Báo cáo y học: "Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction" ppt

... to day 3 in the spleen. Increases of the corresponding proteins were significant in comparison with day 0 only in the case of IL-2 (day 6). By day 6 (transition to the chronic phase), the mRNA ... for any cytokine in any organ at any time point. Discussion The present study documents that, in AIA, elevation of IL- 1β in the SM as well as elevations of IL-...

Ngày tải lên: 09/08/2014, 06:22

... effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1α by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of osteoarthritis in murine knee joints. Methods 2-Methoxyestradiol ... IL-6. Conclusions Induction of osteoarthritis by 2-methoxyestradiol demonstrates the importance of HIF-1 in maintaining the integrity of hypoxic articular...

Ngày tải lên: 09/08/2014, 13:22

... in identical twins. J Bone Joint Surg Br 1 959 , 41:314-318. 11. Mabuchi A, Nakamura S, Takatori Y, Ikegawa S: Familial osteoar- thritis of the hip joint associated with acetabular dysplasia maps to ... Nishida K, Furuichi T, Toki H, Nishimura G, Kawabata H, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S: A novel dom...

Ngày tải lên: 09/08/2014, 13:22

... 18:11 http://www.jbiomedsci.com/content/18/1/11 Page 6 of 10 low taurine concentrations ≤ 10 -7 M. Therefore, the neuronal pathway involved in acid secretion induced by low taurine concentrations may predominantly involve in ... presence of taurine- containing c ells and taurine- induced acid secretion in the stomach. In the body of the stomach, taurine-...

Ngày tải lên: 10/08/2014, 05:21

... subsequent myocardial injury, in which apoptosis may play a key role in myocardial IR injury [2]. It is therefore important to find the end ogenous protective mechanism against apop- tosis induced by myocardial ... miR-13 3a, and decrease apoptosis of cardiomyocyte. Myocardial- specific miR-1 and miR-13 3a may play an important role in IPost protection by regulating...

Ngày tải lên: 10/08/2014, 05:21

... bleomycin 6 in bleomycin6 in bleomycin 6 in bleomycin- -induced lung induced lung induced lung induced lung inflammatory changes in mice inflammatory changes in miceinflammatory changes in mice inflammatory ... bleomycin bleomycinbleomycin bleomycin- -induced pulmonary inflammation in the rat induced pulmonary inflammation in the ratinduced pulmonary i...

Ngày tải lên: 12/08/2014, 14:20

... pro-inflammatory agents. Inflammation of the airways and lung parenchyma plays a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and increased tachykinin levels are ... [11]. The tachykinins, substance P and neurokinin A, are present in sensory afferent nerves and inflammatory cells in the airways. They may be released by a variety...

Ngày tải lên: 12/08/2014, 14:20

... that LPA regulates airway inflammation via stimulating the release of cytokines and inflammatory mediators that modulate infiltration of neutrophils and eosinophils into the airway, others point ... structural changes of the airway in asthma by recruiting, activating and promoting inflam- matory cells into the airway [38-40]. In addition to cytokines, lipid mediator...

Ngày tải lên: 12/08/2014, 14:20

... sensitization of murine bronchial smooth muscleFigure 2 Acetylcholine (ACh)-induced Ca 2+ sensitization of murine bronchial smooth muscle. (A) A typical recording of contraction induced by ... to understand changes in the contractile signaling of airway smooth muscle cells associated with the disease. Smooth muscle contraction including airways is mainly regula...

Ngày tải lên: 12/08/2014, 18:21

... factor- induced contraction are still unknown. In this study we investigated the role of contractile prostaglandins and Rho-kinase in growth factor-induced ASM contraction. Methods: Growth factor-induced ... subsequent activation of Rho-kinase. Therefore, we investigated the effects of inhibition of Rho-kinase, MEK and cyclooxyge- nase (COX) on growth factor...

Ngày tải lên: 12/08/2014, 18:22

... pathogen- esis of HIV/ AIDS. Significance of indirect cell killing for HIV vaccine/ therapeutics design Knowing the role for uninfected bystander cell killing in disease has not resolved the challenge of ... sparing the fraction of infected cells. Such a process will tend to increase the pro- portion of infected cells and diminish the proportion of uninfected cell...

Ngày tải lên: 12/08/2014, 23:22

... Central Page 1 of 11 (page number not for citation purposes) Retrovirology Open Access Research Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic ... containing syncytia in response to focal areas of virus infected cells. Plates were fixed and stained 3 days later and examined for plaques of s...

Ngày tải lên: 13/08/2014, 06:20

... and intron-exon Association of human TRIM5α haplotypes with HIV-1 disease progression in vivoFigure 3 Association of human TRIM5α haplotypes with HIV-1 disease progression in vivo. Panel A, Inferred ... (Gibco-Invitro- Restriction of HIV-1 by common human TRIM5α variantsFigure 2 Restriction of HIV-1 by common human TRIM5α var- iants. HeLa cells were...

Ngày tải lên: 13/08/2014, 09:20

... ST each) without significant differences among groups. Laboratory variables of organ function and arginine vasopressin plasma levels Alanine aminotransferas e and aspartate aminotransferase activity ... placebo; c P < 0.05 versus baseline; n = 7 each. ALT, alanine aminotransferase; AST, aspartate aminotransferase; AVP, arginine vasopressin. Figure 3 Arterial base excess (a) and arterial...

Ngày tải lên: 13/08/2014, 21:21

... Treatment of Cancer/National Institute of Allergy and Infectious Diseases Mycoses Study Group; IBPA, invasive bronchial- pulmonary aspergillosis; IPA, invasive pulmonary aspergillosis. Competing interests The ... Central Ltd Diagnosis of invasive bronchial-pulmonary aspergillosis in patients with chronic obstructive respiratory diseases Pierre Bulpa* and Alai...

Ngày tải lên: 14/08/2014, 08:21