Báo cáo y học: " Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance" pot

... enzymes containing different family and s ubfamily members and isoenzymes within each of them [1]. The most clinically relevant isoforms for pharmacogenomic practice are CYP 2D6, CYP 2C9, and CYP 2C19. ... 8:12 http://www.clinicalproteomicsjournal.com/content/8/1/12 Page 2 of 9 REVIEW Open Access Drug metabolizing enzyme activities versus genetic variances for drug...

Ngày tải lên: 13/08/2014, 13:20

... proportionally less often. Regarding the severity of abuse or dependence (our can- nabispatientsusedthisdrugonaverageon62%ofthe days of a month; Deas et al. [28] reported only half as many drugs for their ... study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. BMJ 2005, 330:11. 20. Semple DM, McIntosh AM, Lawrie SM: Cannabis as a risk factor...

Ngày tải lên: 13/08/2014, 18:21

... malignancy. Maximal exercise capacity was determined by incremental cycle ergometry [1]. The University of California, San Diego, shortness of breath questionnaire (UCSD SOBQ) was used to quantify dysp- nea, ... Services, and the Agency for Healthcare Research and Qual- ity. The study sponsors of the NETT Genetics Ancillary Study had no role in study design, data collection, analysis...

Ngày tải lên: 12/08/2014, 15:21

... to form Ang II, ACE2 hydrolyzes a single amino acid from the carboxyl end of Ang II to form Ang-(1–7) [2]. ACE is considered the primary enzymatic pathway that catalyzes the generation of ... the enzymatic activity.  e current study reveals a potentially novel mechanism to attenuate the catalytic activity of ACE2, thereby promoting the infl ammatory actions of Ang II. ACE and A...

Ngày tải lên: 12/08/2014, 14:22

... phosphorylated peptide pY429pY431 (pYpY). In comparison, the muta- tion only marginally reduces the interaction with the single phosphorylated peptides pY429F431 (pYF) and F429pY431 (FpY) suggesting ... 1). SOCS-3 needs a double phosphorylated Y4 2 9Y4 31 motif for highest affinity binding The motif pY429pY431 of the EpoR contains two tyrosine phosphorylation sites, spaced only by one ami...

Ngày tải lên: 24/03/2014, 00:21

... in hyperplasia of the synovial tissue, and the activated synovial cells produce inflammatory cytokines and degradative enzymes. These pathological processes in RA synoviocytes are tightly regulated ... participated in the experimental design of the study. AM performed statistical analyses and partici- pated in the design of the study. YT conceived of the study, participated in its des...

Ngày tải lên: 09/08/2014, 06:22

... Vollmar 1 1 Department of Experimental Surgery, University of Rostock, Rostock, Germany 2 Department of Trauma & Reconstructive Surgery, University of Rostock, Rostock, Germany 3 Institute of Immunology, University ... The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis. Best Pract Res Cl...

Ngày tải lên: 09/08/2014, 06:23

... innate immunity is also involved in early BD and interacts with adaptive immunity, as reflected by the presence of perforin, presumably secreted by CD3 + T cells. It might therefore be of interest ... readily influence observations in inflammatory cells. On the other hand, those micro-organisms are also capable of stimulating an immune response in BD. Most tissue studies of the pathop...

Ngày tải lên: 09/08/2014, 14:20

... volitional control of the nerve transfer, although they evaluated their patients for an average period of only 3 years, which may be a short interval for cortical integration of the hypoglossal to ... atrophy and the platysma muscle remained functional. Results 8 years after surgeryFigure 5 Results 8 years after surgery. The accessory nerve was con- nected to the suprascapular nerve...

Ngày tải lên: 10/08/2014, 09:22

... mediastinitis is a critical complication of cardiovas- cular surgery and may easily be caused by mid-line sternotomy. Therefore, the choice of operative approach plays an important role in preventing ... mediastinitis. Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying Figure 1 Postoperative photograph of wound on...

Ngày tải lên: 10/08/2014, 09:22