Báo cáo y học: "Molecular mechanisms of severe acute respiratory syndrome (SARS)" pot

... immunodeficiency rather than autoimmune syndromes [40], although a recent linkage analysis study of 44 single nucleotide polymorphisms in 13 genes from the type I IFN pathway identified two poly- morphisms ... expression of type I IFNs, a major component of antiviral immunity [44]. TLR9 signalling through MyD88 by plasmacytoid dendritic cells can also produce high amounts of type I IF...

Ngày tải lên: 09/08/2014, 07:20

... and, finally, therapy of the syndrome. Abbreviations SOS, Sinusoidal obstr uction syndrome; HLA, human leukocyte antigen; VOD, veno-occlusive disease; CsA, cyclosporine A; MOF, multiple organ ... demonstrated very clearly in our patient. She improved completely, even after renal, cerebral and respiratory failure. Introduction We report a case of sinusoidal obstruction syndrome (SOS...

Ngày tải lên: 11/08/2014, 17:21

... Assistant Professor of Medicine and Staff Physician at the Department of Gastroenterology and Hepatology, University Hospital Freiburg, Germany. Since 2004 he is the head of the Division of Gastroenterology ... discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mec...

Ngày tải lên: 02/11/2012, 10:00

... functional studies of the carboxyl-terminal domain Yoko Kobayashi, Toshiaki Nakajima and Ituro Inoue Division of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, Tokyo, Japan Lipoprotein ... endothelial lipase [1,2]. The primary function of LPL is triglyceride hydrolysis in triglyceride-rich lipoproteins, such as chylomicron and very low density lipoprotein...

Ngày tải lên: 21/02/2014, 15:20

... regulation of IRF-4 activity by the immunophilin FKBP52. Immunity 12, 129–140. 80 Shen ZJ, Esnault S & Malter JS (2005) The peptidyl– prolyl isomerase Pin1 regulates the stability of granulo- cyte–macrophage ... determined by X-ray crys- tallography [34]. In this structure of the peptide–CDC4 complex, however, Pin1 is missing, whereas in the study on cyclin E degradation, Pin1 was b...

Ngày tải lên: 07/03/2014, 05:20

... Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada; 2 Laboratory of Gynecologic Oncology, Department of Obstetric Gynecology and Reproductive Biology, ... USA; 3 Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; 4 Department of Immunology, University of Toronto, Toronto, Ontario, Canada SHP-1, a pro...

Ngày tải lên: 08/03/2014, 23:20

... cells displayed a typical pattern of neutral trehalase activity, with low level of enzyme activity in unstressed cells that increases strongly upon stress. Notably, we were unable to detect in situ any ... regulated by phosphorylation of the enzyme protein at serine residues [8,9]. Comparatively much less is known about the regulation of the trehalose synthesis in the evolutionarily d...

Ngày tải lên: 08/03/2014, 23:20

... tetrahydrocolumbamine using this 80% pure tetrahydrocolumbamine. To quantify the enzymatic activity of CoOMT, the transfer of the 3 H-labeled methyl group of S-adenosyl- L - [methyl- 3 H]methionine (0.5 MBqÆlmol )1 )(PerkinElmer Life ... M.H. (1990) S-adenosyl- L -methionine: 3¢-hydroxy-N-methyl-(S) -coclaurine-4¢-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-ret...

Ngày tải lên: 17/03/2014, 10:20

... transcrip- tion by being an auxiliary member of the RNA polymerase II holoenzyme complex. This view is sup- ported by the observation that the function of MRG19 is reminiscent of Gal11p in many respects, ... toxic to wild-type yeast strains that constitutively express galactokinase, due to the accumula- tion of 2-deoxygalactose-1-phosphate [40]. Growth of a wild-type strain bearing...

Ngày tải lên: 31/03/2014, 08:20

... features of the T cell response. Recently, many new costimulatory pathways have been discovered that influence the properties of T cell responses. The discovery of novel costimulatory ligands/receptor ... cell regulatory molecules over the 20 years since the discovery of the TCR have shaped much of our understanding today regarding the immune system. After such a great amount of r...

Ngày tải lên: 09/08/2014, 01:24