recombinant human activated protein c rhapc

... pool plasma The levels of free protein S are expressed as a percentage of total protein S Data represent mean ± SD rhAPC, recombinant human activated protein C Fig 2, protein C levels normalized ... Levels of protein C and protein C inhibitor Plasma levels of (a) protein inhibitor C and (b) protein C inhibitor in the rhAPC group (▲) and the control group (❍) The levels of protein C and protein ... F1+2 rhAPC group (▲) and the control group (❍) Data represent mean ± SD F1+2, prothrombin fragment F1+2; rhAPC, recombinant human activated protein C; TAT, thrombin-antithrombin complexes rhAPC...

Ngày tải lên: 12/08/2014, 22:22

... controlled trials: the case of recombinant human activated protein C Br Med J 2001, 323:923-926 Machala W, Wachowicz N, Komorowska A, Gasynski W: The use of drotrecogin alfa (activated) in severe sepsis ... A, Steingrab JS, Garber GE, Welterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Padkin A, Rowan K, Black ... Characterization and novel purification of recombinant human protein C from three mammalian cell lines Biotechnology (NY) 1990, 8:655-661 Esmon CT: Protein C anticoagulant pathway and its role...

Ngày tải lên: 12/08/2014, 22:22

... safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344: 699-709 Kanji S, Perreault MM, Chant C, Williamson D, Burry L: Evaluating the use of Drotrecogin alfa (activated) ... 33:517-523 Bertolini G, Rossi C, Anghileri A, Livigni S, Addis A, Poole D: Use of drotrecogin alfa (activated) in Italian intensive care units Intensive Care Med 2007, 33:426-434 Page of (page number...

Ngày tải lên: 13/08/2014, 08:21

... Jamal HH, Johnson G III, Bernard GR, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group: Recombinant Human Activated Protein C Worldwide Evaluation in ... population Given that randomization of APC was not possible after publication of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study, our goal was to develop ... APC, activated protein C; PCS, physical component score; SF-36, 36-item Short Form Figure SF-36 role physical scores during the follow-up period (age-adjusted) (age-adjusted) APC, activated protein...

Ngày tải lên: 13/08/2014, 10:20

... depletion of protein C and APC in septic states Investigators reported recently that infusion of recombinant human activated protein C (rhAPC) enhances the plasma concentration of protein C and ... as the mean ± standard error of the mean rhAPC, recombinant human activated protein C alone (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC- treated LPS group (n = 9); PVRI, pulmonary ... filtration in awake, endotoxemic sheep rhAPC, recombinant human activated protein C alone sheep group (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC- treated LPS group (n = 9) Data...

Ngày tải lên: 13/08/2014, 11:22

... (OA) and co-administration of recombinant human activated protein C (rhAPC) In the figure, OA refers to the oleic acid-alone group (n = 8), OA +rhAPC refers to the rhAPC- treated OA group (n = 8), ... and co-administration of recombinant human activated protein C (rhAPC) In the figure, OA refers to the oleic acid-alone group (n = 8), OA +rhAPC refers to the rhAPC- treated OA group (n = 8), and ... acid (n = 8), and OA +rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8) aP < 0.05 from t = hours bP < 0.05 between OA and the OA +rhAPC groups AaPO2, alveolar-arterial...

Ngày tải lên: 13/08/2014, 11:23

... JD, Ely EW, Fisher CJ Jr; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein C for severe sepsis ... LJ: Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep Crit Care 2008, 12:R104 Wang Z, Su F, Rogiers P, Vincent JL: Beneficial effects of recombinant human ... protein C for severe sepsis N Engl J Med 2001, 344:699-709 Levi M, van der Poll T: Recombinant human activated protein C: current insights into its mechanism of action Crit Care 2007, 11(Suppl...

Ngày tải lên: 13/08/2014, 11:23

... Bjertnaes LJ: Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep Crit Care 2008, 12:R104 12 Waerhaug K, Kirov MY, Kuzkov VV, Kuklin VN, Bjertnaes LJ: Recombinant ... lipopolysaccharide (n = 8); LPS+inhAPC = sheep receiving LPS and inhaled nebulised recombinant human activated protein C (n = 8); PaCO2 = arterial carbon dioxide partial pressure; pH = arterial ... lipopolysaccharide group (n = 8); LPS+inhAPC = LPS group treated with aerosolised inhaled recombinant human activated protein C (n = 8); Sham = sham-operated group (n = 8) * P < 0.05 between LPS and LPS+inhAPC...

Ngày tải lên: 13/08/2014, 16:20

... alfa (activated) in human endotoxemia Shock 2004, 21:222-229 Derhaschnig U, Reiter R, Knobl P, Baumgartner M, Keen P, Jilma B: Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated] ) ... nM/ml/mg protein) Data expressed as mean ± standard error of the mean of seven animals per group Significance P < 0.05: †versus sham; *versus control rhAPC, recombinant human activated protein ... ± 14.7# 167.3 ± 26.7#† rhAPC 100 ± 78.1 ± 6.0 81.8 ± 9.1* 104.4 ± 15.5* Regional microvascular blood flow (percentage from baseline) rhAPC, recombinant human activated protein C P ≤0.05: #vs...

