... andRichardODay*1,2COMMENTARY*Correspondence: r.day@unsw.edu.au2Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital, Sydney, NSW, 2010, AustraliaFull list of author information is ... of urate, or ‘under-excretion’, accounts for up to 90% of hyperuricaemia cases. In the remainder, the mechanism is excessive production of urate due to purine synthetic enzymatic abnormalities, ... al.: A proposal for identifying the low renal uric acid clearance phenotype. Arthritis Research & Therapy 2010, 12:149.Indraratna et al. Arthritis Research & Therapy 2010, 12:149 http://arthritis-research.com/content/12/6/149Page...