Báo cáo y học: "A mechanism of airway injury in an epithelial model of mucociliary clearance" doc

... 3). Discussion The important findings of this study are: 1. the develop- ment of a model of airway epithelial injury that can be used for study of ultra-structural and molecular events in airway injury that are ... activated in the tissue is another important question. An understand- ing of this injury mechanism may lead to ways to inter- vene in the early st...

Ngày tải lên: 12/08/2014, 18:21

... changes in cell stiffness using magnetic twisting cytometry (MTC) and changes in cell traction force using Fourier transform traction micro- scopy (FTTM). Finally, scaling up to the level of an intact ... (Grand Island,NY).Thesyntheticarginine-glycine-aspartic acid (RGD) containing peptide was purchased from American Peptide Company (Sunnyvale,CA).Primaryantibodies against HSP20, cofi...

Ngày tải lên: 12/08/2014, 13:22

... the mean of at least three independent determinations. Cysteine and tryptophan were not determined. Hydroxyproline, hydroxylysine and phosphoserine were not detected in all samples. Amino acid Water-soluble matrix Water-insoluble matrix EDTA-soluble matrix EDTA-insoluble matrix Asx ... Nevertheless, they were aspartic-rich in EDTA-SM whilst being quite glutamic acid- rich in WSM. Glyc...

Ngày tải lên: 21/02/2014, 01:21

... convert the proposed intermediate (4-hydroxy- 3-methoxyphenyl-b-hydroxypropionyl-CoA) into vanillin [28]. An other well known example is trans-o-hydroxy- benzylidenepyruvate hydratase/aldolase [29,30] ... best of our knowledge, the induction of an enzymatic activity in nongerminating spores has so far only been described in spores of Aspergillus oryzae,i.e.a-amylase, invertase a...

Ngày tải lên: 21/02/2014, 01:21

... specifically interact with the tyrosine motifs pY401 and pY429pY431. pY429pY431 was more potently recruiting SOCS-3 than pY401, reflecting the high affinity binding determined by SPR. The nonphosphorylated ... phosphotyrosines bind to the phosphotyrosine binding pocket of the SH2 domain, with R94 only playing a minor role in the binding of these peptides. DISCUSSION The cytoplasmic part o...

Ngày tải lên: 24/03/2014, 00:21

... For analysis, matrix solutions consisting of sinapinic acid, 3,5-dimethoxy-4-hydroxycinnaminic acid, or a-cyano-4-hydroxycinnamic acid, were mixed in a 1 : 1 ratiowithsamples,spottedonthetargetandallowedto dry. MASSLYNX (Micromass ... previ- ously for birtoxin [6]. Brie y, the cysteine residues of the peptide were reduced and carboxymethylated by incubating in 6 M guanidine hydrochlor...

Ngày tải lên: 31/03/2014, 08:20

... proinflammatory cytokines TNF-α and IL-6 was increased. These findings suggest that impairment of immune tolerance by increased T- cell reactivity does not lead to enhanced susceptibility to CIA and point ... disease by destroying target tissues through induction of apoptosis of chondrocytes [33]. Alternatively, Fas could contribute to synovial hyperplasia by inducing proliferation of...

Ngày tải lên: 09/08/2014, 01:23

... Overexpres- sion of a number of HSA21 genes, including Dyrk1a, Synj1 and Sim2, results in learning and memory defects in mouse models, suggesting that trisomy of these genes may contribute to learning disability ... genes, which can be overexpressed in an inducible manner. Each clone was transcriptionally profiled in inducing versus non- inducing conditions. Analysis of the...

Ngày tải lên: 09/08/2014, 20:22

... human metap- neumovirus, PIV, human rhinovirus and human corona- virus play an important role in the etiology of community-acquired pneumonia in adults [33]. The increasingly widespread use of ... nasopharyngeal and tracheal samples were negative for influenza A and B (including H1N1), respiratory syn- cytial virus (RSV) types A and B and parainfluenza virus (PIV) types 1 thr ough 4...

Ngày tải lên: 10/08/2014, 23:21

... amphotericin B in the presence of 60 ng/mL recombinant human granulocyte macrophage colony stimulating factor (GM-CSF) and 150 ng/mL recombinant human IL-4. Medium and cytokines were replaced every 2 days. ... 20:4169-4180. 22. Austin E, Robins R, Baldwin R, Durrant L: Induction of delayed hypersensitivity to human tumor cells with a human mono- clonal anti-idiotypic antibody. J Natl Ca...

Ngày tải lên: 11/08/2014, 10:23