Báo cáo khoa học: "Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis" pptx

... [7]. The conversion of protein C to activated protein C is impaired during sepsis, and reduced Commentary Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis Saurabh ... drotrecogin alfa (recombinant human activated protein C) [5]. Drotrecogin alfa (Xigris; Eli Lilly, Indianapolis, IN, USA) is a 55 kDa glycoprotein a...

Ngày tải lên: 12/08/2014, 22:22

... 2 Research Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep Kristine Waerhaug 1 , Vsevolod V Kuzkov 1 , Vladimir N Kuklin 1 , ... Waerhaug K, Kuklin VN, Kirov MY, Sovershaev MA, Langbakk B, Ingebretsen OC, Ytrehus K, Bjertnaes LJ: Recombinant human activated protein C attenuates endotoxin-induced lung inj...

Ngày tải lên: 13/08/2014, 16:20

Ngày tải lên: 12/08/2014, 22:21

... In the present issue of Critical Care, Pettila and colleagues report the fi rst single-centred pilot randomized controlled trial of activated protein C (APC) in alcohol- induced acute ... pancreatic tissue, resulting in multiple organ failure. This dysregulated in ammation leading to organ dysfunction also characterizes severe sepsis. Activated protein C (APC) has pleot...

Ngày tải lên: 13/08/2014, 21:21

... small intestine. MGA contains five distinct protein domains: a small cytosolic domain (26 amino acids) a transmembrane domain (20 amino acids), an O-glycosylated linker (or stalk) (55 amino acids), ... may be important in stabilizing active site interactions, the ring size also affects binding in the enzyme active site. The fact that salacinol, contain- ing a five-membered ring, has pro...

Ngày tải lên: 07/03/2014, 12:20

... have been evaluated in large clinical trials, only recombinant human activated protein C (drotrecogin alfa (activated) (DrotAA; Xigris ® ); Eli Lilly and Company, Indianapolis, IN, USA] has been ... DM: Human recombinant activated protein C in meningococcal sepsis. Chest 2002, 121:292-295. 25. Manco-Johnson MJ, Knapp-Clevenger R: Activated protein Cco- ncentrate reverse...

Ngày tải lên: 12/08/2014, 22:21

... surprising degree of statistical heterogeneity that remains between the Adminis- tration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) trial [3] and the Recombinant Human Activated ... Administration of Drotrecogin Alfa (Activated) in Early Stage Stage Sepsis; APACHE = Acute Physiology and Chronic Health Evaluation; DrotAA = drotrecogin alfa (activat...

Ngày tải lên: 13/08/2014, 03:20

... Steingrub JS, Garber GE, Helterbrand D, Ely EW, et al., for the Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group: Efficacy and safety of recombinant human ... Rea-Neto A, et al., for the Administration of Drotrecogin alfa (activated) in Early Stage Severe Sepsis (ADDRESS) Study Group: Drotrecogin alfa (acti- vated) for adults with seve...

Ngày tải lên: 13/08/2014, 03:20

... evaluating the use of DrotAA in lower-risk patients with severe sepsis, in children with severe sepsis, and in patients receiving low- dose heparin [3]. In the Administration of Drotrecogin Alfa ... Siegel JP: Assessing the use of activated protein C in the treatment of severe sepsis. N Engl J Med 2002, 347:1030-1034. 4. Baillie JK, Murray G: Drotrecogin alfa (act...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 13/08/2014, 03:20