Báo cáo y học: " Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant" doc

... exposed to solvent and is packed between the basic region and the cysteine-rich region. Results Synthesis and biological activity of Tat Eli The chemical synthesis of Tat Eli was performed in ... compared the trans-activational activity of this synthetic Tat Eli with both a synthetic subtype B Tat (HXB2(86)) and with a recombinant subtype B Tat. We show th...

Ngày tải lên: 13/08/2014, 05:21

... m M for glycerol. The enzyme required the adenosylcobalamin coenzyme for catalytic activity and the K m for the cofactor was 8 l M . Inactivation of the enzyme was observed by both glycerol and cyano- cobalamin. ... affinity for the cofactor. The K m obtained was similar to that obtained for the enzyme of L. brevis (7 l M ) [20]. The study of the effect of dif...

Ngày tải lên: 23/03/2014, 21:20

... walk Availability for the duration of the entire study period Exclusion History of underlying inflammatory arthropathy or severe rheumatoid arthritis Hyperuricaemia (>440 μmol/l) and/ or past history of ... properties by inhibiting the 5-lipoxygenase enzyme. A 90-day, double-blind, randomized, placebo-controlled study was conducted to evaluate the efficacy and safety...

Ngày tải lên: 09/08/2014, 10:23

... by the Editor-in-Chief of this journal. Acknowledgements The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Defense or other ... displayed cytologic atypia (Figure 3), but none of the latter showed morphologic transitions with the MLT areas. All areas of the lesion displayed myo-epi- thelial c...

Ngày tải lên: 11/08/2014, 23:21

... out and analysed all the experi- ments and contributed to writing the manuscript. P.H. conceived of the study, participated in the study design, performed the statistical analysis and drafted the manuscript. All ... included in one of the incuba- tion mixtures in case of an enzyme-catalyzed hydrolysis of the 17α furoate moiety or of the 17β S-fluoromethyl-...

Ngày tải lên: 12/08/2014, 15:21

... design the study, performed detailed phylogenetic analysis of the sequences, and helped write the manuscript. SHQ and HJ together obtained the full-length genome of HTLV-4, ana- lyzed the sequences, ... predates the inferred origin of the ancestors of HTLV-1, HTLV-2, and HTLV-3 by about 76,000 – 191,000 ya [31]. Two equally parsimonious hypotheses on the origin...

Ngày tải lên: 13/08/2014, 05:21

... the design of the study and QY performed the statistical anal- ysis. LJC and QY participated in the final figure prepara- tion and drafted the manuscript. All authors read and approved the final ... evaluate the relevance of the NFκB trans-acting factor, we silenced the expression of NFκB in TE26 using lentiviral siRNA targeting the p50 of the NFκB dime...

Ngày tải lên: 13/08/2014, 09:20

... in the airways as the mucociliary elevator would remove all pathogens re- siding within mucus layer of the airways´ lining fluid. As this elevator is driven by the beating of the cilia, their ... and mortality in the majority of CF patients (1). This pathogen colonises the airways and lungs often in the late teens or early twenties and can be controlled for a p...

Ngày tải lên: 03/11/2012, 11:48

... puri®ed and the gene encoding the enzyme has been cloned and sequenced. The enzyme was rapidly and irre- versibly inactivated by sodium borohydride o r h ydroxyl- amine in the presence of propionyl-CoA. ... (DSMZ, Braunsc hweig, Germany). Synthesis of acyl-CoA substrates Acetyl-, butyryl- and propionyl-CoA were prepared from the corresponding anhyd rides and CoA by th...

Ngày tải lên: 17/03/2014, 17:20

... addition to the groups of eating disorders and co- morbidity of major depression and dysthymia, patients with the diagnosis of dysthymia (P < 0.05), and patients with the comorbidity of major ... Firstly, the control group was not randomly selected, and its size was small in comparison to the patient population. Furthermore, they were not the primary focus of...

Ngày tải lên: 08/08/2014, 20:23