Báo cáo khoa học: "Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase " doc

... http://ccforum.com/content/9/3/R211 R211 Vol 9 No 3 Research Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C Vladimir Kuklin 1 , Mikhail Kirov 1 , Mikhail ... mechanisms involved have not yet been settled [14]. Studies in vitro have shown that the binding of ET-1 to its receptor migh...

Ngày tải lên: 12/08/2014, 22:21

... domain protein which interacts with GC-C was identified in a yeast two hybrid screen [44]. This protein named Ôintestine and kidney-enriched PDZ protein (IKEPP) interacts with GC-C through one of ... then incubated overnight with 5 lgÆmL )1 GC-C:4D7, an antibody raised to the protein kinase- like domain of GC-C [32] or with GC-C:4D7 antibody preadsorbed with a fusion...

Ngày tải lên: 08/03/2014, 08:20

... the incidence of severe sepsis is steadily increasing, the total number of deaths continues to increase [1-3]. In the setting of severe sepsis, early multi-modal, goal-directed therapy including ... with sepsis-induced organ dys- function who meet criteria for its administration. However, delays in initiating treatment with DrotAA in Canada are com- mon – in a registry of...

Ngày tải lên: 13/08/2014, 16:20

... haemodynamic effects. This is in contrast to our findings in septic pigs, in which norepine- phrine was associated with an increase in the hepatic lactate influx with no concomitant increase in the hepatic ... balance with norepinephrine. Only one study evaluated the effects of increasing MAP from 65 to 85 mmHg using norepinephrine [22]. In this study, conducted in 1...

Ngày tải lên: 13/08/2014, 11:22

... regional distribution found in piglets is very similar to the distribution of lung overinflation reported in patients in the early stage of ARDS: in the supine position, Figure 1 Severity of lung infection ... distributed in non-dependent lung regions with persisting lung aeration. In ventilated-inoculated piglets, lung infection involved more than two thirds...

Ngày tải lên: 13/08/2014, 03:20

... active-site histidine of the C-domain is 16 A ˚ , making it within the reach of the missing Ppant arm (capable of reaching 20 A ˚ dis- tance at full linear extension). However, the distances to ... (achieved by binding of an inhibitor) affects the relative conformation of the in cis interacting PCP domain. It is conceivable that most of this change is coordinated through a...

Ngày tải lên: 29/03/2014, 08:20

... risk for contracting leptospirosis, the patient admitted to having be en in con- tact with rat urine with his bare hands at a construction site in NYC. Discussion Leptospirosis is a zoonosis of ... bilirubin of 2.6 mg/dL, alkaline phosphatase (ALP) of 143 U/L, aspartate amino- transferase (AST) of 201 U/L, alanine aminotransferase (ALT) of 246 U/L, and creatine kinase o...

Ngày tải lên: 11/08/2014, 02:22

... left lung is unreliable. The auscultation method can result in incorrect positioning in 38% of cases, with wrong main stem intubated in 20.8% and double-lumen tube above the carina in 38.7% of ... transplant for COPD include severity of underlying airway obstruction, peri-operative injury to the donor lung and size of donor lung [60]. Bronchopleural fistula Interco...

Ngày tải lên: 12/08/2014, 23:20

... disease, lung sliding can be abolished in the absence of pneumothorax. The diagnosis remains uncertain in patients with normal lung aeration whereas in patients with lung injury, the presence of vertical ... lung sliding and absence of lung sliding may coexist in lateral regions of the chest wall. In this boundary region, called the lung point’ (P), lung sl...

Ngày tải lên: 13/08/2014, 03:20

... the 43-amino acid chitin-binding peptide isolated from the rubber tree Hevea brasiliensis [12], and com- prise the single hevein domain subfamily in a large group of chitin-binding proteins [13–16] ... chitin- binding domain, which is responsible for binding the carbohydrate. In addition to hevein, the members of this family are lectins, chitinases, some wound-induced proteins and a...

Ngày tải lên: 07/03/2014, 02:20