Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx

... 1 of 12 (page number not for citation purposes) Comparative Hepatology Open Access Research TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate ... conse- quence of the aerobic lifestyle caused by the photosyn- thetic activity of herbal organisms, which in turn depends on the capability of oxygen reduction occ...

Ngày tải lên: 13/08/2014, 13:20

... it may, the ability of PtdEtn-PLD to bind to immobilized PtdEtn may facilitate the future use of a PtdEtn-affinity matrix for purification of PtdEtn-PLD by phospholipid-affinity chromatography. In ... regardless of whether the yeast cultures are initiated in YPD, YPG or YPA. Interestingly, further analysis has shown that PtdEtn-PLD activity is also stimulated upon exit of yeast ce...

Ngày tải lên: 22/02/2014, 07:20

... type [14,18,28]. It has already been observed by several authors that secretion of a number of cytokines was at least partly restored by DHEA treatment [14,18,21,22,28]. Our results are partly ... normalizes mRNA cytokine levels time dependently, with regard to the immunologic tissue context. As initially mentioned, pro- and anti-inflammatory cytokines influence the expression levels o...

Ngày tải lên: 13/08/2014, 18:22

... capability of monocytes and macrophages to phagocytose invading pathogens [16]. GM-CSF treatment of septic patients’ lymphocytes ex vivo has been shown to restore function in anergic monocytes ... in plasma and synovial fluid in hyperinflammatory states [9] and in vitro experiments have shown that the inflammatory cytokine IFN-γ induced shedding of HLA-DR by human monocytes [10]...

Ngày tải lên: 03/11/2012, 09:57

... previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 in COS7 cells and in primary human mesenchymal progenitor cells. The results reported by Milling- ton-Ward ... can be used to silence predominately one allele of COL1A2 in primary bone cells. The next step is to scan the full range of polymorphisms in the COL1A2 and COL1A1 and to des...

Ngày tải lên: 03/11/2012, 11:52

... 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By using a very ... Uni- versity of Rome-Tor Vergata, Italy), was elicited against the conserved FAAH sequence VGYYETDNYTMPSPAMR [26]. Isolation of human monocytes and differentiation into dendritic cell...

Ngày tải lên: 22/02/2014, 07:20

... Ca 2+ -stimulated autophosphory- lation of CCaMK results in time -dependent loss of enzyme activity. This time -dependent loss of activity or self-inacti- vation due to autophosphorylation is also dependent ... chimeric calcium/calmodulin -dependent protein kinase P. V. Sathyanarayanan and B. W. Poovaiah 1 Laboratory of Plant Molecular Biology and Physiology, Department of Ho...

Ngày tải lên: 17/03/2014, 17:20

... reversible inhibitors of cholinesterases. However, at concentrations around 10 m M , they have been found to activate the hydrolysis of positively charged substrates, catalyzed by wild-type human butyrylcholinesterase ... curve analysis of BTC hydrolysis by recombinant wild-type human BuChE, by four selected mutants (Y3 32A/D70G, Y3 32D/D7 0Y, W82A, A32 8Y) and by commercial horse s...

Ngày tải lên: 24/03/2014, 03:21

... fact that not all cells in the synovial lining will be targeted. By optimizing this, we might be able to target every single one of the synovial lining cells and thereby fully block the TGF-β-induced ... cartilage of the OA model. TGFβ-induced synovial fibrosis was strongly diminished by simultaneous synovial overexpression of Smad7 in the synovial lining. Of great interest, ove...

Ngày tải lên: 09/08/2014, 07:20

... mononuclear cells was approximately 1:10. Flow cytometry The purity of PMN was routinely analyzed by flow cytometry with FACSCalibur (BD Biosciences, Heidelberg, Germany). In brief, to prevent ... Man- nheim, Germany) and labeled by use of the Dyomics DY-648- S-NHS/DY-548-S-NHS dye system (Dyomics, Jena, Ger- many). Dyomics DY-648-S-NHS-labeled cDNA was cohybrid- ized with DY-548-S-NH...

Ngày tải lên: 09/08/2014, 10:21