... TseLY, Tsang T, Liu SH, Kong JH, Lau EM, Ferguson NM, Anderson RM:Epidemiological determinants of spread of causal agent of severeacuterespiratorysyndrome in Hong Kong. Lancet2003, 361:1761-1766.50. ... pzabel@fz-borstel.de* Corresponding author Severe AcuteRespiratory SyndromeSARScoronavirusmolecular mechanismstherapyvaccinationAbstract Severe acuterespiratorysyndrome (SARS) is a new infectious ... mutation innatural infections have been shown to contribute to thediversification of the coronaviruses. Because of the dem-onstrated ability of coronaviruses to recombinate, thequestion whether...
... accession number AY304495) on fetal rhesusmonkey kidney cell line FRhK-4 in the presence of high concentrations of this adamantine derivative. Thehalf maximal effective concentration of bananin on these ... Identification of novel small-molecule inhibitors of severeacuterespiratory syndrome- associated corona-virus by chemical genetics. Chem Biol 11, 1293–1299.25 Thompson JD, Higgins D & Gibson TJ ... cell culture system of SARS-CoV, bananin inhibited viral replication at ahalf maximal effective concentration of less than10 lm and a concentration causing 50% of cell death of over 300 lm, suggesting...
... determinants of spread of causal agent ofsevereacute respiratory syndrome in Hong Kong. Lancet, 2003. 361:1761-6. 68. Pan S.F., et al. Cardiac arrest in severeacuterespiratory syndrome: analysis of ... ventilation in the treatment of acuterespiratory failure in severeacuterespiratory syndrome. Chest (in press) 44. Liu X.Q., et al. Management of critical severeacuterespiratorysyndrome ... Development of a standard treatment protocol for severeacuterespiratory syndrome. Lancet, 2003. 361:1615-6. 12. Lee N., et al. A major outbreak ofsevereacuterespiratorysyndrome in Hong Kong....
... of RS motif phosphor-ylation on the biological function of the N protein, weFig. 3. The translation inhibition activity of the SARS-CoV N proteinis modulated by phosphorylation. Translation ... localization. Takentogether, phosphorylation of the severeacuterespiratory syndrome- CoVnucleocapsid protein modulates its activity in translation control and alsointerferes with its oligomerization ... motif of the severeacuterespiratorysyndrome coronavirusnucleocapsid protein modulates its multimerization,translation inhibitory activity and cellular localizationTsui-Yi Peng1,2, Kuan-Rong Lee2and...
... protein of the severeacute respiratory syndrome- coronavirus (SARS-CoV), resulting in high level of surface expression of the spikeprotein when it is expressed on its own in vitro.Presentation of ... the severeacuterespiratory syndrome- coronavirus.BackgroundThe recent severeacuterespiratorysyndrome (SARS) epi-demic, which affected over 30 countries, resulted in morethan 8000 cases of ... Chen PJ, National Taiwan University SARS Research Team:Characterization ofsevereacuterespiratory syndrome coronavirus genomes in Taiwan: molecular epidemiologyand genome evolution. Proc Natl...
... retention of the spike protein. This motif is missing from the spike protein of the severeacute respiratory syndrome- coronavirus (SARS-CoV), resulting in high level of surface expression of the ... confer certainadvantages during the replication of the severeacuterespiratory syndrome- coronavirus.BackgroundThe recent severeacuterespiratorysyndrome (SARS) epi-demic, which affected over ... spikeprotein when it is expressed on its own in vitro.Presentation of the hypothesis: It has been shown that the severeacuterespiratory syndrome- coronavirus genome contains open reading frames...
... negative. On day 4, concomi-tantly with an elevation of WBC from 400 to 10,400/àL(ANC = 4900/àL), respiratory conditions precipitated andendotracheal intubation and mechanical ventilation werestarted ... Heavyimmunosuppression consisting of the combined use of cyclophosphamide and high-dose steroids may be con-sidered [8, 9].Case presentationWe report the case of an 8-month-old Caucasian girlreferred ... associated with a high risk of developing severe infections. Recently, the use of monoclonal antibodies (rituximab) has allowed sustained remissions to beobtained in the majority of pediatric patients...
... treated for severe acute malnutrition will need 10–15 kg of RUTF, given over a period of six to eight weeks.Community-based management of severeacute malnutrition in the context of high HIV ... presentation ofsevereacute malnutrition and HIV infection and AIDS in children, especially in poor areas, strong links between community-based management ofsevereacute malnutrition and AIDS ... complications and implemented on a large scale, community-based management of severe acute malnutrition could prevent the deaths of hundreds of thousands of children.Nearly 20 million children...
... bethemajorsourceofRLSbecause bilateral inj ections of this interspace alone caninduce remission of RLS symptoms [9]. The possiblecontribution to neuropathic foot symptoms a nd sleepdysfunction of the ... 4:306http://www.jmedicalcasereports.com/content/4/1/306Page 4 of 6 CAS E REP O R T Open AccessRemission ofsevere restless legs syndrome andperiodic limb movements in sleep after bilateralexcision of multiple foot ... take full advantage of: ã Convenient online submissionã Thorough peer reviewã No space constraints or color gure chargesã Immediate publication on acceptanceã Inclusion in PubMed, CAS, Scopus...
... treatment of the former, almostlethal, severe SOS to date. To increase response totreatment, ongoing investigations focus on the combina-tion of defibritode with other drugs as the inhibitor of glutathione ... likely based on MOF withconsecutive coagulopathy.The reason for the VOD in our case is hard to trace. Theinitial risk profile of our patient was low. However,persistent fever and concordant ... as the inhibitor of glutathione depletion n-acetyl cysteine. In general, man-agementofSOSshouldbebasedonprophylaxis:identif ication of patients at risk, avoidance of SOS-inducing therapies,...
... structure of the dissertation includes: 2 pages of Introduction, 35 pages of Literature review, 26 pages of Methodology, 31 pages of Findings, 28 pages of Discussion,2 pages of Conclusion, 1 page of ... developing countries and 4 million of them died because of ARI. Therefore, WHOconsiders the identification and prevention of the origin of ARI as one of their foundationalstratergies in order to ... an24 MINISTRY OF EDUCATION AND TRAINING MINISTRY OF HEALTHNATIONAL INTITUTE OF HYGIENE AND EPIDEMIOLOGYVŨ VĂN THÀNHRESEARCH ON THE CAUSES OFACUTE RESPIRATORY INFECTIONS AMONG CHILDREN UNDER...