and overall survival in critically ill patients

... and during the initial clinical course in a large cohort of critically ill patients in a medical ICU In fact, critically ill patients with low endogenous suPAR levels upon admission, on Day and ... Comparing suPAR with single, routinely used clinical biomarkers of organ dysfunction and inflammation, suPAR displayed better predictive accuracy for both ICU and overall survival in critically ill ... sepsis In a prior study on patients with SIRS and suspicion of having communityacquired infections in a non-intensive care setting suPAR was found to have a low accuracy in diagnosing bacterial infection...

Ngày tải lên: 14/08/2014, 07:21

... severe enough, in the opinion of the treating intensivist, to warrant the initiation of RRT This definition was selected because the initiation of RRT in critically ill patients has clinical relevance ... in 68 (28%), hyperkalemia in 59 (25%), and toxins in (2%) The modality of renal replacement in the ICU was exclusively CRRT in 147, exclusively IHD in 48, and some combination of regimens using ... contribution for physicians, patients, and their families and has the potential to greatly impact the care of critically ill patients by aiding in and providing well-informed overall management decisions...

Ngày tải lên: 12/08/2014, 23:20

... Whereas colistin is mainly administered i.v in critically ill patients, it can be safely be administered by inhalation in patients with pneumonia/VAP or intrathecally in patients with meningitis due ... topical administration of colistin is noted in approximately 15% of patients Colistin’s clinical efficacy in critically ill patients In a recently published study, 258 adult critically ill patients ... considered in critically ill patients [13] CMS and colistin PKs have been recently examined in 18 adult critically ill patients who received i.v colistin for infections caused by MDR-GNB CMS was administered...

Ngày tải lên: 21/06/2014, 01:20

... (urinary tract) In contrast, only 17 (45%) cases showed complete agreement between clinical diagnoses and postmortem findings The remaining six patients (16%) had only minor additional findings ... The finding of undiagnosed carcinoma and pulmonary embolism is consistent with previous studies emphasizing the importance of maintaining a high index of suspicion for these diagnoses in the critically ... unexpected findings, leading to a falsely high incidence of missed diagnoses However, there is evidence that clinical diagnostic certainty does not predict postmortem findings, indicating that the incidence...

Ngày tải lên: 12/08/2014, 19:22

... mortality rate in critically ill patients with SLE is high We posit that gastrointestinal bleeding, intracranial haemorrhage and septic shock are significant prognostic factors in SLE patients admitted ... not be tested in the present study Key messages • The mortality rate in critically ill SLE patients remains high • We found that gastrointestinal bleeding, intracranial haemorrhage and septic shock ... 10 out of 258 patients with SLE in a previous study [22] Nevertheless, the actual frequency of and factors contributing to intracranial haemorrhage in SLE patients remain undefined In the ICU it...

Ngày tải lên: 12/08/2014, 22:21

... iron and erythropoietin, and weekly hemoglobin indices to day 21 Patients admitted with pre-existing diagnoses of hypothyroidism (13 patients) or vitamin B12 deficiency (four patients) were continued ... Hemoglobin (g/dl) aExcludes 25 patients with active bleeding bBMI unavailable for three bleeding patients and 12 nonbleeding patients (five nontransfused patients and seven transfused patients) ... of recombinant human erythropoietin in the critically ill patient: a randomized, doubleblind, placebo-controlled trial Crit Care Med 1999, 27:2346-2350 Corwin HL, Gettinger A, Pearl R, Fink MP,...

Ngày tải lên: 13/08/2014, 03:20

... baseline ± days baseline ± days Change in mitochondrial DNA (mtDNA)/nuclear DNA (nDNA) ratio between baseline and day (± 1) in the intensive care unit Of the 28 critically ill between baseline and ... critical illness outcome observed here Conclusion In critically ill patients requiring ventilation and with clinical evidence of hypotension, we observed low blood mtDNA levels at baseline Patients ... Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients N Engl J Med 2001, 345:1359-1367 Vanhorebeek I,...

Ngày tải lên: 13/08/2014, 08:20

... gastric scintigraphy, using both solid and liquid meals, in healthy subjects and non -critically ill patients [34-39] In critically ill patients, the breath test has a sensitivity of 71% and a specificity ... load in critically ill patients, particularly those with impaired motility [28,29], is also illustrated in the present study by the finding that the overall increase in plasma CCK and PYY in patients ... therapy within 24 hours prior to the study; and a history of diabetes mellitus All patients were receiving an insulin infusion according to a standard protocol, which was designed to maintain the...

Ngày tải lên: 13/08/2014, 08:21

... angiopoietin-1 and angiopoietin-2 concentrations in serum and plasma (a) Angiopoietin-1 (Ang-1) and (b) angiopoietin-2 (Ang-2) concentrations were determined in parallel in serum and in ethylenediamine ... and P = 0.7) in critically ill patients A subgroup analysis in SOFA score and gender-matched critically ill control patients was performed to compare Ang-1 and Ang-2 concentrations in patients with/without ... severity of illness in critically ill patients Scatter plots showing in 94 critically ill patients the correlation between Sequential Organ Failure Assessment (SOFA) scores and (a) circulating angiopoietin-1...

