BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... is characterized by three compact domain-like regions (one at either end and one in the middle), separated by two extended stretches (Figure 9 .7) . The N-terminal region of the a-andb-fibrinogen chains are rich ... common a-subunit and a unique b-subunit. The b-subunit shows less homology to that of other members of the group. It consists of 118 amino acids, is particularly rich in cystei...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... therapeutic 8 BIOPHARMACEUTICALS Interleukin-1 (IL-1) 232 The biological activities of IL-1 233 IL-1 biotechnology 234 Interleukin-3: biochemistry and biotechnology 235 Interleukin-4 236 Interleukin-6 238 Interleukin-11 ... 273 Thrombopoietin 273 Further reading 275 Chapter 7 Growth factors 277 Growth factors an d wound healing 277 Insulin-like growth factors (IGFs) 279 IGF...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... manufacturing and control section 4 Sampling, methods of validation, package and labelling 5 Non-clinical pharmacology and toxicology data 6 Human pharmacokinetics and bioavailability data 7 Microbiology ... antibiotic to be discovered, and was found effective against Gram- negative and Gram-positive bacteria, rickettsias and chlamydias. It retains activity when administered or...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... Sciences, Ireland The media constituents, several of which are heat-labile, are generally dissolved in WFI and filter-sterilized into the pre-sterile animal cell reactor. Reactor design (and operation) ... Follicle-stimulating hormone (FSH) CHO Insulin E. coli Interferon-b CHO Erythropoietin CHO Interferon-a E. coli Glucocerebrosidase CHO Interferon-g E. coli Factor VIIa BHK Interleukin-2 (...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein Molecular mass (kDa) IFN-a 20– 27 TNF-a 52* EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20–25 G-CSF 21 Insulin 5 .7 IL-2 15–20 EPO 36 hGH 22 IL-1 17. 5 TPO 60 FSH 34 IL-12 30–35 IGF-1 7. 6 LH 28.5 *Biologically ... receptor superfamily Receptors for IL-2 7, -9 , -1 2, G-CSF, GM-CSF, EPO, LIF, CNTF, GH The Interferon receptor superfamily Cytokine receptor type II family Receptors fo...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells. Its growth and differentiation-inducing effects ... factors (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL-1, IL-6, IL-10, IL-12 Eosinophils IL-3, IL-5 Vascular endothe...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... IGF-1 is a 70 amino acid polypeptide displaying three intra-chain disulphide linkages and a molecular mass of 7. 6 kDa. IGF-2 ( 67 amino acids; 7. 5 kDa) also has three disulphide linkages. IGF-1 and ... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 284 BIOPHARMACEUTICALS IGF bioc...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... for details a-Galactosidase and urate oxidase Recombinant a-galactosidase and urate oxidase represent two additional biopharmaceuticals recently approved for general medical use. a-Galactosidase ... preparations, however, are only partially purified and modern preparations are generally subjected to additional high-resolution chromatographic fractiona- tion (Figure 10.1). Ion-exchange...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of single-stranded RNA (ssRNA) of approximately 5–8 kb. Upon entry into sensitive cells, the viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse- quently integrates ... 477 Figure 11 .7. Structure of some cationic lipids and polylysine Additional viruses that may prove of some use as future viral vectors include adeno- associated virus and he...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... factors 2 57 8 IL-1 232–5 IL-1a 232–3 IL-1Ra 234 IL-1b 232–3 IL-2 224, 225–32 IL-3 235–6, 2 57 8 IL-4 224, 236–8 IL-5 241–3 IL-6 238–40 IL-10 224 IL-11 240–1 IL-12 244–6 IL-13 224 IL-18 224 International ... effects 203 7 biotechnology 2 07 10 IFN-a 122, 196, 1 97 8, 210–13, 520–6 IFN-b 122, 196, 1 97, 198, 213–14 IFN-g 196, 1 97, 198, 214–16, 278 IFN-g 1B 216 IFN-o 219 IFN-t 219 JAK–STAT...
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