Báo cáo khoa học: "A novel and stable "two-hit" acute lung injury model induced by oleic acid in piglets" doc

... purposes) Acta Veterinaria Scandinavica Open Access Research A novel and stable "two-hit" acute lung injury model induced by oleic acid in piglets Xiaofeng Li 1 , Yinglong Liu* 1 , Qiang ... pulmonary injury, and acute lung injury (ALI) often results in a high mortality and financial cost in pediatric patients. Evidence has showed that oleic...

Ngày tải lên: 12/08/2014, 18:22

... result in increased inspiratory and expiratory muscle activity [24], and is normally resolved clinically by either adapting ventilator settings, increasing sedation levels, or both [25]. Matching the ... ventilation are to decrease the oxygen costs of breathing and to improve gas exchange while minimizing iatrogenic lung injury – so- called ventilator -induced lung injury (...

Ngày tải lên: 12/08/2014, 23:21

... likewise induced by Occ WT but not by Occ DE9 (Fig. 4D). These data implied that Occ WT induced mitochondrial apoptosis [25], and that exon 9 played a major role in occludin- induced apoptosis. In ... In Chang cells, stained occludin was observed in the cytoplasmic region. Additionally, in Occ WT -overexpressing Hep3B and Huh7 cells, regions stained with antibody to he...

Ngày tải lên: 18/02/2014, 18:20

... third intracellular loop and the C-terminus, sug- gesting that phosphorylation is involved in the modula- tion of G protein coupling and receptor function [22]. The Asp110 and Asn337 in TM2 and ... in the salivary gland of octopuses (oct-TKs and eledoisin) and female mosquitoes (sialokinins), and not in other mollusks or insects that possess TKRPs [6,8]. Moreover, we cou...

Ngày tải lên: 19/02/2014, 00:20

... R-Smad proteins results in long-term actin polymerization, we investigated the involvement of Smad2 and Smad3 in TGFb1 -induced a-SMA gene regulation and protein incorporation into the actin network ... inhibitor of transcription actinomycin D, and changes in the actin cytoskeleton were monitored by fluorescence using rhodamine phalloidin staining. As shown in Fig. 1A, TGFb ca...

Ngày tải lên: 16/03/2014, 06:20

... studies have revealed that mutant huntingtin aggregates inter- act with several transcription factors, such as CREB- binding protein, TATA-binding protein, and NF-Y, resulting in reduced expression of their ... procedures Cell culture and transfection N2a and HeLa cells were routinely maintained in Ham’s F12 medium containing 10% fetal bovine serum. The human breast cancer T47D cell...

Ngày tải lên: 23/03/2014, 04:20

... 315.3 at retention tim e 8.1 and 15.6 min. The first p eak had m/z, retention time and UV spectra (inset 3 in D) corresponding to the 7-DHP standard (inset 2 in D and inset in C). The product was at ... 385.3 and UV spectra are shown in the inset in (B) and in inset 1 in (D). Ó FEBS 2004 P450scc in the skin (Eur. J. Biochem. 271) 4185 addition to the correct transcrip...

Ngày tải lên: 23/03/2014, 13:20

... a novel topology model that is well supported by both prediction methods and experimental results. We propose a novel nine- TM topology model with the C-terminus in the extracytosolic space and ... located in TM regions six and seven (D257 and D385 in PS1, indicated with ‘D’). This topology is also predicted by HMMTOP2.1 without using constrained prediction. (B) Pres...

Ngày tải lên: 23/03/2014, 13:20

... seed-storage proteins are composed of the two major globulins glycinin and b-conglycinin. They are folded and assembled into trimers in the ER, and then trans- ported and deposited in the protein storage ... results indicate that GmPDIM is an ER luminal protein. Association of GmPDIM with proglycinin and b-conglycinin a’ in the cotyledon GmPDIM has oxidative folding activity...

Ngày tải lên: 30/03/2014, 04:20

... highly expressed in rodent liver prompted investi- gation into whether this subunit may be regulated in vivo in liver by streptozotocin -induced diabetes and changes in insulin levels. Figure ... animals Diabetes was induced with either intravenous or intraperi- toneal injection of streptozotocin into male Wistar rats and insulin was subsequently administered intravenously in...

Ngày tải lên: 30/03/2014, 16:20