Ngày tải lên: 14/08/2014, 07:21

Ngày tải lên: 13/08/2014, 11:23

... A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Dellinger RP, Carlet JM, ... received rhAPC had significantly higher 28-day mortality rates (20.7% versus 14.1%, p = 0.03, n = 635) [4] Should this ADDRESS post hoc subset analysis also influence our prescribing of rhAPC as ... of death in the PROWESS trial, the effect of rhAPC in these patients would have been enhanced So the key to patient selection for administration of rhAPC might be a priori assessment of risk of...

Ngày tải lên: 12/08/2014, 23:21

... of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344: 699-709 Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW: Gene expression profile of antithrombotic protein ... KR, Fouty BW, O’Brien J, Gruber M, Zarini S, Murphy RC, Kuhn K, et al.: Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil ... effects of activated protein C in septic shock patients Intensive Care Med 2005, 31:1573-1576 Wiel E, Costecalde ME, Lebuffe G, Corseaux D, Jude B, Bordet R, Tavernier B, Vallet B: Activated protein...

Ngày tải lên: 13/08/2014, 03:20

... showed low PC levels and high endogenous activated protein C (APC) to PC ratios [6] Exogenous recombinant human activated protein C (drotrecogin alpha activated) has been shown to significantly ... JD, Ely EW, Fisher CJ Jr, Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein C for severe sepsis ... improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis Arch Surg 2006, 141:670-676 Chen P, Zhang Y, Qiao M, Yuan Y: Activated protein C, an anticoagulant...

Ngày tải lên: 13/08/2014, 21:21

... Xa, a-thrombin, protein S, human activated protein C and prothrombin were purchased from Kordia Laboratory Supplies (Leiden, the Netherlands) All coagulation factors were of human origin unless ... from Pall Gelman Laboratory (Ann Arbor, MI, USA) Expression and purification of recombinant human protein C Recombinant protein C variants K37S/K38Q/K39Q (37-loop mutant), K62N/K63D (60-loop mutant), ... of factor Va and factor VaR506Q by activated protein J Biol Chem 270, 21158–21166 11 Nicolaes, G.A.F & Dahlback, B (2003) Congenital and acquired ă activated protein C resistance Sem Vasc Med...

Ngày tải lên: 19/02/2014, 13:20

... immunomodulatory agents previously tested clinically, recombinant human APC was found to be significantly beneficial in the PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) ... Wright TJ: Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis ... Claessens YE: Protein C /activated protein C pathway: overview of clinical trial results in severe sepsis Crit Care Med 2004, 32(Suppl):S194-S201 Lyseng-Williamson KA, Perry CM: Drotrecogin alfa (activated) ...

Ngày tải lên: 12/08/2014, 22:21

Ngày tải lên: 12/08/2014, 22:21

... Cases Controls P value Lowest activated protein C level (%) 85 (76–102) 97 (73–136) 0.009 Lowest protein C level (%) 52 (8–70) 70 (18–113) 0.03 Lowest activated protein C /protein C ratio 1.1 (0.87–13.2) ... Griffin JH: Direct detection of activated protein C in blood from human subjects Blood 1992, 79:2340-2348 Petaja J, Hakala L, Rasi V, Griffin JH: Circulating activated protein C in subjects with heterozygous ... LopezRodriguez A, Steingrub J, Garber G, Helterbrand J, Ely W, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Lasson A, Ohlsson K: Consumptive...

Ngày tải lên: 12/08/2014, 23:21

... sepsis vary markedly in their ability to generate activated protein C Blood 2004, 104:3958-3964 Fernandez JA, Petaja J, Gruber A, Griffin JH: Activated protein C correlates inversely with thrombin ... value of protein C concentrations in neutropenic patients at high risk of severe septic complications Crit Care Med 2000, 28:22092216 Gruber A, Griffin JH: Direct detection of activated protein ... R, Fernandez JA, Griffin JH, Repo H, Petaja J: Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe pancreatitis Crit...

Ngày tải lên: 12/08/2014, 23:21

... mechanism of activated protein C action during endotoxemia Crit Care Med 2004, 32:1011-1017 Jackson CV, Bailey BD, Shetler TJ: Pharmacological profile of recombinant human activated protein C (LY203638) ... and procoagulant state Crit Care Med 2000, 28:3672-3678 Abraham E: Effects of recombinant human activated protein C in human models of endotoxin administration Proc Am Thorac Soc 2005, 2:243-7 Wiel ... hemodynamic effects of activated protein C in septic shock patients Intensive Care Med 2005, 31:1573-1576 Bhattacharya A, Grinnell BW, Cohen ML: Unlike thrombin, protein C and activated protein C not...

Ngày tải lên: 12/08/2014, 23:22

Ngày tải lên: 13/08/2014, 01:20