... inhibitory activity accordingly increases, whichleads to low expression levels of genes involved in ER+ cell types and the predominant expression of genes involved in the oncogenic pathways ... *Program in Computational Biology and Bioinformatics, Yale University, George Street, New Haven, CT 06511, USA. †State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life ... respec-tively, and all of them show higher inhibitory effects in ER-breast cancer. In the WA (Wang et al. [40]) dataset, we iden-tified 377 RE-changing miRNAs, of which 373 have higherinhibitory effects...