BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx

... activities of IL -1 233 IL -1 biotechnology 234 Interleukin-3: biochemistry and biotechnology 235 Interleukin-4 236 Interleukin-6 238 Interleukin -1 1 240 Interleukin-5 2 41 Interleukin -1 2 244 Tumour ... processing and packaging instructions 11 0 Records 11 1 Generation of manufacturing records 11 1 Sources of biopharmaceuticals 11 2 E. coli as a source of recombinant, th...

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... pharmacokinetics and bioavailability data 7 Microbiology data 8 Clinical data 9 Safety update reports 10 Statistical section 11 Case report tabulations 12 Case report forms 13 and 14 Patent information and ... Topics Curr. Chem. 18 8, 12 7 19 5. McManus, M. (19 97). Mechanisms of bacterial resistance to anti-microbial agents. Am. J. Health Syst. Pharm. 54 (12 ), 14 20 14 33. Mar...

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... overnight. NaOH is particularly effective at removing most contaminant types 0.5–2.0 M NaCl Non-ionic detergents (0 .1 1. 0%) NaOH (0 .1 1. 0 M) Acetic acid (20–50%) Ethanol ($20%) EDTA ( $1. 0 mM) Protease ... starting and packaging materials 9 Manufacture of liquids, creams and ointments 10 Manufacture of pressurized metered dose aerosol preparations for inhalation 11 Computerized sys...

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... (FGFs) Platelet-derived growth factor (PDGF) Insulin-like growth factors 1 and 2 (IGFs 1 and 2) Transforming growth factor b1 (TGF-b1) Granulocyte-macrophage colony-stimulating factor (GM-CSF) Erythropoietin ... increased androgen and oestradiol synthes is by these cells. IGF -1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 284 BIOPHARMACEUTICALS...

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... medicine and the future — new vaccine development. Br. Med. J. 324(7349), 13 15 13 19. Russo, S. et al. (19 97). What’s going on in vaccine technology? Med. Res. Rev. 17 (3), 277–3 01. Sandhu, J. (19 94). ... vaccine adjuvants. Pharmaceut. Res. 19 (6), 715 –728. Strominger, J. (19 95). Peptide vaccination against cancer? Nature Med. 1( 11) , 11 40. Wang, R. & Rosenberg, S. (19 99)...

Ngày tải lên: 13/08/2014, 07:20

... Protein Molecular mass (kDa) IFN-a 20–27 TNF-a 52* EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20–25 G-CSF 21 Insulin 5.7 IL-2 15 –20 EPO 36 hGH 22 IL -1 17.5 TPO 60 FSH 34 IL -1 2 30–35 IGF -1 7.6 LH 28.5 *Biologically ... receptor superfamily Receptors for IL-2–7, -9 , -1 2, G-CSF, GM-CSF, EPO, LIF, CNTF, GH The Interferon receptor superfamily Cytokine receptor type II family Receptors f...

Ngày tải lên: 13/08/2014, 07:20

... factors (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL -1 , IL-6, IL -1 0 , IL -1 2 Eosinophils IL-3, IL-5 Vascular endothelial cells IL -1 , IL-6, IL-8 Fibroblasts ... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells...

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... consists of two a-chains (14 1 amino acids) and two b-chains (14 6 amino acids), with each subunit displaying an associated haem prosthetic group. The interaction of the oxygen-binding haem moiety and the ... Gastroenterology 12 2(2), 5 31 544. Goa, L. et al. (19 97). Lisinopril — a review of its pharmacology and use in the management of the complications of diabetes mellitus. Drugs 53...

Ngày tải lên: 13/08/2014, 07:20

... therapeutics. Blood Rev. 10 (4), 2 01 209. Fitzgerald, G. (19 96). The human pharmacology of thrombin inhibition. Coronary Artery Dis. 7 (12 ), 911 – 918 . Markwardt, F. (19 91) . Hirudin and its derivatives ... stroke. Saudi Med. J. 23 (1) , 13 19 . Blasi, F. (19 99). The urokinase receptor. A cell surface, regulated chemokine. APMIS 10 7 (1) , 96 10 1. Castillo, P. et al. (19 97). Cost...

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... 207 10 IFN-a 12 2, 19 6, 19 7–8, 210 13 , 520–6 IFN-b 12 2, 19 6, 19 7, 19 8, 213 14 IFN-g 19 6, 19 7, 19 8, 214 16 , 278 IFN-g 1B 216 IFN-o 219 IFN-t 219 JAK–STAT pathway 202–3 PEGylated 211 receptors 19 9 signal ... 278 approved biopharmaceuticals 11 , 502–3 haemopoietic growth factors 257–8 IL -1 232–5 IL-1a 232–3 IL-1Ra 234 IL-1b 232–3 IL-2 224, 225–32 IL-3 235–6, 257...

Ngày tải lên: 13/08/2014, 07:20