BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... is
characterized by three compact domain-like regions (one at either end and one in the middle),
separated by two extended stretches (Figure 9 .7) .
The N-terminal region of the a-andb-fibrinogen chains are rich ... common
a-subunit and a unique b-subunit. The b-subunit shows less homology to that of other members
of the group. It consists of 118 amino acids, is particularly rich in cystei...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... therapeutic
8 BIOPHARMACEUTICALS
Interleukin-1 (IL-1) 232
The biological activities of IL-1 233
IL-1 biotechnology 234
Interleukin-3: biochemistry and biotechnology 235
Interleukin-4 236
Interleukin-6 238
Interleukin-11 ... 273
Thrombopoietin 273
Further reading 275
Chapter 7 Growth factors 277
Growth factors an d wound healing 277
Insulin-like growth factors (IGFs) 279
IGF...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... manufacturing and control section
4 Sampling, methods of validation, package and labelling
5 Non-clinical pharmacology and toxicology data
6 Human pharmacokinetics and bioavailability data
7 Microbiology ... antibiotic to be discovered, and was found effective against Gram-
negative and Gram-positive bacteria, rickettsias and chlamydias. It retains activity when
administered or...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... Sciences,
Ireland
The media constituents, several of which are heat-labile, are generally dissolved in WFI and
filter-sterilized into the pre-sterile animal cell reactor. Reactor design (and operation) ... Follicle-stimulating hormone (FSH) CHO
Insulin E. coli Interferon-b CHO
Erythropoietin CHO
Interferon-a E. coli Glucocerebrosidase CHO
Interferon-g E. coli Factor VIIa BHK
Interleukin-2 (...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein
Molecular
mass (kDa)
IFN-a 20– 27 TNF-a 52* EGF 6
IFN-b 20 GM-CSF 22 NGF 26
IFN-g 20–25 G-CSF 21 Insulin 5 .7
IL-2 15–20 EPO 36 hGH 22
IL-1 17. 5 TPO 60 FSH 34
IL-12 30–35 IGF-1 7. 6 LH 28.5
*Biologically ... receptor
superfamily
Receptors for IL-2 7, -9 , -1 2, G-CSF,
GM-CSF, EPO, LIF, CNTF, GH
The Interferon receptor
superfamily
Cytokine receptor type II
family
Receptors fo...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co-
stimulatory roles in the maturation of the range of blood cells.
Its growth and differentiation-inducing effects ... factors (CSFs) and platelet-derived growth factor (PDGF)
Cell type Interleukins produced
Macrophages IL-1, IL-6, IL-10, IL-12
Eosinophils IL-3, IL-5
Vascular endothe...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... IGF-1 is a 70 amino acid polypeptide displaying three intra-chain disulphide linkages and
a molecular mass of 7. 6 kDa. IGF-2 ( 67 amino acids; 7. 5 kDa) also has three disulphide
linkages.
IGF-1 and ... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes
increased expression of FSH and LH receptors in ovarian tissue.
284 BIOPHARMACEUTICALS
IGF bioc...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... for details
a-Galactosidase and urate oxidase
Recombinant a-galactosidase and urate oxidase represent two additional biopharmaceuticals
recently approved for general medical use. a-Galactosidase ... preparations, however, are only partially purified and modern
preparations are generally subjected to additional high-resolution chromatographic fractiona-
tion (Figure 10.1). Ion-exchange...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of
single-stranded RNA (ssRNA) of approximately 5–8 kb. Upon entry into sensitive cells, the
viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse-
quently integrates ... 477
Figure 11 .7. Structure of some cationic lipids and polylysine
Additional viruses that may prove of some use as future viral vectors include adeno-
associated virus and he...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... factors 2 57 8
IL-1 232–5
IL-1a 232–3
IL-1Ra 234
IL-1b 232–3
IL-2 224, 225–32
IL-3 235–6, 2 57 8
IL-4 224, 236–8
IL-5 241–3
IL-6 238–40
IL-10 224
IL-11 240–1
IL-12 244–6
IL-13 224
IL-18 224
International ... effects 203 7
biotechnology 2 07 10
IFN-a 122, 196, 1 97 8, 210–13, 520–6
IFN-b 122, 196, 1 97, 198, 213–14
IFN-g 196, 1 97, 198, 214–16, 278
IFN-g 1B 216
IFN-o 219
IFN-t 219
JAK–STAT...