Báo cáo y học: "Erythropoietin and renin as biological markers in critically ill patients" potx

... comparisons,respectively. Renin measurement Renin was measured on the basis of its action on angiotensin in plasma, generating angiotensin I. Renin concentrationswere determined by radioimmunoassay (SANOFI Pasteur,Paris, ... an increased renin level in all patients and a significant relationship between EPO and plasma renin. Plasma renin progressively decreased in survivors, but itremained significantly elevated in ... response to infection leadingto numerous reactions in the host, including release of proin-flammatory and anti-inflammatory cytokines [1]. During sepsis,the endocrine, immune and nervous systems...

Báo cáo y học: "Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey" ppt

... and minimizethe dissemination of nondiscriminating and unnecessarytests. Pressing investigations in this field include accurate riskprofiling for both VTE and bleeding events in critically ill ... setting to critically ill patients may be further compromised by activation of thecoagulation and inflammatory cascades in many critically ill patients for myriad reasons [25,26].We hypothesize that ... case-by-case basis (18/29, 62.1%), infrequently prompted bypreprinted orders (5/29, 17.2%) or institutional policies (6/29,20.7%), and rarely by a formal VTE prophylaxis practice guide-line...

Báo cáo y học: "Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies" doc

... ICU was found to be statistically significantlyincreased in patients with A. baumannii infection in three offive studies examining this outcome.The increase in mortality of patients with infection ... found in the most severely ill patients, it mainly influ-enced mortality in the less severely ill. Finally, Wisplinghoff and colleagues [24], reported results from the SCOPE (Surveil-lance and ... Gili-Miner M: Mortality and the increase in length of stay attributable to the acquisi-Key messages• There has been controversy over whether colonization and infection with A. baumannii increase...

Báo cáo y học: "Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review and meta-analysis" docx

... No Yes No NoGysin [29] No Yes Yes Yes NoPorter [34] Yes No Yes Yes NoRaine [35] Yes No Yes No YesHeikkinen [31] No No Yes No NoFreeman [27] Yes No Yes Yes NoMassick [40] Yes No Yes Yes ... concealmentBlinding Intention-to-treat analysisPredefined outcomes Baseline ImbalanceHazard [30] No No Yes Yes NoCrofts [26] No No Yes Yes NoFriedman [28] No No Yes Yes NoHoldgaard [32] Yes No Yes Yes ... that included critically ill adults and reported at leastone clinically relevant outcome were included. Data extractedincluded trial characteristics, measures of study validity, and clinically...

Báo cáo y học: "Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial" doc

... melatonin in theroutine care of critically ill patients, our findings need to beconfirmed by a larger, possibly multicentre, randomised con-trolled trial, ideally using polysomnography as a continuousmeasure ... (CYP1A2) activity and co-administra-tion of interacting drugs [39]. The acute inflammatory cascaderelated to sepsis may adversely affect cytochrome P450 reg-ulation, including CYP1A2 enzyme ... from the arterial line, immediatelycentrifuged, and stored at -20°C until assay. Plasma melatoninwas measured in duplicate using a melatonin direct radioim-munoassay (Immuno Biological Laboratories,...

Báo cáo y học: " Pushing the envelope to reduce sedation in critically ill patients" ppsx

... sedation in critically ill patients.  is approach of using analgesia alone and avoiding sedation, unless necessary, has been the standard of care in the author’s ICU in Denmark since 1999. ... with continuous sedation. Furthermore; the intervention group was associated with a shorter ICU stay by 9.7 days and hospital stay by 24 days than the control group. Agitated delirium was more ... patients baseline characteristics, shows a slightly increased severity of illness in the control group (based on SAPS II: 46 vs. 50) and SOFA score (7.5 vs. 9).  is may have biased results...

Báo cáo y học: " Mucociliary and long-term particle clearance in airways of patients with immotile cilia" doc

... being involved in ourstudy and healthy subjects. These conditions may changeunder acute airway infections, resulting in mucus hyperse-cretion, which is more likely in PCD patients. As has ... frequency and coordina-tion of ciliary beating and rheology of airway secretions).Traditionally it has been assumed that particles depositingon the ciliated airways are rapidly cleared by mucociliaryclearance ... viruses in the airways and may be one reason for increased frequency ofinfections in PCD patients.IntroductionMucociliary clearance (MCC) is an integral part of lungdefense mechanisms, enabling...

Báo cáo y học: "Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)" potx

... andrograpanin is both anti-inflammatory and anti-infective; 14-deoxy-14,15-dehydroandrographolide is anti-inflammatory; isoandrographolide, 3,19-isopropylideneandrographolide and 14-acetylandrographolide ... phase through induction ofcell-cycle inhibitory protein and decreased expression ofcyclin-dependent kinase [45-49]. Other compounds mayblock the cell cycle progression at G2/M phase [42].Andrographolide ... by CCl4 administrationrestored plasma lipid peroxidation, alanine transaminase(ALT) and aspartate transaminase (AST) [94].Andrographolide significantly induced the expressionof CYP1A1 and...

Báo cáo y học: "Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study" pot

... critical illness and associated with poor outcome. Glycaemic control using insulinmay decrease morbidity and mortality. Many questions remainabout the cause of critical illness hyperglycaemia ... studies may employ other meth-ods to more directly assess insulin resistance in patients, such as hyperinsulinaemic euglycaemic clamping techniques,homeostasis model assessment-estimated insulin resistanceor ... differences and elucidating thepathogenesis of CIH may assist in developing individualisedglycaemic goals and treatment strategies in children with life-threatening illness or injury.Competing interestsThe...

Báo cáo y học: "Continuous noninvasive monitoring of barbiturate coma in critically ill children using the Bispectral™ index monitor" doc

... relativelyeasy to use, and nurses and physicians can easily be taughthow to interpret recordings. SR-BIS and recorded EEG tracesare continuously displayed, thus enabling continuous monitor-ing ... are required, combining pharma-cokinetic and pharmacodynamic studies with continuous EEG and BIS monitoring.Competing interestsThe authors declare that they have no competing interests.Authors' ... 5ResearchContinuous noninvasive monitoring of barbiturate coma in critically ill children using the Bispectral™ index monitorSandra A Prins1, Matthijs de Hoog2, Joleen H Blok3, Dick Tibboel1 and...

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