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Báo cáo y học: " Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation" docx

Báo cáo y học:

Báo cáo y học: " Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation" docx

... nonseptic origin. Low levels of protein C in acute lung injury are associated with poor clinicaloutcome. The present article discusses the beneficial effects of rhAPC in oleic acid-induced lung injury ... [13], since smoke inhalation and sepsisare major contributors to mortality in burn patients [14]. The Commentary Recombinant human activated protein C in acute lung injury: what is the role of bronchial ... activated protein C (rhAPC) in oleic acid-inducednonseptic acute lung injury (ALI) in sheep [1].Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Treatment...
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Báo cáo y học:

Báo cáo y học: "Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep" doc

... Norway5Department of Medical Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway6Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, ... protein C (APC), which is catalyzed by the action of thrombin/thrombomodulin complex when protein C is boundto its endothelial receptor (endothelial cell protein C receptor).Acting together ... ovineendotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human activated protein C (rhAPC),with its anticoagulant, anti-inflammatory, fibrinolytic andantiapoptotic effects,...
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Báo cáo y học:

Báo cáo y học: "Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep" pdf

... G: Recom-binant human activated protein C upregulatescyclooxygenase-2 expression in endothelial cells via bindingto endothelial cell protein C receptor and activation of pro-tease -activated ... anesthesiology of Univer-sity Hospital of North Norway and the Institute of Clinical Med-icine of the University of Tromsø (Tromsø, Norway), and in partby Eli Lilly and Company (Indianapolis, IN, USA). ... sheep subjected to intravenous bolus injection of oleic acid (OA) and co-administration of recombinant human activated protein C (rhAPC). In the figure, OA refers to the oleic acid-alone group...
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Báo cáo y học:

Báo cáo y học: "Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock" ppt

... al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Critical Care 2010 14:R217.Submit your next manuscript ... Recombinant human activated protein C in experimental models of acute lung injury: the timing is critical! Intensive Care Med 2007, 33:2048-2050.21. Maybauer MO, Traber DL, Maybauer DM: Recombinant human activated protein ... glycocalyx. It is obviousthat lipopoly saccharide-induced major microcirculationdysfunction accompanied by microvascular oxidativestress and glycocalyx degradation may be limited byAPC. This...
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Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx

... frequent in obese patients with insulinresistance. These findings show that in young adults the only abdominal adiposity without insulin resistance, plays a scarce role in determining hepatic steatosis ... and Functional Sciences, Federico II University Medical School of Naples, Italy and 3Department of Neurosciences, Unit of Clinical Pharmacology, Federico II University Medical School of Naples, ... UniversityMedical Center trying to clarify some correlations betweenIR and NAFLD, liver disease almost characteristic of youngobese patients [15].Protocol was consistent with the principles of the...
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Báo cáo khoa học: "Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study" pot

... by precipitating the C4 b-binding protein- boundfraction with polyethylene glycol 8000 and measuring the con-centration of free protein S in the supernatant. Free protein Sdeficiency was defined ... human activated protein C resets thrombin generation within the first 8 h of infusion.• The administration of recombinant activated protein C does not influence parameters of fibrinolysis and inflam-mation.Open ... activation [2]. Thrombin mayalso affect the production of inflammatory cytokines by bindingto protease -activated receptors (PARs) in mononuclear cells[3]. Secondly, rhAPC may inhibit the action...
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Báo cáo y học: " Type XVIII collagen degradation products in acute lung injury" pot

... in the course of the disease can be challenging because mostinsults causing lung injury are not predictably timed.ANOVA: analysis of variance; ALI: acute lung injury; APACHE II: acute physiology ... persistently elevated alveolar endostatinlevels during the early course of the disease. Our models of the early onset of lung injury suggest these changes occurvery early in the injurious process. ... influencing nearly12% of the genome via a variety of mechanisms [39]. Clearly in order to firmly establish the pathophysiological importance of endostatin release in the development of lung injury...
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Báo cáo y học: "Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism." ppt

... Griffin JH: Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulantmechanism of heparin, enhancement of inactivation of factor V by activated protein C. ... enoxaparin has not beeninvestigated in this model.Therewerenosignsofasystemicprofibrinolyticeffect of enoxaparin, or the combination of enoxaparinwith DAA. The lack of a profibrinolytic effect of ... of factorVIIIa reduces the acti vity of the tenase complex and the production of factor Xa. Inactivation of factor Vareduces the activity of the prothrombinase complex and the production of thrombin....
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Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx

... usually is neglected andexcluded in clinical trials but is omnipresent in real life. Basedon the data in this study, the presence or absence of anycomorbidity has an impact on the occurrence of ... inform the analysis. In contrast to stratification, this is an effective way toincorporate observations on all patients in the analysis. The dichotomy between ineffectiveness and toxicity as aphysician-reported ... usimportant insights into daily-life use of TNF inhibitors in PsA, adisease that too often is secondary to RA in the scientific andclinical perceptions of rheumatologists. The authors dealeffectively...
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Báo cáo y học: " Recently published papers: Renal support in acute kidney injury is low dose the new high dose" doc

... did achieve the lowerdose regime. Increasing the intensity of therapy beyond the ‘new high dose’ may not confer additional clinical benefit.Finally, a study on cessation of therapy. A further ... subgroupanalysis of the BEST kidney data (Beginning and EndingSupportive Therapy for the Kidney) has examined the clinicalparameters associated with successful cessation of continuous RRT [9]. This ... balances of just20 ml being achieved. This is a unique study in that allpatients received only continuous therapies and the studytherapy was discontinued in dialysis-dependent patientswhen they...
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