Báo cáo y học: "Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression" ppsx

... previously that IκBα can translocate to the nucleus in T lymphocytes activated with phorbol-12- myristate-13-acetate (PMA) [7], but little is known about the existence of a NF-κB/IκBα shuttling in resting ... activation. The nuclear accumulation of IκBα in resting CD 4 + T lymphocytes results in inhibition of HIV -LTR dependent transcription as well as restrains...

Ngày tải lên: 13/08/2014, 05:22

... copy of the written consent is available for review by the Editor -in- Chief of this journal. Competing interests The authors declare that they have no competing interests. Authors’ contributions All ... patient was referred to the outpatient clinic of the Department of Endocrinology, at the University Hospital of Crete, for examination of her parathyroid function. Discussion Vari...

Ngày tải lên: 11/08/2014, 14:20

... present study, we demonstrated that chemically modi- fied AddnIκB-PEG-RGD exhibited a shift in specificity of cell entry from its intrinsic CAR-driven entry pathway to an αv integrin-mediated pathway. ... An interesting observation was the fact that the amount of transgene protein required to inhibit NF-κB dependent gene transcription was much less than the amount of endogenous IκB...

Ngày tải lên: 09/08/2014, 07:20

... the Pycnogenol extract are procyanidins that consist of catechin and epicatechin sub- units of varying chain lengths [1]. The quality of this extract is specified in the United States Pharmacopeia (USP ... monocytes were incubated with plasma obtained after 5 days Pycnogenol intake. The plasma of all study five participants exhibited an inhibi- tory effect on LPS-induced NF-κB activ...

Ngày tải lên: 11/08/2014, 08:21

... pathways leading to a pro-apoptotic effect. These findings suggest that low concentration of ethanol shifts the balance into the apoptotic direction after its initial effect on protein kinases. ... after its initial effect on protein kinases phosphorylation. The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly...

Ngày tải lên: 31/10/2012, 15:37

... signal-recognition particle (SRP). Furthermore, in vitro cross-linking experiments revealed that the G-10L mutant protein is routed to the SecYEG translocon via the SRP pathway, the targeting pathway that ... protein, like that of the wild-type precursor, was strongly impaired in comparison with the processing in the wild-type strain (Fig. 2B). Apparently, substitution of the glycin...

Ngày tải lên: 08/03/2014, 09:20

... 1053 results suggest that PTP-1B could negatively regu late insulin signaling by acting on t wo different componen ts of the pathway. A plethora of s tudies demonstrate that PTP-1B can attenuate insulin ... intracellular hydrogen peroxide that is thought to reversibly oxidize an d t hus inactivate the invariant cysteine in the catalytic domain of PTP-1B [97]. In another study, i...

Ngày tải lên: 17/03/2014, 23:20

... activity of PpTGase might be similar to that by which they inhibit the enzymatic activity of TGase 4. Hydrolysing activity of GTP was also found in the purified PpTGase protein as in the case of TGase ... Biology, Faculty of Textile, Kyoto Institute of Technology, Kyoto, Japan Transglutaminase (TGase) catalyses the post-translational modification of proteins by transamidation...

Ngày tải lên: 17/03/2014, 23:20

... and immunocytochemistry indicated that the lateral oviduct cells of the reproductive tracts produce IEP-1/ IEP-2 mRNAs and secrete the proteins into the oviduct. These data suggest that the expression ... approximately one day after the initiation of the capsid protein expression in the pupal stage (Fig. 4). These data suggest that characteristics of IEPs are a typical for PDV structu...

Ngày tải lên: 31/03/2014, 15:20

... reversal line indicated by deeply-stained hematoxylin structure with osteoclasts and osteoblasts. This finding suggests that bone formation occurred over a long period of time. In conclusion, ... cells took place in the metaplasia of the true-stromal undifferentiated cells. There are two theories in the origin of the bone-forming cells osteoblast and osteocytes: one from...

Ngày tải lên: 08/08/2014, 16:23