results. As a validation of ... largely due to a pool of replicating wild-type HIV that is maintained in non-gene containing CD4+ T cells. Th is wild-type HIV effectively out-competes emerging viral strains,...

Ngày tải lên: 13/08/2014, 01:20

... platform for in- silico screening of potential INSTIs. Docking of integrase strand transfer inhibitors (INSTIs) reveals unexpected metal-binding modes The docking poses of five well known INSTIs, ... residues, Y1 43 and E148 To generate a surrogate platform for predicting docking of INSTIs, a model of HIV-1 IN in complex with both puta- Mapping of the nucleic acid-bi...

Ngày tải lên: 13/08/2014, 09:20

... similar to peptidylprolyl isomerase A isoform 1; inversin isoform a; inversin isoform b; 9890 bp at 5' end: hypothetical protein LOC158405; 17561 bp at 3' end: hypothetical protein LOC58493; ... contributions BW and WM conceived of the study, conducted the in silco analyses and contributed to drafting the final manuscript. BW, WM and KH participated in data analysis a...

Ngày tải lên: 13/08/2014, 16:20

... effects of variations in serine and glycine inputs, and the effects of methionine and protein loading. Conclusion: The model reproduces many experimental findings and gives new insights into the underlying ... does the system accommodate changes in the input of serine and glycine? What happens during protein or methionine loading? What are the roles of folate-binding pro...

Ngày tải lên: 13/08/2014, 16:21

... is involved in a variety of inflammatory and tissue repair processes, the question of how it affects the apoptotic response of potential target cells is of major interest. In the present study ... FasL induced apopto- sis. Our findings point to yet unconsidered effects of mod- ulating proinflammatory cytokines that must be taken into account when novel biological agents such a...

Ngày tải lên: 09/08/2014, 01:23

... McPoil for his contribution to analysis and interpretation of data; the University of Queensland Graduate School for funding a Research Travel Grant for MF; and Bob Buckley for designing a software ... tape induced reductions in activation of TP and MG. It is plausible that in redu- cing activity of TP and MG, tape may assist the resolu- tion of symptoms and...

Ngày tải lên: 10/08/2014, 21:24

... panel). AsshowninFig.4,N-amidino-2-hydroxypyrrolidine inhibits competitively t he NOS-I and NOS-II catalyzed conversion of L -arginine to L -citrulline and the trypsin catalyzed hydrolysis of N-a-benzoyl- L -arginine ... building of the NOS-II: and trypsin: N -amidino-2-hydroxypyrrolidine complexes Molecular models of the human NOS-II: and bovine trypsin:N-amidino-2-hydroxypyr...

Ngày tải lên: 17/03/2014, 23:20

... strain analysis of the global and regional myocardial function for the differentiation of pathologic and physiologic left ventricular hypertrophy: A study in athletes and in patients with hyper- trophic ... of the peak systolic longitudinal strain between segments with LE ≥ 51% and LE 1-50% 15 . By using the previously proposed cut-off value 15 for strain of...

Ngày tải lên: 25/10/2012, 11:15