Báo cáo y học: " Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation" docx

... nonseptic origin. Low levels of protein C in acute lung injury are associated with poor clinical outcome. The present article discusses the beneficial effects of rhAPC in oleic acid-induced lung injury ... [13], since smoke inhalation and sepsis are major contributors to mortality in burn patients [14]. The Commentary Recombinant human activated protein C...

Ngày tải lên: 13/08/2014, 11:23

... Norway 5 Department of Medical Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway 6 Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, ... protein C (APC), which is catalyzed by the action of thrombin/thrombomodulin complex when protein C is bound to its endothelial receptor (endothelial...

Ngày tải lên: 13/08/2014, 11:22

... G: Recom- binant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of pro- tease -activated ... anesthesiology of Univer- sity Hospital of North Norway and the Institute of Clinical Med- icine of the University of Tromsø (Tromsø, Norway), and in part by Eli L...

Ngày tải lên: 13/08/2014, 11:23

... al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Critical Care 2010 14:R217. Submit your next manuscript ... Recombinant human activated protein C in experimental models of acute lung injury: the timing is critical! Intensive Care Med 2007, 33:2048-2050. 21. Mayb...

Ngày tải lên: 14/08/2014, 07:21

... frequent in obese patients with insulin resistance. These findings show that in young adults the only abdominal adiposity without insulin resistance, plays a scarce role in determining hepatic steatosis ... and Functional Sciences, Federico II University Medical School of Naples, Italy and 3 Department of Neurosciences, Unit of Clinical Pharmacology, Federico II University M...

Ngày tải lên: 11/08/2014, 08:22

... by precipitating the C4 b-binding protein- bound fraction with polyethylene glycol 8000 and measuring the con- centration of free protein S in the supernatant. Free protein S deficiency was defined ... human activated protein C resets thrombin generation within the first 8 h of infusion. • The administration of recombinant activated protein C does not...

Ngày tải lên: 12/08/2014, 22:22

... in the course of the disease can be challenging because most insults causing lung injury are not predictably timed. ANOVA: analysis of variance; ALI: acute lung injury; APACHE II: acute physiology ... persistently elevated alveolar endostatin levels during the early course of the disease. Our models of the early onset of lung injury suggest these changes occur...

Ngày tải lên: 13/08/2014, 16:20

... Griffin JH: Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C. ... enoxaparin has not been investigated in this model. Therewerenosignsofasystemicprofibrinolytic effect of enoxaparin, or the combination of enoxaparin with DAA....

Ngày tải lên: 14/08/2014, 07:21

... usually is neglected and excluded in clinical trials but is omnipresent in real life. Based on the data in this study, the presence or absence of any comorbidity has an impact on the occurrence of ... inform the analysis. In contrast to stratification, this is an effective way to incorporate observations on all patients in the analysis. The dichotomy between in...

Ngày tải lên: 09/08/2014, 14:20

... did achieve the lower dose regime. Increasing the intensity of therapy beyond the ‘new high dose’ may not confer additional clinical benefit. Finally, a study on cessation of therapy. A further ... subgroup analysis of the BEST kidney data (Beginning and Ending Supportive Therapy for the Kidney) has examined the clinical parameters associated with successful cessation of c...

Ngày tải lên: 13/08/2014, 20:21