Handbook of Experimental Pharmacology - Part 5 ppsx

Handbook of Experimental Pharmacology - Part 5 ppsx

Handbook of Experimental Pharmacology - Part 5 ppsx

... potassium current IKs by (R )-2 -( 2,4-trifluoromethyl)-N-[2-oxo- 5- phenyl- 1-( 2,2,2-trifluoroethyl )-2 , 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. J Med Chem 40:38 65 3868 Sesti F, Tai KK, Goldstein ... determinants of dofetilide block of HERG K+ channels. Circ Res 82:386–3 95 Ficker E, Jaro limek W, Brown AM (2001) Molecular determinants of inactivation and dofetil...
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Handbook of sexual dysfunction - part 5 ppsx

Handbook of sexual dysfunction - part 5 ppsx

... clitoris. Journal of Anatomy 1998; 159 :1892–1897. 25. Grafenberg E. The role of the urethra in female orgasm. International Journal of Sexology 1 950 ; 3:1 45 148. 26. Levin RJ. The mechanisms of human female ... result of absence of sexual stimu- lation or of lack of knowledge about, bad technique of, a lack of attention for, or negative emotions to sexual stimuli—explai...
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Handbook of Experimental Pharmacology - Part 1 pps

Handbook of Experimental Pharmacology - Part 1 pps

... Tables ISSN 017 1-2 004 ISBN-10 3 -5 4 0-2 496 7-2 Springer Berlin Heidelberg New York ISBN-13 97 8-3 -5 4 0-2 496 7-2 Springer Berlin Heidelberg New York Library of Congress Control Number: 20 059 254 72 This work ... 201 Shiroshita-Takeshita, A. 2 35 Sipido, K.R. 159 Tsuji, Y. 2 35 Varro, A. 159 Viswanathan, P.C. 331 Wehrens, X.H.T. 123 Zicha, S. 2 35 HistoryofArrhythmia...
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Handbook of Experimental Pharmacology - Part 1 docx

Handbook of Experimental Pharmacology - Part 1 docx

... New method for terminating cardiac arrhyth- mias. Use of synchronized capacitor discharge. JAMA 182 :54 8 55 5 Lüderitz B (19 95) History of the disorders of cardiac rhythm, second edn. Futura Publishing Company, ... MolecularDescription 54 3.3 Regional Distribution of HCN Isoforms and MiRP1 55 3.4 Approaches for Region-Specific Modification of I f 56 4RoleofI f in Generating C...
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Handbook of Experimental Pharmacology - Part 3 pdf

Handbook of Experimental Pharmacology - Part 3 pdf

... DM (1999) Inhibition of P-glyco- protein-mediated drug transport: a unifying mechanism to explain the interaction be- tween digoxin and quinidine. Circulation 99 :55 2 55 7 Hoffmeyer S, B urkO, von ... (2004) Voltage-dependent gating of hyperpolarization- activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers. J Biol Chem 279:13 859 –138...
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Handbook of Experimental Pharmacology - Part 4 doc

Handbook of Experimental Pharmacology - Part 4 doc

... actions of antiarrh ythmic drugs. Am J Cardiol 59 :E10–E18 Rosen MR, Hoffman BF, Wit AL (19 75) Electrophysiology and pharmacology of cardiac- arrhythmias. 5. Cardiac antiarrhythmic effects of lidocaine. ... that form part of the contact points with inner mouth blockers are present (Fig. 2a). The lack of the P-X-P sequence in the S6 domain of KCNH2 creates a large volume of...
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Handbook of Experimental Pharmacology - Part 6 pdf

Handbook of Experimental Pharmacology - Part 6 pdf

... Na (+) -Ca(2+) exchangers by 7- chloro-3 , 5- dihydro -5 - phenyl-1H-4,1-benzothiazepine-2-one (CGP-37 157 ). J Pharmacol Exp Ther 306:1 050 –1 057 Paulus WJ, Goethals MA, Sys SU (1992) Failure of myocardial inactivation: ... inhibition of Na + /Ca 2+ exchange by SN-6 [ 2-[ 4- (4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzy- loxyphenyl derivati...
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Handbook of Experimental Pharmacology - Part 7 pot

Handbook of Experimental Pharmacology - Part 7 pot

... (1990) KN-62, 1-[ N,O-bis ( 5- isoquinolinesulfonyl)-N-methyl-L-tyrosyl ]-4 -phenylpiperazine, a specific inhibitor of Ca 2+ /calmodulin-dependent protein kinase II. J Biol Chem 2 65: 43 15 4320 Toyofuku ... Arrhythmia Treated by β-Blockers 250 5. 1 Prophylactic U se of β-Blockers in Myocardial Infarction . 251 5. 2 Prophylactic U se of β-BlockersinCongestiveHeartFailure 251 5. 3...
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Handbook of Experimental Pharmacology - Part 8 pdf

Handbook of Experimental Pharmacology - Part 8 pdf

... amiodaro ne, which has non-competitive β-antagonist properties, does not replace β-blockers, and it underlines the significance of the use of β-blockers. 5. 2 Prophylactic Use of β-Blockers in Congestive ... of β-blockers in CHF is the prevention of sud- den arrhythmic death (Cleophas and Zwinderman 2001). Such benefits may be due to the prevention of proarrhythmic effects of β-a...
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Handbook of Experimental Pharmacology - Part 9 doc

Handbook of Experimental Pharmacology - Part 9 doc

... (2002) Increased risk of arrh ythmic events in long-QT syndrome wi th mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation 1 05: 794–799 Motoike HK, ... 171:287–304 © Springer-Verlag Berlin Heidelberg 2006 Mutation-Specific Pharmacology of the Long QT Syndrome R.S. Kass 1 (✉)·A.J.Moss 2 1 Department of Pharmacology, Columbia Uni versit...
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