Ngày tải lên: 13/08/2014, 11:22

... Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients N Engl J Med 2001, 345:1359-1367 ... in patients treated with IIT [12] These data raise several interesting questions Does acute hyperglycemia alter neurons and skeletal muscle in such a way as to produce sustained weakness in patients ... acute hyperglycemia induces metabolic memory in neurons and/ or in skeletal muscle and produces the prolonged weakness we see in our patients? It is conceivable that hyperglycemia-induced mitochondrial...

Ngày tải lên: 13/08/2014, 15:21

... Dialysis Outcome Trial (HANDOUT), a single-center randomized controlled trial comparing standard and intensified extended dialysis therapy in patients with AKI at seven intensive care units (ICUs) ... 28), points (n = 45)) (b and d) Scatter plot showing the correlation of serum NGAL concentrations with (c) C reactive protein (CRP) levels, and (d) serum cystatin C levels in critically ill patients ... severity of systemic inflammation In line with this interpretation, increased NGAL concentrations have been found in the blood of patients with acute bacterial infections and during experimental...

Ngày tải lên: 13/08/2014, 20:21

... identifies critically ill patients at higher risk of death Implications for clinicians These findings expand our understanding of lactate as a clinical biomarker in the ICU Relatively small changes in ... 2009, 33:166-170 Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J: A comparison of epinephrine and norepinephrine in critically ill patients Intensive Care Med 2008 Chang ... prospectively in a large number of consecutive critically ill patients in four ICUs The data are numerical in nature and were measured independently; thus they were not amenable to selection bias or unintended...

Ngày tải lên: 13/08/2014, 20:21

... clinical psychologists and a trained and supervised staff of intensivists and nurses, whose purpose is to provide emotional support and coping strategies to conscious patients with critical illness ... members (starting during the phase when the patient is still unconscious) by promoting family-centred decision-making and supporting next of kin to choose appropriate interactions during their bedside ... medications and timing of return to previous employment at 12 months During the ICU stay, sedation was induced using propofol, fentanyl and/ or midazolam infusions, depending on the patient’s clinical...

Ngày tải lên: 14/08/2014, 07:21

Ngày tải lên: 14/08/2014, 08:21

... criteria Injury is defined as: increase in serum creatinine to >200 to 300% of baseline or urine output 12 h RIFLE criteria Failure is defined as: increase in serum creatinine to ... randomized studies are difficult and time consuming to conduct but they are still the gold standard for proving or rejecting new knowledge A not a priori defined finding from a prospective single ... Kidney Injury Network (AKIN) [8] The RIFLE classification was defined as follows: RIFLE criteria Risk is defined as: increase in serum creatinine of ≥26.4 μmol/l (150 to 200% of baseline) or urine...

Ngày tải lên: 14/08/2014, 08:21

... hyperglycemia, and insulin resistance in critically ill patients and its potential use as a biomarker in ICU patients Materials and methods Study design and patient characteristics We studied 170 patients ... correlated to hyperinsulinemia, hyperglycemia, and insulin resistance in several studies [14,26,27] In contrast, other studies could not verify these findings in insulin-resistant patients or those ... human glucose metabolism and insulin resistin, unlike the findings in murine models, is still unclear In our cohort as well as in a prior study of septic patients [9], resistin did not correlate...

Ngày tải lên: 13/08/2014, 16:21

... calcineurin inhibitor, hyperbilirubinemia, and hypoalbuminemia The incidence of kidney injury increased with an increase in the number of risk factors Hypoalbuminemia also was identified as an independent ... pathogen) and pneumonia (compared with bacteremia and abdominal infection), whereas age and proportional increase in creatinine independently predicted unfavorable infection outcome Lower mean colistin ... Increased creatinine level × 1.5 or GFR decrease >25% Injury (I) Increased creatinine level × or GFR decrease >50% Failure (F) Increased creatinine level × 3, GFR decrease >75% or creatinine level...

Ngày tải lên: 21/06/2014, 03:20

... seriously and critically ill patients, which indicated a significantly lower rate of pneumonia and atelectasis in patients receiving continuous postural oscillation [9] A less expensive and adaptable ... difference in pneumonia between trauma patients fed Immun-Aid (containing glutamine, arginine, omega-3-polyunsaturated fatty acids, nucleotides, and branched chain aminoacids) vs Vivonex (standard ... those 19 patients receiving prepyloric gastric feeds and no cases were observed in the 19 patients receiving post-pyloric feeds through a jejunal tube To avoid continuous alkalinization and intragastric...

Ngày tải lên: 12/08/2014, 18:20

... particularly in pulmonary medicine [31] and VTE [32], could better inform clinical decisions and minimize the dissemination of nondiscriminating and unnecessary tests Pressing investigations in this ... conducting integrated research programs [43] Canadian intensivists appear interested in addressing the many unanswered questions regarding VTE prevention and diagnosis in critically ill patients ... heparin in this population This is not the case for trauma patients; in one landmark trial, Geerts et al identified DVT in 31% of patients randomized to receive enoxaparin compared with 44% in patients...

Ngày tải lên: 12/08/2014, 18:21