Báo cáo khoa học: "Airway closure: the silent killer of peripheral airways" docx

... closing of peripheral airways with tidal ventilation at low lung volumes. Such stresses will be enhanced in the presence of increased Commentary Airway closure: the silent killer of peripheral ... alterations are the consequence of abnormal stresses that develop locally at the level of both the bronchiolar epithelium and the parenchyma, mainly at alveolar- bron...

Ngày tải lên: 13/08/2014, 03:20

... is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study are shown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... panose (data not shown). Prediction of the positions of amino acid residues whose substitutions resulted in the reduction of the IPU activity While the study...

Ngày tải lên: 19/02/2014, 16:20

... we find: (i) Examination of 50% of the data in the SLs leads to identification of between 75% (AdjN) and 80% (PNV) of the TPs. (ii) For the first 40% of the SLs, and lead to the worst results, with ... fre- quency) and the weak measures ( and ). In the second half of the data in the SLs, how- ever, there is virtually no difference between , , and the other measu...

Ngày tải lên: 20/02/2014, 18:20

... direct exploitation of the structural results of the former to explain the mechanism of CaM activation of the latter. Crystallization and resolution of the 3D structures of AC and AC–CaM, which ... respectively, the values of the center and the normalized amplitude of each lifetime peak. c I i are the values of the partial intensity of the i th compon...

Ngày tải lên: 07/03/2014, 15:20

... ion mode CID-TOF ⁄ TOF MS analysis of the same precursor yielded the corresponding signature peaks (m ⁄ z 1404.88, 1438.82 and 1470.80) of the other part of the disulfide bond, i.e. the negatively ... making them the active antimicrobial compounds of the bacitracin mix. The oxidation of the amino-thiazoline ring to the keto-thiazole ring to form bacitracin H and F...

Ngày tải lên: 14/03/2014, 23:20

... region. The association of WASP and the Arp2 ⁄ 3 complex activates the actin nucleation activity of the Arp2 ⁄ 3 complex [23]. To investigate further the function of the WASP- EVH1 domain in the ... 5B). Therefore, the EVH1 domain of WASP is not func- tional, at least in the Ag receptor-induced proliferative response of B cells. T cells from the other three 21SHL...

Ngày tải lên: 16/03/2014, 14:20

... how the second kinase in the cascade determines the time dependence of the activity of the third kinase, we varied the V max of the second kinase reaction and recalculated the concentration of the ... of signaling are controlled by the kinases or phosphatases in the system, and whether they are controlled differ- entially by some or all of them. On the basi...

Ngày tải lên: 16/03/2014, 18:20

... clustering but on understanding the expression of intent. 3 Method We address the main thesis of the work by retrospec- tively studying queries issued to a search engine over the course of 12 consecutive months. Q-queries. ... higher 7 An explanation of why the upward trend starts at the end of 2007 is beyond the scope of this work; we postulate that this coincides w...

Ngày tải lên: 17/03/2014, 00:20

... changes of the pro- tomer resulting in a displacement of the cofactor bound at the active site by 2.6 A ˚ (mean distance) in the direction of the iron and Glu286 which causes a loss of the stabilizing hydrogen ... complex, the binding of the cofactor at the active site results in the formation of stabilizing hydrogen bonds between the dihydroxypropyl side-cha...

Ngày tải lên: 17/03/2014, 09:20

... prop- erties of individual dimensions of the antecedent and consequent pairs, but also properties of their combinations (e.g., the product of the first dimen- sions of the antecedent and the consequent). ... a total of 1246 AN sequences, such as big cat, that occur more than 100 times in the corpus. These AN sequences encompass 190 of the 256 adjec- 26 Proceedings...

Ngày tải lên: 17/03/2014, 22:20